Reduced Protein Phosphatase 2A Activity Induces Hyperphosphorylation and Altered Compartmentalization of Tau in Transgenic Mice

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

1986 • 1,709 citations

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

2001 • 1,654 citations

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

2001 • 1,268 citations

Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms

1992 • 1,058 citations

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules

1996 • 807 citations

A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

1994 • 726 citations

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease.

1994 • 704 citations

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205

1995 • 551 citations

Phosphorylation that Detaches Tau Protein from Microtubules (Ser262, Ser214) Also Protects It against Aggregation into Alzheimer Paired Helical Filaments

1999 • 520 citations

Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau

1997 • 517 citations

Pin1-Dependent Prolyl Isomerization Regulates Dephosphorylation of Cdc25C and Tau Proteins

2000 • 515 citations

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau.

1992 • 509 citations

Phosphoprotein Phosphatase Activities in Alzheimer Disease Brain

1993 • 504 citations

Tau Filament Formation in Transgenic Mice Expressing P301L Tau

2001 • 465 citations

Phosphatase Activity Toward Abnormally Phosphorylated τ: Decrease in Alzheimer Disease Brain

1995 • 428 citations

Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform.

1995 • 427 citations

Correlations of synaptic and pathological markers with cognition of the elderly

1995 • 405 citations

ALZHEIMER'S DISEASE: Genetic Studies and Transgenic Models

1998 • 401 citations

Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments

1993 • 397 citations

Phosphorylation of Microtubule-associated Protein Tau Is Regulated by Protein Phosphatase 2A in Mammalian Brain

2000 • 396 citations

Regulation of the Phosphorylation State and Microtubule-Binding Activity of Tau by Protein Phosphatase 2A

1996 • 389 citations

Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein

2000 • 355 citations

Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein

1994 • 349 citations

Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau

1995 • 345 citations

Phosphorylation Sites on Tau Identified by Nanoelectrospray Mass Spectrometry

2000 • 343 citations

Protein phosphatase 2A: the Trojan Horse of cellular signaling

2001 • 334 citations

Molecular Interactions among Protein Phosphatase 2A, Tau, and Microtubules

1999 • 293 citations

Neurofibrillary Degeneration in Progressive Supranuclear Palsy and Corticobasal Degeneration

1999 • 284 citations

Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin

2000 • 273 citations

PP2A mRNA Expression Is Quantitatively Decreased in Alzheimer's Disease Hippocampus

2001 • 271 citations

Dephosphorylation of Alzheimer Paired Helical Filaments by Protein Phosphatase-2A and −2B

1995 • 264 citations

Vulnerable neuronal subsets in Alzheimer's and Pick's disease are distinguished by their τ isoform distribution and phosphorylation

1998 • 231 citations

Identification of a New Family of Protein Phosphatase 2A Regulatory Subunits

1995 • 219 citations

Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: focusing on phosphatases.

1995 • 211 citations

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Cα

1998 • 210 citations

Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform

1991 • 206 citations

Role of protein phosphatase‐2A and ‐1 in the regulation of GSK‐3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain

2000 • 185 citations

Ubiquitin in Neurodegenerative Diseases

1993 • 171 citations

Endogenous Serine Protease Inhibitor Modulates Epileptic Activity and Hippocampal Long-Term Potentiation

1997 • 169 citations

High Complexity in the Expression of the B′ Subunit of Protein Phosphatase 2A0

1996 • 163 citations

Tau and transgenic animal models

2001 • 160 citations

AD2, a phosphorylation-dependent monoclonal antibody directed against tau proteins found in Alzheimer's disease

1996 • 150 citations

Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing

1993 • 149 citations

Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcmeurin and phosphatase‐2A

1993 • 146 citations

The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases.

