Expression of the functional soluble form of human fas ligand in activated lymphocytes.

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

1984 • 1,738 citations

The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response

1989 • 1,679 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

Processing of tumour necrosis factor-α precursor by metalloproteinases

1994 • 1,200 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

1988 • 1,105 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

1993 • 1,073 citations

Fas and Fas ligand: lpr and gld mutations

1995 • 906 citations

Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.

1992 • 857 citations

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.

1992 • 839 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

Tumor necrosis factor Characterization at the molecular, cellular and in vivo level

1991 • 708 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells.

1993 • 643 citations

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

1994 • 607 citations

Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor

1994 • 571 citations

Purification and characterization of the Fas-ligand that induces apoptosis.

1994 • 521 citations

Structure of tumour necrosis factor

1989 • 512 citations

The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.

1989 • 511 citations

Human Fas ligand: gene structure, chromosomal location and species specificity

1994 • 435 citations

Unraveling Function in the TNF Ligand and Receptor Families

1994 • 431 citations

The active form of tumor necrosis factor is a trimer.

1987 • 430 citations

Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.

1993 • 410 citations

A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact

1990 • 409 citations

Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity.

1994 • 386 citations

Immunohistochemical detection of Fas antigen in liver tissue of patients with chronic hepatitis C

1994 • 363 citations

Fas and Fas Ligand: A Death Factor and Its Receptor

1994 • 354 citations

Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

1994 • 307 citations

Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity.

1994 • 294 citations

Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens.

1992 • 282 citations

Isolation and characterization of the cDNA for murine granulocyte colony-stimulating factor.

1986 • 188 citations

The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution.

1992 • 187 citations

Purification and characterization of the receptor for murine granulocyte colony-stimulating factor.

1990 • 180 citations

High expression of APO-1 (CD95) on T lymphocytes from human immunodeficiency virus-1-infected children [letter]

1994 • 174 citations

Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated, mature T cells

1993 • 146 citations

A novel addition to the T cell repertory. Cell surface expression of tumor necrosis factor/cachectin by activated normal human T cells.

1990 • 133 citations

APO-1-induced apoptosis of leukemia cells from patients with adult T- cell leukemia

1993 • 131 citations

Anti-Fas monoclonal antibody is cytocidal to human immunodeficiency virus-infected cells without augmenting viral replication.

1990 • 127 citations

Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders.

1995 • 117 citations

Lymphotoxin is expressed as a heteromeric complex with a distinct 33-kDa glycoprotein on the surface of an activated human T cell hybridoma.

1992 • 97 citations

Alternative Cleavage of the Cachectin/Tumor Necrosis Factor Propeptide Results in a Larger, Inactive Form of Secreted Protein

1989 • 75 citations

Antibodies against amino acids 1-15 of tumor necrosis factor block its binding to cell-surface receptor.

1987 • 38 citations

Establishment of apoptosis‐inducing monoclonal antibody 2D1 and 2D1‐resistant variants of human T cell lines

1993 • 30 citations