Cholinergic Changes in the APP23 Transgenic Mouse Model of Cerebral Amyloidosis

A new and rapid colorimetric determination of acetylcholinesterase activity

1961 • 25,114 citations

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

1983 • 3,028 citations

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

1991 • 2,982 citations

Some new, simple and efficient stereological methods and their use in pathological research and diagnosis

1988 • 2,948 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

A rapid radiochemical method for the determination of choline acetyltransferase

1975 • 2,406 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

Translating cell biology into therapeutic advances in Alzheimer's disease

1999 • 1,592 citations

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1997 • 1,438 citations

Amyloid, the presenilins and Alzheimer's disease

1997 • 1,370 citations

Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme

1996 • 1,058 citations

New stereological methods for counting neurons

1993 • 951 citations

Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

1992 • 899 citations

Alzheimer's Disease--Genotypes, Phenotype, and Treatments

1997 • 884 citations

Tau protein and the neurofibrillary pathology of Alzheimer's disease

1993 • 710 citations

Cholinergic function and intellectual decline in Alzheimer's disease

1986 • 605 citations

Microglial response to amyloid plaques in APPsw transgenic mice.

1998 • 580 citations

Neurochemical Correlates of Dementia Severity in Alzheimer's Disease: Relative Importance of the Cholinergic Deficits

1995 • 572 citations

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor.

1992 • 557 citations

Alzheimer's disease

1982 • 538 citations

Laying it on thick

1999 • 471 citations

Topographic analysis of the innervation of the rat neocortex and hippocampus by the basal forebrain cholinergic system

1983 • 461 citations

A modified histochemical technique to visualize acetylcholinesterase-containing axons.

1985 • 441 citations

Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.

1993 • 401 citations

Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid

1999 • 392 citations

Cortical projection patterns of the medial septum‐diagonal band complex

1990 • 387 citations

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease.

1996 • 373 citations

Animal models of Alzheimer's disease: experimental cholinergic denervation

1988 • 340 citations

Association of Microglia with Amyloid Plaques in Brains of APP23 Transgenic Mice

1999 • 332 citations

Essential role of neocortical acetylcholine in spatial memory

1995 • 310 citations

β-Amyloid_1–42Peptide Directly Modulates Nicotinic Receptors in the Rat Hippocampal Slice

2001 • 284 citations

Cell loss and shrinkage in the nucleus basalis Meynert complex in Alzheimer's disease

1990 • 278 citations

Spontaneous Hemorrhagic Stroke in a Mouse Model of Cerebral Amyloid Angiopathy

2001 • 274 citations

Comparative Analysis of Amyloid-β Chemical Structure and Amyloid Plaque Morphology of Transgenic Mouse and Alzheimer's Disease Brains

2001 • 250 citations

Cortical biopsy in Alzheimer's disease: Diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations

1992 • 225 citations

Prominent Cerebral Amyloid Angiopathy in Transgenic Mice Overexpressing the London Mutant of Human APP in Neurons

2000 • 220 citations

Hippocampal neuron and synaptophysin-positive bouton number in aging C57BL/6 mice

1998 • 218 citations

Neurochemical activities in human temporal lobe related to aging and Alzheimer-type changes

1981 • 211 citations

Amyloid-Associated Neuron Loss and Gliogenesis in the Neocortex of Amyloid Precursor Protein Transgenic Mice

2002 • 206 citations

Retrograde changes in cholinergic neurons in the basal forebrain of the rat following cortical damage

1983 • 197 citations

Reorganization of Cholinergic Terminals in the Cerebral Cortex and Hippocampus in Transgenic Mice Carrying Mutated Presenilin-1 and Amyloid Precursor Protein Transgenes

1999 • 196 citations

β-Amyloid peptides as direct cholinergic neuromodulators: a missing link?

1998 • 194 citations

Cerebral Amyloid Induces Aberrant Axonal Sprouting and Ectopic Terminal Formation in Amyloid Precursor Protein Transgenic Mice

1999 • 189 citations

Evolution of Alzheimer's disease-related cytoskeletal changes in the basal nucleus of Meynert

2000 • 186 citations

Progressive age-related impairment of cognitive behavior in APP23 transgenic mice

2002 • 180 citations

Colocalization of cholinesterases with ? amyloid protein in aged and Alzheimer's brains

1993 • 167 citations

Convergent cholinergic activities in aging and Alzheimer's disease

1992 • 156 citations

The Cholinergic Deficit Coincides with Aβ Deposition at the Earliest Histopathologic Stages of Alzheimer Disease

2000 • 145 citations

Pharmacological Drug Treatment of Alzheimer Disease: The Cholinergic Hypothesis Revisited

1998 • 142 citations

Amyloid beta-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain.

