Fas ligation on macrophages enhances IL-1R1–Toll-like receptor 4 signaling and promotes chronic inflammation

Toll-like receptors and innate immunity

2001 • 4,138 citations

Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis

2000 • 2,992 citations

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

1996 • 2,527 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

A Comparison of Etanercept and Methotrexate in Patients with Early Rheumatoid Arthritis

2000 • 1,757 citations

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

2000 • 1,632 citations

Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4

2002 • 1,339 citations

Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

1998 • 1,224 citations

The Extra Domain A of Fibronectin Activates Toll-like Receptor 4

2001 • 1,200 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

INFLIXIMAB AND METHOTREXATE IN THE TREATMENT OF RHEUMATOID ARTHRITIS

2000 • 1,181 citations

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

1996 • 780 citations

Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates.

1981 • 705 citations

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

1998 • 704 citations

Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin‐1 receptor antagonist, in combination with methotrexate: Results of a twenty‐four–week, multicenter, randomized, double‐blind, placebo‐controlled trial

2002 • 629 citations

Interleukin 6 Is Required for the Development of Collagen-induced Arthritis

1998 • 605 citations

Differential Modulation of Apoptosis Sensitivity in CD95 Type I and Type II Cells

1999 • 595 citations

The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signaling pathways

2000 • 556 citations

Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity

1997 • 527 citations

Requirement for Casper (c-FLIP) in Regulation of Death Receptor–Induced Apoptosis and Embryonic Development

2000 • 509 citations

Synovial tissue macrophage populations and articular damage in rheumatoid arthritis

1996 • 507 citations

The apoptotic signaling pathway activated by Toll-like receptor-2

2000 • 487 citations

The Mitochondrial Permeability Transition Is Required for Tumor Necrosis Factor Alpha-Mediated Apoptosis and Cytochrome c Release

1998 • 400 citations

Apoptosis as a therapeutic tool in rheumatoid arthritis

2002 • 377 citations

Activation of NF-κB by FADD, Casper, and Caspase-8

2000 • 291 citations

Matrix Attachment Regulates FAS-Induced Apoptosis in Endothelial Cells

2001 • 284 citations

Type ii collagen—induced arthritis in mice

1984 • 281 citations

Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody.

1993 • 278 citations

Activation of the NF-κB pathway by Caspase 8 and its homologs

2000 • 234 citations

FAS Engagement Induces the Maturation of Dendritic Cells (Dcs), the Release of Interleukin (Il)-1β, and the Production of Interferon γ in the Absence of IL-12 during Dc–T Cell Cognate Interaction

2000 • 230 citations

Flice-Inhibitory Protein Expression during Macrophage Differentiation Confers Resistance to FAS-Mediated Apoptosis

1999 • 229 citations

Regulation of IL-6 and IL-8 Expression in Rheumatoid Arthritis Synovial Fibroblasts: the Dominant Role for NF-κB But Not C/EBPβ or c-Jun

2000 • 210 citations

Constitutively Activated Akt-1 Is Vital for the Survival of Human Monocyte-Differentiated Macrophages

2001 • 209 citations

TNF-α Gene Expression in Macrophages: Regulation by NF-κB Is Independent of c-Jun or C/EBPβ

2000 • 204 citations

Interleukin 1 Receptor Dependence of Serum Transferred Arthritis Can be Circumvented by Toll-like Receptor 4 Signaling

2003 • 190 citations

Free Cholesterol Loading of Macrophages Induces Apoptosis Involving the Fas Pathway

2000 • 183 citations

Fas (CD95) Induces Proinflammatory Cytokine Responses by Human Monocytes and Monocyte-Derived Macrophages

2003 • 176 citations

Macrophages Require Constitutive NF-κB Activation To Maintain A1 Expression and Mitochondrial Homeostasis

2000 • 153 citations

Apoptosis, fas and systemic autoimmunity: the MRL-Ipr/Ipr model

1994 • 151 citations

The CD95 (APO-1/Fas) Receptor Activates NF- B Independently of Its Cytotoxic Function

1996 • 146 citations

Dominant-negative FADD inhibits TNFR60-, Fas/Apo1- and TRAIL-R/Apo2-mediated cell death but not gene induction

1998 • 144 citations

Evaluation of TNF-α and IL-1 Blockade in Collagen-Induced Arthritis and Comparison with Combined Anti-TNF-α/Anti-CD4 Therapy

2000 • 119 citations

Adhesion-Mediated Intracellular Redistribution of c-Fas-Associated Death Domain-Like IL-1-Converting Enzyme-Like Inhibitory Protein-Long Confers Resistance to CD95-Induced Apoptosis in Hematopoietic Cancer Cell Lines

2002 • 118 citations

Rheumatoid arthritis synovial macrophages express the Fas-associated death domain-like interleukin-1?-converting enzyme-inhibitory protein and are refractory to Fas-mediated apoptosis

2001 • 112 citations

T cell-specific FADD-deficient mice: FADD is required for early T cell development

2001 • 110 citations

Non-apoptotic Signaling Pathways Activated by Soluble Fas Ligand in Serum-starved Human Fibroblasts

2001 • 93 citations

Oral Administration of Lipopolysaccharide Exacerbates Collagen-Induced Arthritis in Mice

1999 • 68 citations

Gene-Expression Profile of Collagen-induced Arthritis

2002 • 62 citations

The Fas-associated death domain protein suppresses activation of NF-κB by LPS and IL-1β

2002 • 62 citations

The Fas-associated death domain protein suppresses activation of NF-κB by LPS and IL-1β

2002 • 58 citations

Isolation and Analysis of Components of CD95 (APO-1/Fas) Death-Inducing Signaling Complex

1999 • 55 citations

Pathogen-Associated Molecular Patterns Sensitize Macrophages to Fas Ligand-Induced Apoptosis and IL-1β Release

2003 • 50 citations

Calcium Channel Blockers Activate the Interleukin-6 Gene Via the Transcription Factors NF-IL6 and NF-κB in Primary Human Vascular Smooth Muscle Cells

1999 • 48 citations

Differential requirement for NF-κB-inducing kinase in the induction of NF-κB by IL-1β, TNF-α, and Fas

2002 • 37 citations

Mice transgenic for intracellular interleukin‐1 receptor antagonist type 1 are protected from collagen‐induced arthritis

2003 • 32 citations