Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol.

Two cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma membrane during cell activation.

1990 • 435 citations

Possible mechanisms of emphysema in smokers. In vitro suppression of serum elastase-inhibitory capacity by fresh cigarette smoke and its prevention by antioxidants.

1978 • 364 citations

The electron transport chain of the microbicidal oxidase of phagocytic cells and its involvement in the molecular pathology of chronic granulomatous disease.

1989 • 286 citations

Immunomodulating agents of plant origin. I: Preliminary screening

1986 • 284 citations

Metabolic activation of natural phenols into selective oxidative burst agonists by activated human neutrophils

1990 • 231 citations

The Human Neutrophil Respiratory Burst Oxidase

1990 • 225 citations

Evidence for reactive nitrogen intermediates in killing of staphylococci by human neutrophil cytoplasts. A new microbicidal pathway for polymorphonuclear leukocytes.

1992 • 186 citations

Two transduction sequences are necessary for neutrophil activation by receptor agonists.

1988 • 172 citations

Characterization of two monoclonal antibodies against cytochrome b558 of human neutrophils

1989 • 170 citations

The effect of the NADPH oxidase inhibitor diphenyleneiodonium on aerobic and anaerobic microbicidal activities of human neutrophils

1988 • 167 citations

Location of the protease-inhibitory region of secretory leukocyte protease inhibitor.

1990 • 165 citations

An Improved Method for the Isolation of Eosinophilic Granulocytes From Peripheral Blood of Normal Individuals

1988 • 151 citations

Ultrastructural localization of bronchial antileukoprotease in central and peripheral human airways by a gold-labeling technique using monoclonal antibodies.

1986 • 122 citations

Rapid deactivation of NADPH oxidase in neutrophils: continuous replacement by newly activated enzyme sustains the respiratory burst

1988 • 75 citations

Priming of the respiratory burst in human eosinophils is accompanied by changes in signal transduction.

1990 • 59 citations

Interactions among stimulated human polymorphonuclear leucocytes, released elastase and bronchial antileucoprotease

1988 • 58 citations

Proteinase inhibitory activities of antileukoprotease are represented by its second COOH-terminal domain

1990 • 49 citations

Different selectivities of oxidants during oxidation of methionine residues in the α‐1‐proteinase inhibitor

1989 • 46 citations

Localization of the luminol‐dependent chemiluminescence reaction in human granulocytes

1989 • 38 citations

Release of azurophilic granule contents in fMLP-stimulated neutrophils requires two activation signals, one of which is a rise in cytosolic free Ca2+

1991 • 31 citations

Priming of human eosinophils by platelet-activating factor enhances the number of cells able to bind and respond to opsonized particles.

1992 • 30 citations

The Imbalance between Granulocyte Neutral Proteases and Antiproteases in Bronchial Secretions from Patients with Cystic Fibrosis1

2015 • 28 citations

Recombinant Elastase Inhibitors for Therapy

1991 • 11 citations

The effects of N‐ethylmaleimide on extracellularly and intracellularly generated chemiluminescence in neutrophils indicate that the rate of deactivation of NADPH‐oxidase is higher when the oxidase system is localized on the plasma membrane than when it is localized on the phagosomal membrane

1991 • 10 citations