PI3‐kinase p85α Is a Target Molecule of Proline‐rich Antimicrobial Peptide to Suppress Proliferation of ras‐Transformed Cells

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Peptide Antibiotics and Their Role in Innate Immunity

1995 • 1,602 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Structural basis for the binding of proline-rich peptides to SH3 domains

1994 • 1,016 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt

1999 • 762 citations

The GTPase dynamin binds to and is activated by a subset of SH3 domains

1993 • 557 citations

Ras-Dependent Induction of Cellular Responses by Constitutively Active Phosphatidylinositol-3 Kinase

1995 • 553 citations

Rho Family GTPases Bind to Phosphoinositide Kinases

1995 • 469 citations

PR39, a peptide regulator of angiogenesis

2000 • 383 citations

Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds.

1994 • 364 citations

Amino acid sequence of PR‐39

1991 • 343 citations

In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002).

2000 • 301 citations

RAS pathways to cell cycle control and cell transformation

1998 • 247 citations

Interleukin-6 Inhibits Transforming Growth Factor-β-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Akt and Signal Transducers and Activators of Transcription 3 Pathways

1999 • 230 citations

Regulation of the cell cycle machinery by oncogenic ras.

1996 • 202 citations

Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes.

1995 • 195 citations

PR-39, a proline-rich antibacterial peptide that inhibits phagocyte NADPH oxidase activity by binding to Src homology 3 domains of p47 phox.

1996 • 188 citations

Inhibition of ubiquitin-proteasome pathway–mediated IκBα degradation by a naturally occurring antibacterial peptide

2000 • 155 citations

Reduced expression of syndecan‐1 in human hepatocellular carcinoma with high metastatic potential

1997 • 136 citations

Targeting signal transduction for disease therapy

1996 • 127 citations

Reduced expression of syndecan-1 in human hepatocellular carcinoma with high metastatic potential

1997 • 124 citations

PR-39, a Syndecan-inducing Antimicrobial Peptide, Binds and Affects p130Cas

1998 • 108 citations

A Sos‐derived peptidimer blocks the Ras signaling pathway by binding both Grb2 SH3 domains and displays antiproliferative activity

1999 • 87 citations

A cDNA Derived from Pig Bone Marrow Cells Predicts a Sequence Identical to the Intestinal Antibacterial Peptide PR-39

1993 • 84 citations

Specific Activation of p85-p110 Phosphatidylinositol 3′-Kinase Stimulates DNA Synthesis by ras- and p70 S6 Kinase-Dependent Pathways

1997 • 71 citations

Proline-rich antimicrobial peptide, PR-39 gene transduction altered invasive activity and actin structure in human hepatocellular carcinoma cells

1999 • 56 citations

Dominant transformation by mutated human ras genes in vitro requires more than 100 times higher expression than is observed in cancers

1997 • 51 citations

Selective cytotoxicity of farnesylamine to pancreatic carcinoma cells and Ki-ras–transformed fibroblasts

1998 • 29 citations

Increased connexin-43 and gap junctional communication correlate with altered phenotypic characteristics of cells overexpressing the receptor for hyaluronic acid-mediated motility.

1996 • 19 citations

Mitogen-activated protein kinase antisense oligonucleotide inhibits the growth of human lung cancer cells.

1999 • 14 citations