Neurofibrillary Degeneration Can Be Arrested in an In Vivo Cellular Model of Human Tauopathy by Application of a Compound Which Inhibits Tau Filament Formation In Vitro

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1992 • 2,520 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1998 • 1,440 citations

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease

1997 • 1,395 citations

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1994 • 1,313 citations

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

1989 • 904 citations

A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

1994 • 726 citations

β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding

1995 • 580 citations

Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

1999 • 552 citations

The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1995 • 517 citations

Evolution of neuronal changes in the course of Alzheimer’s disease

1998 • 481 citations

Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform.

1995 • 427 citations

Transgenic Expression of the Shortest Human Tau Affects Its Compartmentalization and Its Phosphorylation as in the Pretangle Stage of Alzheimer's Disease

1999 • 194 citations

Autosomal dominant dementia with widespread neurofibrillary tangles

1997 • 179 citations

Microtubular reorganization and dendritic growth response in alzheimer's disease

1989 • 159 citations

Human tau filaments induce microtubule and synapse loss in an in vivo model of neurofibrillary degenerative disease

2000 • 77 citations

Human tau becomes phosphorylated and forms filamentous deposits when overexpressed in lamprey central neurons in situ

1997 • 76 citations

Axotomy-induced neurofilament phosphorylation is inhibited in situ by micromjection of PKA and PKC inhibitors into identified lamprey neurons

1993 • 68 citations

Overexpressed tau protein in cultured cells is phosphorylated without formation of PHF: implication of phosphoprotein phosphatase involvement

1995 • 59 citations

Staging of Neurofibrillary Degeneration Caused by Human Tau Overexpression in a Unique Cellular Model of Human Tauopathy

2001 • 57 citations

The pattern of dendritic sprouting and retraction induced by axotomy of lamprey central neurons

1988 • 46 citations

PHF-Tau from Alzheimer Brain is Rapidly Dephosphorylated and Degraded When Injected into Neurons in situ

1999 • 7 citations