Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor¹

Protein modules and signalling networks

1995 • 2,447 citations

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

1996 • 828 citations

SH3 domains: complexity in moderation

2001 • 778 citations

Structural basis for phosphoserine-proline recognition by group IV WW domains.

2000 • 677 citations

Expression of the Fas ligand in cells of T cell lineage.

1995 • 659 citations

A WW domain-containing Yes-associated protein (YAP) is a novel transcriptional co-activator

1999 • 534 citations

Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains

1994 • 519 citations

CD40 ligand-transduced co-stimulation of T cells in the development of helper function

1995 • 425 citations

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

1995 • 398 citations

Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells

1999 • 385 citations

NeW Wrinkles for an Old Domain

2000 • 349 citations

Activated Human T Cells Release Bioactive Fas Ligand and APO2 Ligand in Microvesicles

1999 • 302 citations

CD40 preferentially costimulates activation of CD4+ T lymphocytes.

1994 • 255 citations

Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan.

2000 • 255 citations

The WW Domain of Neural Protein FE65 Interacts with Proline-rich Motifs in Mena, the Mammalian Homolog of DrosophilaEnabled

1997 • 243 citations

Maximal Proliferation of Cytotoxic T Lymphocytes Requires Reverse Signaling through Fas Ligand

1998 • 217 citations

FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands

1997 • 208 citations

A casein kinase I motif present in the cytoplasmic domain of members of the tumour necrosis factor ligand family is implicated in `reverse signalling'

1999 • 198 citations

Reverse Signaling Through Transmembrane TNF Confers Resistance to Lipopolysaccharide in Human Monocytes and Macrophages

2000 • 195 citations

CD137 (ILA/4-1BB), a Member of the TNF Receptor Family, Induces Monocyte Activation via Bidirectional Signaling

1998 • 189 citations

Cd40 Ligand (Cd154) Triggers a Short-Term Cd4+ T Cell Activation Response That Results in Secretion of Immunomodulatory Cytokines and Apoptosis

2000 • 187 citations

Reverse signaling via CD30 ligand.

1996 • 184 citations

Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.

1993 • 178 citations

Two-step TCRζ/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyrosine and lipid kinases

1994 • 176 citations

Functions of WW domains in the nucleus

2001 • 166 citations

Fas ligand is targeted to secretory lysosomes via a proline-rich domain in its cytoplasmic tail

2001 • 161 citations

Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase.

1993 • 142 citations

Aberrant expression and reverse signalling of CD70 on malignant B cells

1999 • 132 citations

Outside-to-Inside Signal Through the Membrane TNF-α Induces E-Selectin (CD62E) Expression on Activated Human CD4+ T Cells

2001 • 128 citations

Lymphocytes with a complex: adapter proteins in antigen receptor signaling

2000 • 127 citations

A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK

1998 • 124 citations

The WW Domain of Dystrophin Requires EF-Hands Region to Interact with β-Dystroglycan

1999 • 123 citations

The dual functions of Fas ligand in the regulation of peripheral CD8⁺and CD4⁺T cells

2000 • 123 citations

Interactions between the components of the human nadph oxidase: intrigues in the phox family

1996 • 121 citations

Fas Ligand Costimulates the In Vivo Proliferation of CD8+ T Cells

2000 • 113 citations

Newly discovered role for Fas ligand in the cell-cycle arrest of CD4+ T cells

1998 • 109 citations

Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes

1999 • 98 citations

Biologically Active Fas Antigen and Its Cognate Ligand Are Expressed on Plasma Membrane-Derived Extracellular Vesicles

1998 • 98 citations

Engagement of CD153 (CD30 Ligand) by CD30+ T Cells Inhibits Class Switch DNA Recombination and Antibody Production in Human IgD+ IgM+ B Cells

2000 • 97 citations

Enhanced Secretion of IFN-γ by Activated Th1 Cells Occurs Via Reverse Signaling Through TNF-Related Activation-Induced Cytokine

2001 • 95 citations

CD137 Induces Proliferation and Endomitosis in Monocytes

1999 • 93 citations

Regulation of activation-induced cell death of mature T-lymphocyte populations

2000 • 87 citations

Technical Note: Aberrant Detection of Cell Surface Fas Ligand with Anti-Peptide Antibodies

1998 • 84 citations

Separate Domains of the Human Fas Ligand Dictate Self-association and Receptor Binding

1997 • 82 citations

Adapters in lymphocyte signalling

2001 • 82 citations

Functional modules and expression of mouse p40 ^phox and p67^phox, SH3‐domain‐containing proteins involved in the phagocyte NADPH oxidase complex

1998 • 77 citations

The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins

1998 • 68 citations

Interaction of peptides derived from the Fas ligand with the Fyn‐SH3 domain

1995 • 60 citations

SLP-76 Binding to p56lck: A Role for SLP-76 in CD4-Induced Desensitization of the TCR/CD3 Signaling Complex

1999 • 55 citations

The role of adapter proteins in T cell activation

1999 • 25 citations

Differential Regulation of Activation-Induced Cell Death in Individual Human T Cell Clones

2000 • 24 citations

Sorting out the multiple roles of Fas ligand

2000 • 22 citations