Effective Treatment of Established Murine Collagen-Induced Arthritis by Systemic Administration of Dendritic Cells Genetically Modified to Express IL-4

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Interleukin-10

1993 • 1,820 citations

Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases

1995 • 1,120 citations

Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia.

1993 • 821 citations

Construction of adenovirus vectors through Cre-lox recombination

1997 • 807 citations

Interleukin (IL)-10 Inhibits Nuclear Factor кB (NFкB) Activation in Human Monocytes

1995 • 698 citations

How important are t cells in chronic rheumatoid synovitis?

1990 • 553 citations

NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint

1998 • 462 citations

Role of interleukin‐4 and interleukin‐10 in murine collagen‐induced arthritis. Protective effect of interleukin‐4 and interleukin‐10 treatment on cartilage destruction

1997 • 404 citations

In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon.

1987 • 396 citations

COSTIMULATORY MOLECULE-DEFICIENT DENDRITIC CELL PROGENITORS (MHC CLASS II+, CD80dim, CD86-) PROLONG CARDIAC ALLOGRAFT SURVIVAL IN NONIMMUNOSUPPRESSED RECIPIENTS12

1996 • 378 citations

Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion.

1996 • 330 citations

Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor α soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects

1998 • 285 citations

BONE MARROW-DERIVED DENDRITIC CELL PROGENITORS (NLDC 145+, MHC CLASS II+, B7-1dim, B7-2−) INDUCE ALLOANTIGEN-SPECIFIC HYPORESPONSIVENESS IN MURINE T LYMPHOCYTES1,2

1995 • 281 citations

Dendritic Cells Genetically Engineered to Express Fas Ligand Induce Donor-Specific Hyporesponsiveness and Prolong Allograft Survival

2000 • 237 citations

Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor ?B decoy oligodeoxynucleotides as a gene therapy

1999 • 221 citations

Adenoviral Transfer of the Viral IL-10 Gene Periarticularly to Mouse Paws Suppresses Development of Collagen-Induced Arthritis in Both Injected and Uninjected Paws

1999 • 204 citations

Adenoviral Vector-Mediated Overexpression of IL-4 in the Knee Joint of Mice with Collagen-Induced Arthritis Prevents Cartilage Destruction

1999 • 179 citations

Suppression of monocyte function and differential regulation of IL-1 and IL-1ra by IL-4 contribute to resolution of experimental arthritis.

1993 • 173 citations

Induction of antigen-specific immunosuppression by CD95L cDNA-transfected 'killer' dendritic cells

1999 • 159 citations

Treatment with gamma-interferon triggers the onset of collagen arthritis in mice

1988 • 158 citations

Direct Adenoviral Gene Transfer of Viral IL-10 to Rabbit Knees with Experimental Arthritis Ameliorates Disease in Both Injected and Contralateral Control Knees

1999 • 145 citations

Prolongation of Cardiac Allograft Survival Using Dendritic Cells Treated with NF-κB Decoy Oligodeoxyribonucleotides

2000 • 141 citations

Induction of Specific T Cell Tolerance by Fas Ligand- Expressing Antigen-Presenting Cells

1999 • 131 citations

Interleukin‐4 inhibits bone resorption through an effect on osteoclasts and proinflammatory cytokines in an ex vivo model of bone resorption in rheumatoid arthritis

1994 • 107 citations

Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4

2000 • 100 citations

Viral IL-10 and Soluble TNF Receptor Act Synergistically to Inhibit Collagen-Induced Arthritis Following Adenovirus- Mediated Gene Transfer

2000 • 92 citations

The role of interleukin 2 in autoimmunity

1989 • 89 citations

Ex vivo treatment of antigen-presenting cells with CTLA4Ig and encephalitogenic peptide prevents experimental autoimmune encephalomyelitis in the Lewis rat.

1996 • 74 citations

Collagen-induced arthritis in mice. Relationship of collagen-specific and total IgE synthesis to disease.

1991 • 59 citations

Interleukin‐4 but not interleukin‐10 inhibits the production of leukemia inhibitory factor by rheumatoid synovium and synoviocytes

1994 • 55 citations

Gene Therapy of Arthritis.

1999 • 49 citations

Interleukin 4, but not Interleukin 10, Regulates the Production of Inflammation Mediators by Rheumatoid Synoviocytes

1995 • 33 citations

Blocking cytokines with genes

1998 • 28 citations

T cells from autoimmune "IL 2-defective" MRL-lpr/lpr mice continue to grow in vitro and produce IL 2 constitutively.

1984 • 27 citations

Interleukin-4 (IL-4) induces down-modulation and shedding of the p55 tumour necrosis factor receptor and inhibits TNF ?'s effect on rheumatoid synovial fibroblasts

1994 • 25 citations

Evidence for multiple CD95–CD95 ligand interactions in anteriorchamber‐associated immune deviation induced by soluble protein antigen

2000 • 18 citations