Secretory lysosomes

Rab proteins as membrane organizers

2001 • 3,320 citations

B lymphocytes secrete antigen-presenting vesicles.

1996 • 3,198 citations

Dendritic Cells

2001 • 2,164 citations

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

1998 • 2,078 citations

Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and -Granules

1999 • 1,379 citations

Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes.

1985 • 1,153 citations

Selective Enrichment of Tetraspan Proteins on the Internal Vesicles of Multivesicular Endosomes and on Exosomes Secreted by Human B-lymphocytes

1998 • 1,153 citations

SNARE-mediated membrane fusion

2001 • 1,121 citations

STRUCTURE AND FUNCTION OF THE MANNOSE 6-PHOSPHATE/INSULINLIKE GROWTH FACTOR II RECEPTORS

1992 • 1,056 citations

Plasma Membrane Repair Is Mediated by Ca2+-Regulated Exocytosis of Lysosomes

2001 • 966 citations

A Role for a 70-Kilodalton Heat Shock Protein in Lysosomal Degradation of Intracellular Proteins

1989 • 932 citations

A Receptor for the Selective Uptake and Degradation of Proteins by Lysosomes

1996 • 904 citations

Biosynthesis of lysosomal enzymes in fibroblasts. Synthesis as precursors of higher molecular weight.

1980 • 809 citations

The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors

2001 • 773 citations

Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border.

1985 • 738 citations

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes.

1991 • 693 citations

Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus

1994 • 676 citations

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

1991 • 663 citations

Expression of the Fas ligand in cells of T cell lineage.

1995 • 659 citations

Identification and mutation analysis of the complete gene for Chediak–Higashi syndrome

1996 • 536 citations

Adaptor-related proteins

2001 • 531 citations

Transport of Peptide-MHC Class II Complexes in Developing Dendritic Cells

2000 • 483 citations

A small GTP-binding protein dissociates from synaptic vesicles during exocytosis

1991 • 441 citations

The melanosome: membrane dynamics in black and white

2001 • 441 citations

Distinct Protein Sorting and Localization to Premelanosomes, Melanosomes, and Lysosomes in Pigmented Melanocytic Cells✪

2001 • 437 citations

The Pigmentary System: Physiology and Pathophysiology

1999 • 426 citations

Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes

2001 • 415 citations

The Formation of Immunogenic Major Histocompatibility Complex Class II–Peptide Ligands in Lysosomal Compartments of Dendritic Cells Is Regulated by Inflammatory Stimuli

2000 • 412 citations

Visualization of Melanosome Dynamics within Wild-Type and Dilute Melanocytes Suggests a Paradigm for Myosin V Function In Vivo

1998 • 407 citations

Biosynthesis of lysosomal enzymes in fibroblasts. Phosphorylation of mannose residues.

1980 • 404 citations

A mutation in Rab27a causes the vesicle transport defects observed in ashen mice

2000 • 402 citations

Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells

1999 • 385 citations

Caenorhabditis elegans rab-3Mutant Synapses Exhibit Impaired Function and Are Partially Depleted of Vesicles

1997 • 373 citations

A molecular chaperone complex at the lysosomal membrane is required for protein translocation

2001 • 362 citations

Regulated secretion of conventional lysosomes

2000 • 338 citations

Rab27a Regulates the Peripheral Distribution of Melanosomes in Melanocytes

2001 • 326 citations

A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3

1998 • 298 citations

Synaptotagmin VII Regulates Ca2+-Dependent Exocytosis of Lysosomes in Fibroblasts

2000 • 298 citations

Mannose 6–Phosphate Receptors Are Sorted from Immature Secretory Granules via Adaptor Protein AP-1, Clathrin, and Syntaxin 6–positive Vesicles

1998 • 290 citations

Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells

2001 • 285 citations

Regulation of Lamp2a Levels in the Lysosomal Membrane

2000 • 275 citations

Platelet Dense Granules

1999 • 274 citations

Melanosomes Are Specialized Members of the Lysosomal Lineage of Organelles

1995 • 270 citations

Relocation of the t-SNARE SNAP-23 from Lamellipodia-like Cell Surface Projections Regulates Compound Exocytosis in Mast Cells

1998 • 254 citations

Molecules relevant for T cell‐target cell interaction are present in cytolytic granules of human T lymphocytes

1989 • 251 citations

Mutations in Mlph , encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden mice

2001 • 249 citations

Actin- and microtubule-dependent organelle motors: interrelationships between the two motility systems

1995 • 245 citations

Defective Granule Exocytosis in Rab27a-Deficient Lymphocytes from Ashen Mice

2001 • 245 citations

The trans-Golgi network: a late secretory sorting station

1997 • 235 citations

Dense core lysosomes can fuse with late endosomes and are re-formed from the resultant hybrid organelles

1997 • 234 citations

Myosin V associates with melanosomes in mouse melanocytes: evidence that myosin V is an organelle motor

1997 • 227 citations

Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re‐filling of the lytic granules and secretion of lytic proteins via a non‐granule pathway

1995 • 220 citations

Soluble NSF Attachment Protein Receptors (SNAREs) in RBL-2H3 Mast Cells: Functional Role of Syntaxin 4 in Exocytosis and Identification of a Vesicle-Associated Membrane Protein 8-Containing Secretory Compartment

2000 • 218 citations

Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface.

