Withdrawal of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Elicits Oxidative Stress and Induces Endothelial Dysfunction in Mice

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

1994 • 8,631 citations

Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia

1995 • 7,378 citations

Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol Levels

1998 • 5,229 citations

Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease

1994 • 1,697 citations

Current Perspectives on Statins

2000 • 1,220 citations

Beneficial Effects of Cholesterol-Lowering Therapy on the Coronary Endothelium in Patients with Coronary Artery Disease

1996 • 1,066 citations

Simvastatin, an HMG–Coenzyme A Reductase Inhibitor, Improves Endothelial Function Within 1 Month

1997 • 968 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

The Neutrophil NADPH Oxidase

2002 • 904 citations

A gp91phox Containing NADPH Oxidase Selectively Expressed in Endothelial Cells Is a Major Source of Oxygen Radical Generation in the Arterial Wall

2000 • 596 citations

Improvement of Nitric Oxide–Dependent Vasodilatation by HMG-CoA Reductase Inhibitors Through Attenuation of Endothelial Superoxide Anion Formation

2000 • 520 citations

Withdrawal of Statins Increases Event Rates in Patients With Acute Coronary Syndromes

2002 • 473 citations

Manganese superoxide dismutase in disease

2001 • 373 citations

Inhibition of Geranylgeranylation Reduces Angiotensin II-Mediated Free Radical Production in Vascular Smooth Muscle Cells: Involvement of Angiotensin AT1 Receptor Expression and Rac1 GTPase

2001 • 350 citations

Role of NADPH Oxidase in the Vascular Hypertrophic and Oxidative Stress Response to Angiotensin II in Mice

2001 • 336 citations

Suppression of Endothelial Nitric Oxide Production After Withdrawal of Statin Treatment Is Mediated by Negative Feedback Regulation of Rho GTPase Gene Transcription

2000 • 272 citations

Cerivastatin, a Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor, Improves Endothelial Function in Elderly Diabetic Patients Within 3 Days

2001 • 258 citations

Vascular effects of HMG CoA-reductase inhibitors (statins) unrelated to cholesterol lowering: new concepts for cardiovascular disease

2001 • 254 citations

Induction of NAD(P)H Oxidase by Oxidized Low-Density Lipoprotein in Human Endothelial Cells

2001 • 254 citations

Rapid effects on vascular function after initiation and withdrawal of atorvastatin in healthy, normocholesterolemic men

2001 • 182 citations

A transferable, beta‐naphthoflavone‐inducible, hyperpolarizing factor is synthesized by native and cultured porcine coronary endothelial cells.

1996 • 174 citations

Protective roles of cytokines against radiation: Induction of mitochondrial MnSOD

1995 • 172 citations

Rho GTPases as Targets of Bacterial Protein Toxins

2000 • 167 citations

Direct Vascular Effects of HMG-CoA Reductase Inhibitors

2000 • 161 citations

Vascular endothelial growth factor induces manganese‐superoxide dismutase expression in endothelial cells by a Racl‐regulated NADPH oxidase‐dependent mechanism

2001 • 160 citations

Role of Increased Production of Superoxide Anions by NAD(P)H Oxidase and Xanthine Oxidase in Prolonged Endotoxemia

1999 • 125 citations

NADPH Oxidase Mediates Tissue Factor–Dependent Surface Procoagulant Activity by Thrombin in Human Vascular Smooth Muscle Cells

2002 • 115 citations

Function of wild-type or mutant Rac2 and Rap1a GTPases in differentiated HL60 cell NADPH oxidase activation

1995 • 109 citations

Regulation of Cell Function by Rho Family GTPases

2000 • 100 citations

Mechanism of NADPH Oxidase Activation by the Rac/Rho-GDI Complex

2001 • 92 citations

Nitrate tolerance, rebound, and their clinical relevance in stable angina pectoris, unstable angina, and heart failure

1997 • 80 citations

Statin therapy: where are we? where do we go next?

2001 • 38 citations

Prenylation and G Protein Signaling

1994 • 25 citations

Tolerance, rebound, and time-zero effect of nitrate therapy

1992 • 15 citations