Regulatory T-Cells: Diverse Phenotypes Integral to Immune Homeostasis and Suppression

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Regulatory T Cells and Immune Tolerance

2008 • 4,778 citations

IL-17 and Th17 Cells

2009 • 4,491 citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

How regulatory T cells work

2008 • 3,048 citations

Transforming growth factor-β induces development of the TH17 lineage

2006 • 3,014 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

2007 • 2,215 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

2007 • 1,808 citations

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

2008 • 1,759 citations

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

2002 • 1,733 citations

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

2009 • 1,688 citations

Autoimmunity to type II collagen an experimental model of arthritis.

1977 • 1,599 citations

Regulatory T cells mediate maternal tolerance to the fetus

2004 • 1,568 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties

2006 • 1,403 citations

CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells

2007 • 1,161 citations

Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans

2006 • 1,156 citations

A Regulatory B Cell Subset with a Unique CD1dhiCD5+ Phenotype Controls T Cell-Dependent Inflammatory Responses

2008 • 1,154 citations

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1994 • 1,129 citations

The infusion of ex vivo activated and expanded CD4+CD25+ immune regulatory cells inhibits graft-versus-host disease lethality

2002 • 1,061 citations

Natural regulatory T cells in infectious disease

2005 • 1,035 citations

Mechanisms of suppression by suppressor T cells

2005 • 1,023 citations

Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide

2003 • 976 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

Infectious immunological tolerance.

1971 • 811 citations

Tolerization of dendritic cells by TS cells: the crucial role of inhibitory receptors ILT3 and ILT4

2002 • 800 citations

Oral tolerance: immune mechanisms and treatment of autoimmune diseases

1997 • 757 citations

Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases

2004 • 727 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 709 citations

Rapamycin Promotes Expansion of Functional CD4+CD25+FOXP3+ Regulatory T Cells of Both Healthy Subjects and Type 1 Diabetic Patients

2006 • 693 citations

CD40/CD154 Interactions at the Interface of Tolerance and Immunity

2004 • 673 citations

CELL TO CELL INTERACTION IN THE IMMUNE RESPONSE

1968 • 668 citations

Experimental Autoimmune Encephalomyelitis Induction in Genetically B Cell–deficient Mice

1996 • 665 citations

CELL TO CELL INTERACTION IN THE IMMUNE RESPONSE

1968 • 639 citations

Regulatory T Cells Induced by 1α,25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance

2001 • 627 citations

Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3

2008 • 621 citations

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells

2009 • 621 citations

Thymus-Marrow Cell Combinations. Synergism in Antibody Production.

1966 • 613 citations

A Requirement for Two Cell Types for Antibody Formation in vitro

1967 • 612 citations

Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level

2005 • 589 citations

An immunomodulatory role for CD4+CD25+ regulatory T lymphocytes in hepatitis C virus infection

2004 • 558 citations

Mother's little helpers: mechanisms of maternal-fetal tolerance

2006 • 557 citations

Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells

2004 • 519 citations

Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans

2007 • 516 citations

Probiotics Ameliorate Recurrent Th1-Mediated Murine Colitis by Inducing IL-10 and IL-10-Dependent TGF-β-Bearing Regulatory Cells

2005 • 507 citations

Interactions Between the Host Innate Immune System and Microbes in Inflammatory Bowel Disease

2011 • 496 citations

Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells

2006 • 493 citations

B Cells and Antibody Play Critical Roles in the Immediate Defense of Disseminated Infection by West Nile Encephalitis Virus

2003 • 473 citations

Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment?

2009 • 471 citations

Human CD4⁺CD25⁺Regulatory T Cells Control T-Cell Responses to Human Immunodeficiency Virus and Cytomegalovirus Antigens

2004 • 436 citations

Human T Regulatory Cell Therapy: Take a Billion or So and Call Me in the Morning

2009 • 411 citations

Lipopolysaccharide-Activated B Cells Down-Regulate Th1 Immunity and Prevent Autoimmune Diabetes in Nonobese Diabetic Mice

2001 • 392 citations

The Pathogenesis of Schistosomiasis Is Controlled by Cooperating IL-10-Producing Innate Effector and Regulatory T Cells

2004 • 367 citations

CD4+CD25+ Regulatory T Cells Control the Severity of Viral Immunoinflammatory Lesions

2004 • 357 citations

Evidence for a Selective Migration of Fetus-Specific CD4+CD25bright Regulatory T Cells from the Peripheral Blood to the Decidua in Human Pregnancy

2008 • 356 citations

‘Yin–Yang’ functions of transforming growth factor‐β and T regulatory cells in immune regulation

2007 • 356 citations

Role of CD8 ⁺ T Cells in Murine Experimental Allergic Encephalomyelitis

1992 • 351 citations

X-linked lymphoreticular disease in the scurfy (sf) mutant mouse.

