Regulatory T Cells in Radiotherapeutic Responses

Dendritic cells and the control of immunity

1998 • 14,345 citations

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

2010 • 14,016 citations

Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

2006 • 5,923 citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

The Danger Model: A Renewed Sense of Self

2002 • 4,107 citations

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

Cancer immunotherapy comes of age

2011 • 3,453 citations

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

2011 • 3,323 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

Tolerogenic Dendritic Cells

2003 • 3,131 citations

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

2002 • 2,879 citations

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

2007 • 2,814 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

2007 • 2,215 citations

Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma

2012 • 1,925 citations

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

2009 • 1,688 citations

Molecular identification of a danger signal that alerts the immune system to dying cells

2003 • 1,649 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

2003 • 1,564 citations

Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis

2003 • 1,538 citations

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

2006 • 1,499 citations

Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti–CTLA-4 Antibody

2009 • 1,480 citations

Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma

2002 • 1,454 citations

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

2008 • 1,436 citations

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

2011 • 1,386 citations

Natural versus adaptive regulatory T cells

2003 • 1,363 citations

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

2010 • 1,278 citations

Cancer despite immunosurveillance: immunoselection and immunosubversion

2006 • 1,263 citations

Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment

2009 • 1,232 citations

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

2011 • 1,191 citations

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

2007 • 1,181 citations

Intracellular pattern recognition receptors in the host response

2006 • 1,170 citations

5-Fluorouracil Selectively Kills Tumor-Associated Myeloid-Derived Suppressor Cells Resulting in Enhanced T Cell–Dependent Antitumor Immunity

2010 • 1,119 citations

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

2009 • 1,026 citations

Mechanisms of suppression by suppressor T cells

2005 • 1,023 citations

Immune infiltration in human tumors: a prognostic factor that should not be ignored

2009 • 1,020 citations

Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

2005 • 998 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

Immune-Mediated Inhibition of Metastases after Treatment with Local Radiation and CTLA-4 Blockade in a Mouse Model of Breast Cancer

2005 • 940 citations

Systemic effects of local radiotherapy

2009 • 906 citations

Local Radiation Therapy of B16 Melanoma Tumors Increases the Generation of Tumor Antigen-Specific Effector Cells That Traffic to the Tumor

2005 • 894 citations

Infectious immunological tolerance.

1971 • 811 citations

TLRs and innate immunity

2008 • 800 citations

The Efficacy of Radiotherapy Relies upon Induction of Type I Interferon–Dependent Innate and Adaptive Immunity

2011 • 773 citations

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signalsin vivo

2004 • 761 citations

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

2012 • 759 citations

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice

2010 • 729 citations

In Vivo Instruction of Suppressor Commitment in Naive T Cells

2004 • 726 citations

Cutting Edge: Regulatory T Cells Induce CD4+CD25−Foxp3− T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-β

2007 • 704 citations

Ipilimumab (Anti-CTLA4 Antibody) Causes Regression of Metastatic Renal Cell Cancer Associated With Enteritis and Hypophysitis

2007 • 673 citations

Radiation-Induced CXCL16 Release by Breast Cancer Cells Attracts Effector T Cells

2008 • 650 citations

Adenosine, an endogenous anti-inflammatory agent

1994 • 635 citations

TGF-β1 and radiation fibrosis: a master switch and a specific therapeutic target?

2000 • 626 citations

The grateful dead: damage‐associated molecular pattern molecules and reduction/oxidation regulate immunity

2007 • 616 citations

Cancer Immunotherapy Comes of Age

2011 • 560 citations

A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Comparing the Tolerability and Efficacy of Ipilimumab Administered with or without Prophylactic Budesonide in Patients with Unresectable Stage III or IV Melanoma

2009 • 551 citations

Peripheral CD4⁺ T‐cell differentiation regulated by networks of cytokines and transcription factors

2010 • 535 citations

Sublethal Irradiation of Human Tumor Cells Modulates Phenotype Resulting in Enhanced Killing by Cytotoxic T Lymphocytes

2004 • 532 citations

Myeloid C-type lectins in innate immunity

2006 • 505 citations

Maximizing Tumor Immunity With Fractionated Radiation

2011 • 503 citations

Oral tolerance in the absence of naturally occurring Tregs

2005 • 474 citations

A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells

2007 • 468 citations

Irradiation of Tumor Cells Up-Regulates Fas and Enhances CTL Lytic Activity and CTL Adoptive Immunotherapy

2003 • 452 citations

Radiation-Induced IFN-γ Production within the Tumor Microenvironment Influences Antitumor Immunity

2008 • 436 citations

Tumor-infiltrating dendritic cell precursors recruited by a β-defensin contribute to vasculogenesis under the influence of Vegf-A

2004 • 430 citations

External Beam Radiation of Tumors Alters Phenotype of Tumor Cells to Render Them Susceptible to Vaccine-Mediated T-Cell Killing

2004 • 425 citations

The Prognostic Value of FoxP3+ Tumor-Infiltrating Lymphocytes in Cancer: A Critical Review of the Literature

2012 • 417 citations

CD4+CD25high T Cells Are Enriched in the Tumor and Peripheral Blood of Prostate Cancer Patients

2006 • 416 citations

A Requisite Role for Induced Regulatory T Cells in Tolerance Based on Expanding Antigen Receptor Diversity

2011 • 404 citations

Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells.

