Autoimmune lymphoproliferative syndromes: genetic defects of apoptosis pathways

Caspases: Enemies Within

1998 • 6,923 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

Apoptosis by Death Factor

1997 • 5,038 citations

The Fas Death Factor

1995 • 4,070 citations

The TNF and TNF Receptor Superfamilies

2001 • 3,533 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity

1995 • 1,306 citations

RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

1995 • 964 citations

Fas and Fas ligand: lpr and gld mutations

1995 • 906 citations

A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen

1993 • 857 citations

Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

1997 • 797 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

1998 • 704 citations

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

2002 • 685 citations

Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations

2000 • 650 citations

Inherited Human Caspase 10 Mutations Underlie Defective Lymphocyte and Dendritic Cell Apoptosis in Autoimmune Lymphoproliferative Syndrome Type II

1999 • 631 citations

In Vivo Detection of Dendritic Cell Antigen Presentation to CD4+ T Cells

1997 • 560 citations

Death Receptor Recruitment of Endogenous Caspase-10 and Apoptosis Initiation in the Absence of Caspase-8

2001 • 521 citations

FasGene Mutations in the Canale–Smith Syndrome, an Inherited Lymphoproliferative Disorder Associated with Autoimmunity

1996 • 486 citations

Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease.

1996 • 473 citations

CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells

1995 • 470 citations

The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis

2001 • 454 citations

The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity

2000 • 440 citations

Molecular Ordering of the Initial Signaling Events of CD95

2002 • 387 citations

Caspase-10 is an initiator caspase in death receptor signaling

2001 • 387 citations

Regulation of lymphocyte proliferation and death by flip

2001 • 385 citations

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver

1995 • 377 citations

Clinical, Immunologic, and Genetic Features of an Autoimmune Lymphoproliferative Syndrome Associated With Abnormal Lymphocyte Apoptosis

1997 • 374 citations

An Inherited Disorder of Lymphocyte Apoptosis: The Autoimmune Lymphoproliferative Syndrome

1999 • 291 citations

Mutations in the Fas Antigen in Patients With Multiple Myeloma

1997 • 228 citations

Pathological Findings in Human Autoimmune Lymphoproliferative Syndrome

1998 • 223 citations

Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr mice.

1998 • 221 citations

Autoimmune Lymphoproliferative Syndrome with Defective Fas: Genotype Influences Penetrance

1999 • 210 citations

A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis.

1995 • 194 citations

Clinical, immunological, and pathological consequences of Fas-deficient conditions

1996 • 184 citations

Mutations in the Fas Antigen in Patients With Multiple Myeloma

1997 • 183 citations

Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia

1999 • 179 citations

Missense mutations in the Fas gene resulting in autoimmune lymphoproliferative syndrome: a molecular and immunological analysis.

1997 • 177 citations

Missense Mutations in the Fas Gene Resulting in Autoimmune Lymphoproliferative Syndrome: A Molecular and Immunological Analysis

1997 • 168 citations

Chronic lymphadenopathy simulating malignant lymphoma

1966 • 159 citations

The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo-1) mutations

1999 • 156 citations

Lymphoproliferative syndrome with autoimmunity: A possible genetic basis for dominant expression of the clinical manifestations.

1999 • 148 citations

Immunophenotypic profiles in families with autoimmune lymphoproliferative syndrome

2001 • 142 citations

CD95 (APO-1/Fas) Mutations in Childhood T-Lineage Acute Lymphoblastic Leukemia

1998 • 121 citations

DR3 Regulates Negative Selection during Thymocyte Development

2001 • 114 citations

The clinical spectrum in a large kindred with autoimmune lymphoproliferative syndrome caused by a Fas mutation that impairs lymphocyte apoptosis

1998 • 112 citations

Increases in circulating and lymphoid tissue interleukin-10 in autoimmune lymphoproliferative syndrome are associated with disease expression

2001 • 112 citations

Characteristic T helper 2 T cell cytokine abnormalities in autoimmune lymphoproliferative syndrome, a syndrome marked by defective apoptosis and humoral autoimmunity.

1997 • 110 citations

Novel Fas (CD95/APO-1) mutations in infants with a lymphoproliferative disorder.

1998 • 99 citations

Enhanced CD4+ T Cell Proliferation and Th2 Cytokine Production in DR6-Deficient Mice

2001 • 84 citations

Fas/Apo1 mutations and autoimmune lymphoproliferative syndrome in a patient with type 2 autoimmune hepatitis

1997 • 62 citations

Autoimmune Lymphoproliferative Syndrome (ALPS) in a Child from Consanguineous Parents: A Dominant or Recessive Disease?

2000 • 61 citations

Response to steroid therapy in autism secondary to autoimmune lymphoproliferative syndrome

2000 • 60 citations

Correction of Fas (CD95) deficiency by haploidentical bone marrow transplantation

1997 • 57 citations

Impaired c-Jun Amino Terminal Kinase Activity and T Cell Differentiation in Death Receptor 6–deficient Mice

2001 • 54 citations

Defective Function of Fas in Patients With Type 1 Diabetes Associated With Other Autoimmune Diseases

2001 • 52 citations

Identification of New Fas Mutations in a Patient with Autoimmune Lymphoproliferative Syndrome (ALPS) and Eosinophilia

1999 • 35 citations

Dyserythropoiesis associated with a Fas‐deficient condition in childhood

2000 • 35 citations

Autoimmune Lymphoproliferative Syndrome: A Syndrome Associated with Inherited Genetic Defects That Impair Lymphocytic Apoptosis—CT and US Features

1999 • 32 citations

Diffuse large B‐cell non‐Hodgkin's lymphoma in a patient with autoimmune lymphoproliferative syndrome

2001 • 20 citations

The Autoimmune Lymphoproliferative Syndrome

2001 • 19 citations

Cytomegalovirus infection in infants with autoimmune lymphoproliferative syndrome (ALPS)

2000 • 17 citations

Characterization of lymphoproliferation induced by interactions between Ipr and gld genes

1991 • 9 citations

Molecular Genetic Studies in Lymphocyte Apoptosis and Human Autoimmunity

2007 • 8 citations