Immune privilege or inflammation? Insights into the Fas ligand enigma

The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand.

1996 • 894 citations

Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction

1997 • 453 citations

Regulation of the Proinflammatory Effects of Fas Ligand (CD95L)

1998 • 391 citations

The Fas Counterattack In Vivo: Apoptotic Depletion of Tumor-Infiltrating Lymphocytes Associated with Fas Ligand Expression by Human Esophageal Carcinoma

1998 • 331 citations

Expression of APO‐1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium

1994 • 310 citations

Unraveling Immune Privilege

1995 • 302 citations

The role of FasL-induced apoptosis in immune privilege

1997 • 262 citations

Expression of Fas ligand in liver metastases of human colonic adenocarcinomas

1997 • 259 citations

Not so Fas: Re-evaluating the mechanisms of immune privilege and tumor escape

2000 • 256 citations

The Fas counterattack: cancer as a site of immune privilege

1999 • 240 citations

Opposing Effects of Transmembrane and Soluble FAS Ligand Expression on Inflammation and Tumor Cell Survival

2000 • 236 citations

Fas/FADD-mediated activation of a specific program of inflammatory gene expression in vascular smooth muscle cells

2000 • 200 citations

Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids

1999 • 176 citations

Induction of antigen-specific immunosuppression by CD95L cDNA-transfected 'killer' dendritic cells

1999 • 159 citations

Fas-Mediated Suicide of Tumor-Reactive T Cells Following Activation by Specific Tumor: Selective Rescue by Caspase Inhibition

1999 • 126 citations

Fas ligand expression in primary colon adenocarcinomas: evidence that the Fas counterattack is a prevalent mechanism of immune evasion in human colon cancer

1998 • 122 citations

Prognostic relevance of altered Fas (CD95)-system in human breast cancer

2000 • 106 citations

FAS LIGAND GENE TRANSFER TO RENAL ALLOGRAFTS IN RATS

1998 • 106 citations

FasL:Fas ratio--a prognostic factor in breast carcinomas.

2000 • 99 citations

Frequency of apoptosis of tumor-infiltrating lymphocytes induced by fas counterattack in human colorectal carcinoma and its correlation with prognosis.

2000 • 99 citations

Fas/Fas Ligand Interaction in Human Colorectal Hepatic Metastases

1999 • 96 citations

Constitutive Expression of FasL in Thyrocytes

1998 • 90 citations

Regulation of Fas ligand expression in breast cancer cells by estrogen: functional differences between estradiol and tamoxifen

2000 • 85 citations

FasL is more frequently expressed in liver metastases of colorectal cancer than in matched primary carcinomas

1999 • 83 citations

Prognostic significance of Fas and Fas ligand expressions in human esophageal cancer.

1999 • 81 citations

The status of Fas and Fas ligand expression can predict recurrence of hepatocellular carcinoma

2000 • 77 citations

Expressions of Fas ligand and other apoptosis-related genes and their prognostic significance in epithelial ovarian neoplasms

2000 • 73 citations

PROLONGED SURVIVAL OF RAT LIVER ALLOGRAFTS TRANSFECTED WITH FAS LIGAND-EXPRESSING PLASMID1

1998 • 66 citations

True

2000 • 62 citations

Interleukin 1 and interleukin 1β converting enzyme (caspase 1) expression in the human colonic epithelial barrier. Caspase 1 downregulation in colon cancer

1999 • 59 citations

Chronic lymphocytic leukemia B cells inhibit spontaneous Ig production by autologous bone marrow cells: role of CD95-CD95L interaction

2000 • 50 citations

Fas and Fas ligand expression in tumor cells and in vascular smooth-muscle cells of colonic and renal carcinomas

1999 • 45 citations

Contribution of CD95 Ligand-Induced Neutrophil Infiltration to the Bystander Effect in p53 Gene Therapy for Human Cancer

2000 • 42 citations

Depletion of the Natural Killer Cell Population in the Peritoneum by AK-5 Tumor Cells Overexpressing Fas-Ligand: A Mechanism of Immune Evasion

1998 • 32 citations

Fas (APO-1/CD95) ligand and Fas expression in renal cell carcinomas: Correlation with the prognostic factors

2000 • 27 citations

Fas (APO-1/CD95) Ligand and Fas Expression in Renal Cell Carcinomas

2000 • 24 citations

Expression of Fas and Fas Ligand and Apoptosis in Tumor-Associated Lymphocytes and in Tumor Cells from Malignant Pleural Effusions

1998 • 20 citations

Tumor-derived Fas ligand induces toxicity in lymphoid organs and plays an important role in successful chemotherapy

2000 • 15 citations

Massive acinar cell apoptosis with secondary necrosis, origin of ducts in atrophic lobules and failure to regenerate in cyanohydroxybutene pancreatopathy in rats

1999 • 14 citations

CM101 treatment overrides tumor-induced immunoprivilege leading to apoptosis.

2000 • 13 citations

Evidence for Fas counter attack in vivo from a study of colorectal cancer.

2000 • 6 citations