SLP-76 Binding to p56lck: A Role for SLP-76 in CD4-Induced Desensitization of the TCR/CD3 Signaling Complex

The Fas Death Factor

1995 • 4,070 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Structural basis for the binding of proline-rich peptides to SH3 domains

1994 • 1,016 citations

Fas ligand mediates activation-induced cell death in human T lymphocytes.

1995 • 949 citations

Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals.

1992 • 907 citations

Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions

1994 • 800 citations

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

1992 • 689 citations

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

1990 • 526 citations

Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains

1994 • 519 citations

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.

1989 • 514 citations

BLNK

1998 • 501 citations

Phosphorylation of SLP-76 by the ZAP-70 Protein-tyrosine Kinase Is Required for T-cell Receptor Function

1996 • 460 citations

Uncoupling of Nonreceptor Tyrosine Kinases from PLC-γ1 in an SLP-76-Deficient T Cell

1998 • 412 citations

An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis

1994 • 407 citations

Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development

1998 • 405 citations

Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen

1990 • 375 citations

A target for Src in mitosis

1994 • 361 citations

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

1992 • 361 citations

Impaired Viability and Profound Block in Thymocyte Development in Mice Lacking the Adaptor Protein SLP-76

1998 • 360 citations

Molecular Cloning of SLP-76, a 76-kDa Tyrosine Phosphoprotein Associated with Grb2 in T Cells

1995 • 337 citations

Vav and SLP-76 Interact and Functionally Cooperate in IL-2 Gene Activation

1996 • 335 citations

Perturbation of the T4 molecule transmits a negative signal to T cells.

1985 • 335 citations

Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates

1992 • 306 citations

Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression.

1994 • 274 citations

DIFFERENTIAL SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS

1997 • 273 citations

SLP-65: A New Signaling Component in B Lymphocytes which Requires Expression of the Antigen Receptor for Phosphorylation

1998 • 271 citations

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

1997 • 265 citations

Interleukin 16 and its function as a CD4 ligand

1996 • 261 citations

Receptor-stimulated death pathway is opened by antigen in mature T cells.

1991 • 255 citations

Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals

1993 • 242 citations

Molecular Cloning of SLAP-130, an SLP-76-associated Substrate of the T Cell Antigen Receptor-stimulated Protein Tyrosine Kinases

1997 • 238 citations

The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.

1991 • 234 citations

Regulation of Vav–SLP-76 Binding by ZAP-70 and Its Relevance to TCRζ/CD3 Induction of Interleukin-2

1997 • 224 citations

CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response.

1996 • 198 citations

p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells.

1996 • 194 citations

Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production.

1996 • 194 citations

The SH3 Domain-binding T Cell Tyrosyl Phosphoprotein p120

1995 • 186 citations

Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.

1993 • 178 citations

Two-step TCRζ/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyrosine and lipid kinases

1994 • 176 citations

T cell receptor/CD3-signaling induces death by apoptosis in human T cell receptor gamma delta + T cells.

1991 • 167 citations

Signal transduction through cd4 receptors: stimulatory vs. inhibitory activity is regulated by cd4 proximity to the cd31t cell receptor

1988 • 166 citations

Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase.

1993 • 142 citations

Cross-linking of T3 (CD3) with T4 (CD4) enhances the proliferation of resting T lymphocytes.

1987 • 136 citations

IL-16 inhibition of CD3-dependent lymphocyte activation and proliferation.

1996 • 135 citations

Synergism Between HIV gp120 and gp120-Specific Antibody in Blocking Human T Cell Activation

1989 • 135 citations

Inhibition of T Cell Receptor Expression and Function in Immature CD4 ⁺ cD8 ⁺ Cells by CD4

1990 • 129 citations

Human CD4+ cells transfected with IL-16 cDNA are resistant to HIV-1 infection: Inhibition of mRNA expression

1997 • 123 citations

Views on Vav

1997 • 103 citations

CD4 engagement induces Fas antigen‐dependent apoptosis of T cells in vivo

1994 • 98 citations

Solution structure and peptide binding of the SH3 domain from human Fyn

1996 • 95 citations

Differential Regulation of Activation-induced Tyrosine Phosphorylation and Recruitment of SLP-76 to Vav by Distinct Isoforms of the CD45 Protein-tyrosine Phosphatase

1996 • 95 citations

CD4 Regulates Susceptibility to Fas ligand– and Tumor Necrosis Factor–mediated Apoptosis

1998 • 89 citations

Three domains of SLP-76 are required for its optimal function in a T cell line.