1996 • 131 citations

Improved electrophoretic separation and immunoblotting of beta‐amyloid (Aβ) peptides 1–40, 1–42, and 1–43

1997 • 131 citations

Cholinergic activity and amyloid precursor protein metabolism

1997 • 130 citations

CORRELATION OF CORTICAL CHOLINERGIC AND GABA DEFICITS WITH QUANTITATIVE NEUROPATHOLOGICAL FINDINGS IN SENILE DEMENTIA

1984 • 129 citations

An Immunological Study of Rat Acetylcholinesterase: Comparison with Acetylcholinesterases from Other Vertebrates

1984 • 121 citations

Chapter 28 The systems-level organization of cholinergic innervation in the human cerebral cortex and its alterations in Alzheimer's disease

1996 • 121 citations

Dose-dependent CSF acetylcholinesterase inhibition by SDZ ENA 713 in Alzheimer's disease

2009 • 120 citations

Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation

1999 • 111 citations

Cholinergic innervation of mouse forebrain structures

1994 • 107 citations

Decrease of neocortical choline acetyltransferase after lesion of the globus pallidus in the rat

1978 • 105 citations

Electrophoretic Separation of βA4 Peptides (1–40) and (1–42)

1996 • 99 citations

Relationship Between Plaques, Tangles, and Loss of Cortical Cholinergic Fibers in Alzheimer Disease

1998 • 97 citations

Expression of APP in transgenic mice: a Comparison of neuron-specific promoters

1996 • 94 citations

Neuropathology of Mice Carrying Mutant APPswe and/or PS1M146L Transgenes: Alterations in the p75NTR Cholinergic Basal Forebrain Septohippocampal Pathway

2001 • 89 citations

Acetylcholinesterase-Positive Fiber Deafferentation and Cell Shrinkage in the Septohippocampal Pathway of Aged Amyloid Precursor Protein London Mutant Transgenic Mice

2000 • 87 citations

Brain Trauma in Aged Transgenic Mice Induces Regression of Established Aβ Deposits

2000 • 87 citations

Cholinergic activation of phosphoinositide signaling is impaired in Alzheimer's disease brain

1997 • 81 citations

Effect of alkalizing agents on the processing of the β-amyloid precursor protein

1996 • 76 citations

Survival and plasticity of basal forebrain cholinergic systems in mice transgenic for presenilin-1 and amyloid precursor protein mutant genes

2001 • 72 citations

Cholinergic deafferentation of the rabbit cortex: a new animal model of Aβ deposition

2000 • 64 citations

In Vivo Regulation of Amyloid Precursor Protein Secretion in Rat Neocortex by Cholinergic Activity

1997 • 63 citations

An unbiased method for estimation of total epidermal nerve fibre length

1996 • 61 citations

Neurofibrillary degeneration and cell loss in the nucleus basalis in comparison to cortical Alzheimer pathology

1998 • 57 citations

A Brain Regional Analysis of Morphologic and Cholinergic Abnormalities in Alzheimer's Disease

1989 • 56 citations

Estimating neuron dendritic length in 3D from total vertical projections and from vertical slices

1992 • 45 citations

Immunocytochemical distribution of peptidergic and cholinergic fibers in the human amygdala: their depletion in Alzheimer's disease and morphologic alteration in non-demented elderly with numerous senile plaques

1993 • 44 citations

Expression of the neural adhesion molecule L1 in the deafferented dentate gyrus

1996 • 42 citations

Ultrastructural localization of acetylcholinesterase in neurofibrillary tangles, neuropil threads and senile plaques in aged and Alzheimer's brain

1992 • 40 citations

Cholinesterases in the amyloid angiopathy of Alzheimer's disease

1992 • 32 citations

Alzheimer's disease: Is the decrease of the cholinergic innervation of the hippocampus related to intrinsic hippocampal pathology?

1992 • 31 citations

Neocortical infarction in subhuman primates leads to restricted morphological damage of the cholinergic neurons in the nucleus basalis of Meynert

1994 • 22 citations

Acetylcholinesterase-Positive Fiber Deafferentation and Cell Shrinkage in the Septohippocampal Pathway of Aged Amyloid Precursor Protein London Mutant Transgenic Mice

2000 • 6 citations

Pathogenesis and Mechanism of Cerebral Amyloidosis in APP Transgenic Mice

2001 • 1 citations