Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1999 • 3,112 citations

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

2000 • 1,954 citations

High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

2000 • 1,793 citations

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

1996 • 1,439 citations

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1998 • 1,336 citations

Microglial response to amyloid plaques in APPsw transgenic mice.

1998 • 580 citations

Inflammation and Alzheimer's disease pathogenesis

1996 • 444 citations

Exposing rats to a predator impairs spatial working memory in the radial arm water maze

1999 • 381 citations

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease.

1996 • 373 citations

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.

1999 • 355 citations

Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes

2001 • 346 citations

The importance of inflammatory mechanisms in alzheimer disease

1998 • 325 citations

Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease.

2000 • 307 citations

Comparison of Neurodegenerative Pathology in Transgenic Mice Overexpressing V717F β-Amyloid Precursor Protein and Alzheimer’s Disease

1996 • 301 citations

Nasal administration of amyloid-? peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease

2000 • 252 citations

Correlation between cognitive deficits and Aβ deposits in transgenic APP+PS1 mice

2001 • 199 citations

Amyloid Phenotype Characterization of Transgenic Mice Overexpressing both Mutant Amyloid Precursor Protein and Mutant Presenilin 1 Transgenes

1999 • 188 citations

Exaggerated astrocyte reactivity after nigrostriatal deafferentation in the aged rat

1997 • 111 citations

Modulation of Alzheimer’s β-amyloid neurotoxicity by site-directed single-chain antibody

2000 • 84 citations