1997 • 87 citations

SLP-76 Expression Is Restricted to Hemopoietic Cells of Monocyte, Granulocyte, and T Lymphocyte Lineage and Is Regulated During T Cell Maturation and Activation

1998 • 75 citations

The Human p62 cDNA Encodes Sam68 and Not the RasGAP-Associated p62 Protein

1996 • 74 citations

Control of memory CD4 T cell activation: MHC class II molecules on APCs and CD4 ligation inhibit memory but not naive CD4 T cells

1995 • 72 citations

The role of Grb2-associated proteins in T-cell activation

1997 • 68 citations

Lck is necessary and sufficient for Fas-ligand expression and apoptotic cell death in mature cycling T cells.

1997 • 68 citations

Life and death of a superantigen-reactive human CD4⁺ T cell clone: staphylococcal enterotoxins induce death by apoptosis but simultaneously trigger a proliferative response in the presence of HLA-DR⁺ antigen-presenting cells

1992 • 63 citations

CD4 ligands inhibit the formation of multifunctional transduction complexes involved in T cell activation.

1997 • 61 citations

Peripheral T lymphocyte depletion by apoptosis after CD4 ligationin vivo: selective loss of CD44− and ‘activating’ memory T cells

1994 • 58 citations

Prevention of anti-CD3 monoclonal antibody-induced thymic apoptosis by protein tyrosine kinase inhibitors.

1994 • 57 citations

Fas (CD95) expression and death-mediating function are induced by CD4 cross-linking on CD4+ T cells.

1996 • 56 citations

Distinct signaling properties identify functionally different CD4 epitopes

1995 • 53 citations

HIV-1 gp120 and anti-gp120 induce reversible unresponsiveness in peripheral CD4 T lymphocytes.

1994 • 52 citations

HIV-induced apoptosis requires the CD4 receptor cytoplasmic tail and is accelerated by interaction of CD4 with p56lck.

1996 • 50 citations

p56lck plays a key role in transducing apoptotic signals in T cells

1995 • 49 citations

Requirement of P56lck in T-Cell Receptor CD3-Mediated Apoptosis and Fas-Ligand Induction Jurkat Cells

1995 • 49 citations

Sequestration of p56(lck) by gp120, a model for TCR desensitization.

1997 • 46 citations

Recombinant human IL-16 inhibits HIV-1 replication and protects against activation-induced cell death (AICD)

1998 • 42 citations

Chimaeric anti‐CD4 monoclonal antibody cross‐linked by monocyte Fcγ receptor mediates apoptosis of human CD4 lymphocytes

1993 • 36 citations

Extensive CD4 cross-linking inhibits T cell activation by anti-receptor antibody but not by antigen

1992 • 27 citations

Ligation of cell surface CD4 inhibits activation-induced death of human T lymphocytes at the level of Fas ligand expression.

1997 • 27 citations

Phosphatidylinositol (PI) 3-Kinase and PI 4-Kinase Binding to the CD4-p56^lck Complex: the p56^lck SH3 Domain Binds to PI 3-Kinase but Not PI 4-Kinase

1993 • 27 citations

HIV envelope-directed signaling aberrancies and cell death of CD4⁺ T cells in the absence of TCR co-stimulation

1996 • 24 citations

Determination of the solution structure of the SH3 domain of human p56 Lck tyrosine kinase

1996 • 24 citations

Costimulatory Properties of the Human CD4 Molecule: Enhancement of CD3-Induced T Cell Activation by Human Immunodeficiency Virus Type 1 through Viral Envelope Glycoprotein gp120

1993 • 18 citations

Differential role of tyrosine phosphorylation in the induction of apoptosis in T cell clones via CD95 or the TCR/CD3-complex

1997 • 9 citations

Deleted Work

1955 • 0 citations