Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration

Neurodegenerative Tauopathies

2001 • 2,276 citations

Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP

2001 • 1,543 citations

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1999 • 1,483 citations

Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

2001 • 1,469 citations

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

1991 • 1,397 citations

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

2000 • 1,311 citations

Tau in Alzheimer's disease

1998 • 936 citations

A human peptidyl–prolyl isomerase essential for regulation of mitosis

1996 • 891 citations

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

2001 • 865 citations

The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease

1998 • 845 citations

Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease

1989 • 783 citations

Sequence-Specific and Phosphorylation-Dependent Proline Isomerization: A Potential Mitotic Regulatory Mechanism

1997 • 762 citations

The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

1999 • 701 citations

Abundant Tau Filaments and Nonapoptotic Neurodegeneration in Transgenic Mice Expressing Human P301S Tau Protein

2002 • 673 citations

A Neuronal Antigen in the Brains of Alzheimer Patients

1986 • 577 citations

Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

1999 • 552 citations

Pin1-Dependent Prolyl Isomerization Regulates Dephosphorylation of Cdc25C and Tau Proteins

2000 • 515 citations

Tau Filament Formation in Transgenic Mice Expressing P301L Tau

2001 • 465 citations

Pinning down proline-directed phosphorylation signaling

2002 • 341 citations

Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes

2002 • 328 citations

Genetically engineered mouse models of neurodegenerative diseases

2002 • 232 citations

Mice Lacking Pin1 Develop Normally, but Are Defective in Entering Cell Cycle from G0 Arrest

1999 • 212 citations

Reduced Protein Phosphatase 2A Activity Induces Hyperphosphorylation and Altered Compartmentalization of Tau in Transgenic Mice

2001 • 199 citations

Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases

2000 • 189 citations

Mitotic phosphoepitopes precede paired helical filaments in Alzheimer’s disease

1998 • 177 citations

Proline‐directed phosphorylation and isomerization in mitotic regulation and in Alzheimer's Disease

2003 • 88 citations

The effect of age and Alzheimer's disease on pyramidal neuron density in the individual fields of the hippocampal formation

1992 • 85 citations

Inverse association of Pin1 and tau accumulation in Alzheimer's disease hippocampus

2002 • 83 citations

Mitotic phosphorylation of tau protein in neuronal cell lines resembles phosphorylation in Alzheimer's disease

1998 • 65 citations

Conformation of paired helical filaments blocks dephosphorylation of epitopes shared with fetal tau except Ser199/202 and Ser202/Thr205

2000 • 31 citations