1988 • 389 citations

CD25− T Cells Generate CD25+Foxp3+ Regulatory T Cells by Peripheral Expansion

2004 • 373 citations

Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects?

2001 • 371 citations

Radiation Enhances Regulatory T Cell Representation

2010 • 368 citations

The Abscopal Effect Associated With a Systemic Anti-melanoma Immune Response

2013 • 362 citations

Cytokines in Radiobiological Responses: A Review

2012 • 359 citations

Classical and alternative activation of mononuclear phagocytes: Picking the best of both worlds for tumor promotion

2006 • 359 citations

Cutting Edge: Foxp3+CD4+CD25+ Regulatory T Cells Induced by IL-2 and TGF-β Are Resistant to Th17 Conversion by IL-6

2008 • 347 citations

HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression

2009 • 333 citations

Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment

2010 • 329 citations

A Sense of Danger from Radiation¹

2004 • 317 citations

Prognostic role of FOXP3+ regulatory T cells infiltrating human carcinomas: the paradox of colorectal cancer

2011 • 307 citations

Targeting cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4)

2007 • 304 citations

Cancer Cells Expressing Toll-like Receptors and the Tumor Microenvironment

2009 • 303 citations

TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells

2012 • 263 citations

Response to self antigen imprints regulatory memory in tissues

2011 • 257 citations

Immune Response During Therapy With Cisplatin or Radiation for Human Papillomavirus–Related Head and Neck Cancer

2009 • 237 citations

Th17 Response and Inflammatory Autoimmune Diseases

2011 • 221 citations

Regulatory T-Cells: Diverse Phenotypes Integral to Immune Homeostasis and Suppression

2012 • 218 citations

A Central Role for Induced Regulatory T Cells in Tolerance Induction in Experimental Colitis

2009 • 217 citations

Genomic definition of multiple ex vivo regulatory T cell subphenotypes

2010 • 208 citations

Targeting Regulatory T Cells in Cancer

2011 • 186 citations

Irradiation Promotes an M2 Macrophage Phenotype in Tumor Hypoxia

2012 • 178 citations

T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response

2009 • 178 citations

Standard Treatments Induce Antigen-Specific Immune Responses in Prostate Cancer

2007 • 167 citations

Increased Ectonucleotidase Expression and Activity in Regulatory T Cells of Patients with Head and Neck Cancer

2009 • 166 citations

Transient T cell depletion causes regression of melanoma metastases

2008 • 153 citations

Cyclophosphamide-induced immunologically mediated regression of a cyclophosphamide-resistant murine tumor: a consequence of eliminating precursor L3T4+ suppressor T-cells.

1989 • 149 citations

T-Cell Responses to Survivin in Cancer Patients Undergoing Radiation Therapy

2008 • 140 citations

Cyclophosphamide-based metronomic chemotherapy: After 10 years of experience, where do we stand and where are we going?

2011 • 127 citations

Radiotherapy Decreases Vascular Density and Causes Hypoxia with Macrophage Aggregation in TRAMP-C1 Prostate Tumors

2009 • 121 citations

Gamma-Ray Resistance of Regulatory CD4⁺CD25⁺Foxp3⁺T Cells in Mice

2009 • 119 citations

Regression and inhibition of sarcoma growth by interference with a radiosensitive T-cell population.

1978 • 118 citations

Regulatory/suppressor T cells in health and disease

2004 • 112 citations

Links between Innate Immunity and Normal Tissue Radiobiology

2010 • 110 citations

Impact of localized radiotherapy on blood immune cells counts and function in humans

1999 • 108 citations

Natural but Not Inducible Regulatory T Cells Require TNF-α Signaling for In Vivo Function

2011 • 107 citations

Hyper Immunoglobulin E Response in Mice with Monoclonal Populations of B and T Lymphocytes✪

2001 • 104 citations

Radiation-induced, immunologically mediated regression of an established tumor as an example of successful therapeutic immunomanipulation. Preferential elimination of suppressor T cells allows sustained production of effector T cells.

1986 • 102 citations

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

2006 • 101 citations

Ionizing radiation and autoimmunity. Induction of autoimmune disease in mice by high dose fractionated total lymphoid irradiation and its prevention by inoculating normal T cells.

