Abundant Tau Filaments and Nonapoptotic Neurodegeneration in Transgenic Mice Expressing Human P301S Tau Protein

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

2012 • 10,051 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Multilevel Statistical Models

2006 • 5,157 citations

Mammalian MAP kinase signalling cascades

2001 • 5,041 citations

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

1998 • 3,377 citations

Multilevel Statistical Models

1997 • 2,697 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

Neurodegenerative Tauopathies

2001 • 2,276 citations

Protein kinases — the major drug targets of the twenty-first century?

2002 • 2,101 citations

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1998 • 1,440 citations

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1998 • 1,344 citations

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

2000 • 1,311 citations

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.

1988 • 1,073 citations

Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms

1992 • 1,058 citations

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

1989 • 989 citations

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

1996 • 974 citations

Mutation-Specific Functional Impairments in Distinct Tau Isoforms of Hereditary FTDP-17

1998 • 954 citations

Tauopathy in Drosophila : Neurodegeneration Without Neurofibrillary Tangles

2001 • 894 citations

Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization.

1990 • 849 citations

The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

1999 • 701 citations

Structure and novel exons of the human .tau. gene

1992 • 587 citations

Atlas of the Mouse Brain and Spinal Cord

1971 • 582 citations

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

1992 • 563 citations

Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

1999 • 552 citations

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205

1995 • 551 citations

ATLAS OF THE MOUSE BRAIN AND SPINAL CORD

1972 • 537 citations

Epitopes that span the tau molecule are shared with paired helical filaments

1988 • 494 citations

Human Wild-Type Tau Interacts with wingless Pathway Components and Produces Neurofibrillary Pathology in Drosophila

2002 • 474 citations

Tau proteins with FTDP‐17 mutations have a reduced ability to promote microtubule assembly

1998 • 469 citations

Tau Filament Formation in Transgenic Mice Expressing P301L Tau

2001 • 465 citations

Monoclonal antibody PHF‐1 recognizes tau protein phosphorylated at serine residues 396 and 404

1994 • 451 citations

Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform.

1995 • 427 citations

Frontotemporal Dementia and Corticobasal Degeneration in a Family with a P301S Mutation in Tau

1999 • 418 citations

The Structural Basis of Monoclonal Antibody Alz50's Selectivity for Alzheimer's Disease Pathology

1996 • 388 citations

Prominent Axonopathy in the Brain and Spinal Cord of Transgenic Mice Overexpressing Four-Repeat Human tau Protein

1999 • 378 citations

p38 Kinase Is Activated in the Alzheimer's Disease Brain

1999 • 365 citations

Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein

2000 • 355 citations

Activation of p38 Kinase Links Tau Phosphorylation, Oxidative Stress, and Cell Cycle-Related Events in Alzheimer Disease

2000 • 355 citations

Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein

1994 • 349 citations

Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau

1995 • 345 citations

Familial multiple system tauopathy with presenile dementia: A disease with abundant neuronal and glial tau filaments

1997 • 334 citations

A COMPARATIVE STUDY OF MODIFIED BIELSCHOWSKY, BODIAN AND THIOFLAVIN S STAINS ON ALZHEIMER'S NEUROFIBRILLARY TANGLES

1986 • 326 citations

The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bɛ at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase

2001 • 319 citations

Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments

1993 • 312 citations

Straight and paired helical filaments in Alzheimer disease have a common structural unit.

1991 • 310 citations

Sequential phosphorylation of Tau by glycogen synthase kinase‐3β and protein kinase A at Thr212 and Ser214 generates the Alzheimer‐specific epitope of antibody AT100 and requires a paired‐helical‐filament‐like conformation

1998 • 308 citations

Phosphorylation of microtubule‐associated protein tau by stress‐activated protein kinases

1997 • 294 citations

Accelerated filament formation from tau protein with specific FTDP‐17 missense mutations

1999 • 285 citations

Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation

1999 • 283 citations

Tau Pathology in Two Dutch Families with Mutations in the Microtubule-Binding Region of Tau

1998 • 281 citations

p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A₁ Implications for Alzheimer's disease

1992 • 273 citations

Effects of frontotemporal dementia FTDP‐17 mutations on heparin‐induced assembly of tau filaments

1999 • 253 citations

Defective Neurogenesis in Citron Kinase Knockout Mice by Altered Cytokinesis and Massive Apoptosis

2000 • 246 citations

Neurodegeneration with Tau Accumulation in a Transgenic Mouse Expressing V337M Human Tau

2002 • 229 citations

Phosphorylated Map Kinase (ERK1, ERK2) Expression is Associated with Early Tau Deposition in Neurones and Glial Cells, but not with Increased Nuclear DNA Vulnerability and Cell Death, in Alzheimer Disease, Pick's Disease, Progressive Supranuclear Palsy and Corticobasal Degeneration

2001 • 228 citations

Stress‐Activated Protein Kinase/c‐Jun N‐Terminal Kinase Phosphorylates τ Protein

1997 • 213 citations

A Study of Apoptosis in Normal and Pathologic Nervous Tissue After In situ End-Labeling of DNA Strand Breaks

1994 • 205 citations

Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies

2001 • 199 citations

FTDP-17 Mutations in tau Transgenic Mice Provoke Lysosomal Abnormalities and Tau Filaments in Forebrain

2001 • 196 citations

cAMP-Dependent Protein Kinase Phosphorylations on Tau in Alzheimer’s Disease

1999 • 193 citations

FTDP-17: An early-onset phenotype with parkinsonism and epileptic seizures caused by a novel mutation

1999 • 192 citations

Tau Pathology in a Family with Dementia and a P301L Mutation in Tau

1999 • 181 citations

Endogenous Serine Protease Inhibitor Modulates Epileptic Activity and Hippocampal Long-Term Potentiation

1997 • 169 citations

Activation of the JNK/p38 Pathway Occurs in Diseases Characterized by Tau Protein Pathology and Is Related to Tau Phosphorylation But Not to Apoptosis

2001 • 169 citations

TauGene Mutation K257T Causes a Tauopathy Similar to Pick's Disease

2000 • 160 citations

Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein

1996 • 156 citations

AD2, a phosphorylation-dependent monoclonal antibody directed against tau proteins found in Alzheimer's disease

1996 • 150 citations

Formation of Filamentous Tau Aggregations in Transgenic Mice Expressing V337M Human Tau

2001 • 132 citations

Pick's disease associated with the novel Tau gene mutation K369I

2001 • 129 citations

The Genetic and Pathological Classification of Familial Frontotemporal Dementia

2001 • 114 citations

Oligodendroglial tau filament formation in transgenic mice expressing G272V tau

2001 • 103 citations

PHF‐tau from Alzheimer's brain comprises four species on SDS‐PAGE which can be mimicked by in vitro phosphorylation of human brain tau by glycogen synthase kinase‐3β

1994 • 92 citations

Assembly of paired helical filaments from mouse tau: implications for the neurofibrillary pathology in transgenic mouse models for Alzheimer's disease

1999 • 84 citations

A genomic sequence analysis of the mouse and human microtubule-associated protein tau

2001 • 63 citations

Functional effects of tau gene mutations ΔN296 and N296H

2002 • 53 citations

Efficient eukaryotic expression system for authentic human sex hormone-binding globulin

2001 • 44 citations

Diverse cell death pathways result from a single missense mutation in weaver mouse.

1997 • 42 citations

A Japanese patient with frontotemporal dementia and parkinsonism by a tau P301S mutation

2000 • 37 citations

Gene expression profiling of the tau mutant (P301L) transgenic mouse brain

2001 • 28 citations