Cell-death signaling and human disease

The Fas Death Factor

1995 • 4,070 citations

The TNF and TNF Receptor Superfamilies

2001 • 3,533 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity

1995 • 1,306 citations

Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

1998 • 1,224 citations

Fas and Fas ligand: lpr and gld mutations

1995 • 906 citations

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

2002 • 685 citations

Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations

2000 • 650 citations

Inherited Human Caspase 10 Mutations Underlie Defective Lymphocyte and Dendritic Cell Apoptosis in Autoimmune Lymphoproliferative Syndrome Type II

1999 • 631 citations

Death Receptor Recruitment of Endogenous Caspase-10 and Apoptosis Initiation in the Absence of Caspase-8

2001 • 521 citations

FasGene Mutations in the Canale–Smith Syndrome, an Inherited Lymphoproliferative Disorder Associated with Autoimmunity

1996 • 486 citations

Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease.

1996 • 473 citations

The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis

2001 • 454 citations

The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity

2000 • 440 citations

Molecular Ordering of the Initial Signaling Events of CD95

2002 • 387 citations

Caspase-10 is an initiator caspase in death receptor signaling

2001 • 387 citations

Regulation of lymphocyte proliferation and death by flip

2001 • 385 citations

Clinical, Immunologic, and Genetic Features of an Autoimmune Lymphoproliferative Syndrome Associated With Abnormal Lymphocyte Apoptosis

1997 • 374 citations

Somatic Fas Mutations in Non-Hodgkin’s Lymphoma: Association With Extranodal Disease and Autoimmunity

1998 • 324 citations

Pathological Findings in Human Autoimmune Lymphoproliferative Syndrome

1998 • 223 citations

Autoimmune Lymphoproliferative Syndrome with Defective Fas: Genotype Influences Penetrance

1999 • 210 citations

Clinical, immunological, and pathological consequences of Fas-deficient conditions

1996 • 184 citations

Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia

1999 • 179 citations

Missense mutations in the Fas gene resulting in autoimmune lymphoproliferative syndrome: a molecular and immunological analysis.

1997 • 177 citations

Missense Mutations in the Fas Gene Resulting in Autoimmune Lymphoproliferative Syndrome: A Molecular and Immunological Analysis

1997 • 168 citations

Chronic lymphadenopathy simulating malignant lymphoma

1966 • 159 citations

The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo-1) mutations

1999 • 156 citations

Lymphoproliferative syndrome with autoimmunity: A possible genetic basis for dominant expression of the clinical manifestations.

1999 • 148 citations

Immunophenotypic profiles in families with autoimmune lymphoproliferative syndrome

2001 • 142 citations

Mutation of CD95 (Fas/Apo-1) Gene in Adult T-Cell Leukemia Cells

1998 • 130 citations

CD95 (APO-1/Fas) Mutations in Childhood T-Lineage Acute Lymphoblastic Leukemia

1998 • 121 citations

The clinical spectrum in a large kindred with autoimmune lymphoproliferative syndrome caused by a Fas mutation that impairs lymphocyte apoptosis

1998 • 112 citations

Increases in circulating and lymphoid tissue interleukin-10 in autoimmune lymphoproliferative syndrome are associated with disease expression

2001 • 112 citations

Novel Fas (CD95/APO-1) mutations in infants with a lymphoproliferative disorder.

1998 • 99 citations

Fas/Apo1 mutations and autoimmune lymphoproliferative syndrome in a patient with type 2 autoimmune hepatitis

1997 • 62 citations

Autoimmune Lymphoproliferative Syndrome (ALPS) in a Child from Consanguineous Parents: A Dominant or Recessive Disease?

2000 • 61 citations

Response to steroid therapy in autism secondary to autoimmune lymphoproliferative syndrome

2000 • 60 citations

Correction of Fas (CD95) deficiency by haploidentical bone marrow transplantation

1997 • 57 citations

Defective Function of Fas in Patients With Type 1 Diabetes Associated With Other Autoimmune Diseases

2001 • 52 citations

Activation and Differentiation of Autoreactive B-1 Cells by Interleukin 10 Induce Autoimmune Hemolytic Anemia in Fas-deficient Antierythrocyte Immunoglobulin Transgenic Mice

2002 • 43 citations

The V410I (G1228A) variant of the caspase-10 gene is a common polymorphism in the Danish population

2000 • 40 citations

Identification of New Fas Mutations in a Patient with Autoimmune Lymphoproliferative Syndrome (ALPS) and Eosinophilia

1999 • 35 citations

Dyserythropoiesis associated with a Fas‐deficient condition in childhood

2000 • 35 citations

Autoimmune Lymphoproliferative Syndrome: A Syndrome Associated with Inherited Genetic Defects That Impair Lymphocytic Apoptosis—CT and US Features

1999 • 32 citations

Increased spontaneous in vitro apoptosis in double negative T cells of humans with a fas/apo-1 mutation

1998 • 27 citations

Diffuse large B‐cell non‐Hodgkin's lymphoma in a patient with autoimmune lymphoproliferative syndrome

2001 • 20 citations

Cytomegalovirus infection in infants with autoimmune lymphoproliferative syndrome (ALPS)

2000 • 17 citations

Characterization of lymphoproliferation induced by interactions between Ipr and gld genes

1991 • 9 citations

Molecular Genetic Studies in Lymphocyte Apoptosis and Human Autoimmunity

2007 • 8 citations