1996 • 210 citations

The molecular machinery for lysosome biogenesis*

2001 • 209 citations

The Tyrosinase Gene and Oculocutaneous Albinism Type 1 (OCA1): A Model for Understanding the Molecular Biology of Melanin Formation

2000 • 207 citations

Asparagine-linked Oligosaccharides Protect Lamp-1 and Lamp-2 from Intracellular Proteolysis

1999 • 194 citations

Mouse Models of Hermansky Pudlak Syndrome: A Review

1998 • 192 citations

Molecular control of neural crest formation, migration and differentiation

2000 • 175 citations

Differential Sorting of Lysosomal Enzymes Out of the Regulated Secretory Pathway in Pancreatic β-Cells

1997 • 166 citations

Biosynthesis, processing and sorting of neutrophil proteins: insight into neutrophil granule development

1997 • 163 citations

Fas ligand is targeted to secretory lysosomes via a proline-rich domain in its cytoplasmic tail

2001 • 161 citations

Rab geranylgeranyl transferase α mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis

2000 • 158 citations

Regulation of Cell Surface Expression of CTLA-4 by Secretion of CTLA-4-Containing Lysosomes Upon Activation of CD4+ T Cells

2000 • 146 citations

Mannose 6-phosphate-independent targeting of lysosomal enzymes in I-cell disease B lymphoblasts.

1993 • 144 citations

The biogenesis of lysosomes: Is it a kiss and run, continuous fusion and fission process?

1996 • 144 citations

Subcellular distribution of docking/fusion proteins in neutrophils, secretory cells with multiple exocytic compartments.

1995 • 144 citations

Analysis of the Lysosomal Storage Disease Chediak–Higashi Syndrome

2000 • 123 citations

Role of Calcium Influx in Cytotoxic T Lymphocyte Lytic Granule Exocytosis during Target Cell Killing

2001 • 121 citations

Molecular and Cellular Biology of Mast Cells and Basophils

1997 • 119 citations

Two Genes Are Responsible for Griscelli Syndrome at the Same 15q21 Locus

2000 • 118 citations

Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition.

1996 • 115 citations

The src-family protein-tyrosine kinase p59hck is located on the secretory granules in human neutrophils and translocates towards the phagosome during cell activation

1995 • 111 citations

Functions of unconventional myosins

2000 • 111 citations

Synaptotagmin II Negatively Regulates Ca2+-triggered Exocytosis of Lysosomes in Mast Cells

1999 • 110 citations

Involvement of the ras-like GTPase rab3d in RBL-2H3 mast cell exocytosis following stimulation via high affinity IgE receptors (Fc epsilonRI).

1997 • 106 citations

Identification of mutations in two major mRNA isoforms of the Chediak- Higashi syndrome gene in human and mouse

1997 • 103 citations

Rat Basophilic Leukemia Cells Express Syntaxin-3 and VAMP-7 in Granule Membranes

2000 • 103 citations

Lytic granules from cytotoxic T cells exhibit kinesin-dependent motility on microtubules in vitro

1993 • 96 citations

Secretory Lysosome Biogenesis in Cytotoxic T Lymphocytes from Normal and Chediak Higashi Syndrome Patients

2000 • 89 citations

Sorting and Targeting of Melanosomal Membrane Proteins: Signals, Pathways, and Mechanisms

2000 • 73 citations

Comparison of the Effects on Secretion in Chromaffin and PC12 Cells of Rab3 Family Members and Mutants

1999 • 73 citations

Rab3a and SNARE Proteins: Potential Regulators of Melanosome Movement

2001 • 61 citations

Rab3D, a Small GTPase, Is Localized on Mast Cell Secretory Granules and Translocates to the Plasma Membrane upon Exocytosis

1999 • 54 citations

PDZ Domain Protein GIPC Interacts with the Cytoplasmic Tail of Melanosomal Membrane Protein gp75 (Tyrosinase-related Protein-1)

2001 • 53 citations

The activation of resting lymphocytes is accompanied by the biogenesis of lysosomal organelles

1990 • 36 citations

Small GTPase Rab3A is Associated with Melanosomes in Melanoma Cells

2000 • 34 citations

Normal and abnormal secretion by haemopoietic cells

2001 • 31 citations

Diffuse vesicular distribution of Rab3D in the polarized neuroendocrine cell line AtT‐20

1995 • 31 citations

Melanocyte Differentiation Marker gp75, the Brown Locus Protein, Can Be Regulated Independently of Tyrosinase and Pigmentation

1995 • 30 citations

Identification of a novel myosin-Va mutation in an ataxic mutant rat, dilute-opisthotonus

2000 • 26 citations

Isolation of a murine cDNA clone encoding Rab 19, a novel tissue-specific small GTPase

1995 • 25 citations

Cutting Edge: Ca2+-Dependent Exocytosis in Mast Cells Is Stimulated by the Ca2+ Sensor, Synaptotagmin I

1998 • 23 citations

Lysosomal enzyme secretory mutants of Dictyostelium discoideum

1990 • 12 citations