1994 • 101 citations

Ncf1 (p47phox) Is Essential for Direct Regulatory T Cell Mediated Suppression of CD4+ Effector T Cells

2011 • 98 citations

Angiogenesis and the Tumor Vasculature as Antitumor Immune Modulators: The Role of Vascular Endothelial Growth Factor and Endothelin

2010 • 94 citations

FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells

2011 • 91 citations

Tumor stress, cell death and the ensuing immune response

2007 • 86 citations

Radiation induces an antitumour immune response to mouse melanoma

2009 • 75 citations

Oxidative Lipidomics of γ-Radiation-Induced Lung Injury: Mass Spectrometric Characterization of Cardiolipin and Phosphatidylserine Peroxidation

2011 • 75 citations

Radiation therapy and Toll-like receptor signaling: implications for the treatment of cancer

2008 • 73 citations

TGF-β induces the expression of the adaptor Ndfip1 to silence IL-4 production during iTreg cell differentiation

2011 • 71 citations

Increased CD8+ T-cell Function following Castration and Immunization Is Countered by Parallel Expansion of Regulatory T Cells

2012 • 69 citations

Repeated Gamma Irradiation Attenuates Collagen-Induced Arthritis via Up-regulation of Regulatory T Cells but not by Damaging Lymphocytes Directly

2010 • 69 citations

The Plasticity of Regulatory T Cell Function

2011 • 69 citations

Gamma irradiation alters the phenotype and function of CD4⁺CD25⁺ regulatory T cells

2009 • 57 citations

Heterogeneity in tumor microvascular response to radiation

1990 • 57 citations

T-Cell Immunosenescence and Inflammatory Response in Atomic Bomb Survivors

2010 • 56 citations

CD4⁺ CD25⁺ Treg: divide and rule?

2004 • 56 citations

Combining radiation and immunotherapy for synergistic antitumor therapy.

2009 • 55 citations

Tricks tumors use to escape from immune control

2009 • 53 citations

Reduced tumor growth after low-dose irradiation or immunization against blastic suppressor T cells.

1981 • 52 citations

Abdominal γ-Radiation Induces an Accumulation of Function-Impaired Regulatory T Cells in the Small Intestine

2011 • 51 citations

Elevation of Extracellular Adenosine Induces Radioprotective Effects in Mice

1993 • 48 citations

Molecular responses of rectal cancer to preoperative chemoradiation

2006 • 43 citations

Identification of Circulating Human Antigen-Reactive CD4+FOXP3+ Natural Regulatory T Cells

2011 • 42 citations

Diverse Functional Activity of CD83+ Monocyte-Derived Dendritic Cells and the Implications for Cancer Vaccines

2001 • 42 citations

Double blind randomized phase II study with radiation+5-fluorouracil±celecoxib for resectable rectal cancer

2009 • 42 citations

The therapeutic activity of low-dose irradiation on experimental arthritis depends on the induction of endogenous regulatory T cell activity

2010 • 40 citations

Molecular mechanisms underlying the regulation and functional plasticity of FOXP3+ regulatory T cells

2011 • 40 citations

Effects of Irradiation on the Expression of Surface Antigens in Human Ovarian Cancer

1996 • 36 citations

γ-Ray irradiation induces B7.1 costimulatory molecule neoexpression in various murine tumor cells

1998 • 34 citations

Induction of tolerance to a murine fibrosarcoma in two zones of dosage – the involvement of suppressor cells

1986 • 34 citations

Tumor‐specific T helper activity can be abrogated by two distinct suppressor cell mechanisms

1982 • 33 citations

Regulatory T Cells: Key Players in Tolerance and Autoimmunity

2009 • 32 citations

Enhancement of B7‐1 (CD80) expression on B‐lymphoma cells by irradiation

1999 • 32 citations

Granulocyte colony‐stimulating factor and drugs elevating extracellular adenosine synergize to enhance haematopoietic reconstitution in irradiated mice

1998 • 30 citations

Drugs elevating extracellular adenosine promote regeneration of haematopoietic progenitor cells in severely myelosuppressed mice: their comparison and joint effects with the granulocyte colony‐stimulating factor

2002 • 28 citations

Protective Effects of Inosine on Mice Subjected to Lethal Total-body Ionizing Irradiation

2007 • 21 citations

Protection of early cellular damage in 1 Gy-irradiated mice by the elevation of extracellular adenosine

1992 • 20 citations

Cyclophosphamide-sensitive and cyclophosphamide-resistant suppressor cells in the immune response to alloantigens.

1979 • 6 citations

Gamma irradiation alters the phenotype and function of CD4+CD25+ regulatory T cells (88.2)

2007 • 5 citations

Transient T-cell depletion causes regression of melanoma metastases

2008 • 4 citations