1994 • 138 citations

Paired helical filament-like phosphorylation of tau, deposition of β/A4-amyloid and memory impairment in rat induced by chronic inhibition of phosphatase 1 and 2A

1995 • 132 citations

The regulation of phosphorylation of τ in SY5Y neuroblastoma cells: the role of protein phosphatases

1998 • 114 citations

Argyrophilic grain disease: widespread hyperphosphorylation of tau protein in limbic neurons

1997 • 107 citations

Inhibition of PP‐2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356

2001 • 103 citations

Phosphorylated serine422 on tau proteins is a pathological epitope found in several diseases with neurofibrillary degeneration

1999 • 100 citations

Cytoskeletal Changes in the Brains of Mice Lacking Calcineurin Aα

1997 • 97 citations

Dephosphorylation of microtubule‐associated protein tau by protein phosphatase‐1 and ‐2C and its implication in Alzheimer disease

1994 • 96 citations

Reduced Binding of Protein Phosphatase 2A to Tau Protein with Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 Mutations

2000 • 96 citations

Molecular dissection of the paired helical filament

1995 • 90 citations

Dephosphorylation of phosphopeptides by calcineurin (protein phosphatase 2B)

1994 • 89 citations

Distinct role of protein phosphatase 2A subunit C α in the regulation of E-cadherin and β -catenin during development

2000 • 85 citations

Analysis of subunit isoforms in protein phosphatase 2A holoenzymes from rabbit and Xenopus.

1993 • 84 citations

Site-specific Dephosphorylation of Tau Protein at Ser202/Thr205 in Response to Microtubule Depolymerization in Cultured Human Neurons Involves Protein Phosphatase 2A

1996 • 79 citations

An investigation of the substrate specificity of protein phosphatase 2C using synthetic peptide substrates; comparison with protein phosphatase 2A

1990 • 77 citations

Ser‐262 in human recombinant tau protein is a markedly more favorable site for phosphorylation by CaMKII than PKA or PhK

1998 • 73 citations

Sequence of neurodegeneration and accumulation of phosphorylated tau in cultured neurons after okadaic acid treatment

1999 • 66 citations

Functional Expression of Human PP2Ac in Yeast Permits the Identification of Novel C-terminal and Dominant-negative Mutant Forms

1999 • 66 citations

Differential regulation of a Thy-1 gene in transgenic mice.

1987 • 65 citations

Postmortem changes in the phosphorylation state of tau-protein in the rat brain

1998 • 64 citations

The interrelationship between selective tau phosphorylation and microtubule association

1998 • 62 citations

Overexpressed tau protein in cultured cells is phosphorylated without formation of PHF: implication of phosphoprotein phosphatase involvement

1995 • 59 citations

In situ dephosphorylation of tau by protein phosphatase 2A and 2B in fetal rat primary cultured neurons

1995 • 52 citations

Deregulation of Translational Control of the 65-kDa Regulatory Subunit (PR65α) of Protein Phosphatase 2A Leads to Multinucleated Cells

1995 • 50 citations

Increasing the Ratio of PP2A Core Enzyme to Holoenzyme Inhibits Tat-Stimulated HIV-1 Transcription and Virus Production

1997 • 48 citations

Tau phosphorylation in brain slices: pharmacological evidence for convergent effects of protein phosphatases on tau and mitogen-activated protein kinase.

1995 • 37 citations

Phosphorylation characteristics of the A68 protein in Alzheimer's disease

1990 • 36 citations

The formation of PHF-1 and SMI-31 positive dystrophic neurites in rat hippocampus following acute injection of okadaic acid

2000 • 29 citations

Developmental changes of cyclin dependent kinase 5 subcellular localization in the rat cerebellum

1995 • 22 citations

Important Role for Phylogenetically Invariant PP2Acα Active Site and C-Terminal Residues Revealed by Mutational Analysis in Saccharomyces cerevisiae

2000 • 19 citations

Intracellular ATP slows time-dependent decline of muscarinic cation current in guinea pig ileal smooth muscle

2000 • 16 citations

The Role of Protein Phosphatase 2A Catalytic Subunit Cα in Embryogenesis: Evidence from Sequence Analysis and Localization Studies

1999 • 14 citations

Deafferentation of the hippocampus results in the induction of AT8 positive ‘granules’ in the rat

2001 • 7 citations