1991 • 339 citations

Phenotypic characterization of regulatory T cells in the human decidua

2004 • 338 citations

Cutting Edge: The Prevalence of Regulatory T Cells in Lymphoid Tissue Is Correlated with Viral Load in HIV-Infected Patients

2005 • 337 citations

Neuropilin-1 Expression on Regulatory T Cells Enhances Their Interactions with Dendritic Cells during Antigen Recognition

2008 • 333 citations

Seminal Fluid Drives Expansion of the CD4+CD25+ T Regulatory Cell Pool and Induces Tolerance to Paternal Alloantigens in Mice1

2009 • 328 citations

Bacteria-triggered CD4+ T Regulatory Cells Suppress Helicobacter hepaticus–induced Colitis

2002 • 324 citations

HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4⁺T cells

2004 • 314 citations

Bone Marrow NK1.1− and NK1.1+ T Cells Reciprocally Regulate Acute Graft versus Host Disease

1999 • 312 citations

Helicobacter pylori - Specific CD4 ⁺ CD25 ^high Regulatory T Cells Suppress Memory T-Cell Responses to H . pylori in Infected Individuals

2003 • 310 citations

HIV Infection of Naturally Occurring and Genetically Reprogrammed Human Regulatory T-cells

2004 • 308 citations

Negative Regulation of T Cell Homeostasis by Lymphocyte Activation Gene-3 (CD223)

2005 • 306 citations

Naturally anergic and suppressive CD25+CD4+ T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation

2000 • 294 citations

CD25⁺CD4⁺regulatory T cells suppress CD4⁺T cell‐mediated pulmonary hyperinflammation driven byPneumocystis cariniiin immunodeficient mice

2002 • 276 citations

Interleukin-23/Th17 pathways and inflammatory bowel disease

2009 • 276 citations

Effector and Regulatory T-cell Subsets in Autoimmunity and Tissue Inflammation

2010 • 265 citations

Translational Mini-Review Series on Th17 Cells: Function and regulation of human T helper 17 cells in health and disease

2009 • 263 citations

Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo

2005 • 250 citations

How do CD4+CD25+ regulatory T cells control autoimmunity?

2005 • 249 citations

CD25+CD4+ regulatory T cells suppress CD4+ T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice

2002 • 245 citations

Regulatory T Cells

2005 • 242 citations

T lymphocytes from healthy individuals with specificity to self-epitopes shared by the mycobacterial and human 65-kilodalton heat shock protein.

1989 • 237 citations

B7/CD28-Dependent CD4+CD25+ Regulatory T Cells Are Essential Components of the Memory-Protective Immunity to Candida albicans

2002 • 236 citations

Natural regulatory T cells and self-tolerance

2005 • 234 citations

Qa-1 restricted recognition of foreign antigen by a γδ T-cell hybridoma

1989 • 233 citations

Differentiation of regulatory Foxp3⁺T cells in the thymic cortex

2008 • 227 citations

Gamma delta T lymphocytes regulate the induction and maintenance of oral tolerance.

1997 • 227 citations

TLR-9 Activation of Marginal Zone B Cells in Lupus Mice Regulates Immunity Through Increased IL-10 Production

2005 • 225 citations

Naturally Occurring Lung CD4+CD25+ T Cell Regulation of Airway Allergic Responses Depends on IL-10 Induction of TGF-β

2007 • 221 citations

Regulatory CD4+CD25+ T Cells Restrict Memory CD8+ T Cell Responses

2002 • 209 citations

Ly and Ia antigen phenotypes of T cells involved in delayed-type hypersensitivity and in suppression.

1976 • 208 citations

Regulatory role of mature B cells in a murine model of inflammatory bowel disease

2000 • 202 citations

Cellular and molecular characterization of the scurfy mouse mutant.

1999 • 197 citations

Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients

2007 • 195 citations

CD8⁺CD28⁻ T suppressor cells and the induction of antigen‐specific, antigen‐presenting cell‐mediated suppression of Th reactivity

2001 • 185 citations

Th17 and regulatory T cells: rebalancing pro- and anti-inflammatory forces in autoimmune arthritis

2009 • 183 citations

Thymic regulatory T cells

2005 • 181 citations

The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade

2003 • 180 citations

Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+CD25+ regulatory T cells in the regional lymph node

2005 • 180 citations

Mechanisms of T regulatory cell function

2008 • 176 citations

Critical appraisal of the current practice in murine TNBS-induced colitis

2006 • 176 citations

Properties and origin of human Th17 cells

2009 • 176 citations

Development and activation of regulatory T cells in the human fetus

2005 • 167 citations

Fetal alloantigen is responsible for the expansion of the CD4+CD25+ regulatory T cell pool during pregnancy

2007 • 164 citations

Foxp3+ regulatory T cells in the control of experimental CNS autoimmune disease

2008 • 163 citations

microRNA-342, microRNA-191 and microRNA-510 are differentially expressed in T regulatory cells of type 1 diabetic patients

2009 • 163 citations

Regulation of Trafficking Receptor Expression in Human Forkhead Box P3+ Regulatory T Cells

2006 • 161 citations

The Family of IL-10-Secreting CD4+ T Cells

2010 • 161 citations

Cellular and Molecular Characterization of thescurfyMouse Mutant

1999 • 160 citations

The role of semen in induction of maternal immune tolerance to pregnancy

2001 • 157 citations

Mouse CD1-Autoreactive T Cells Have Diverse Patterns of Reactivity to CD1+ Targets

1998 • 152 citations

CD4+ Vα14 natural killer T cells are essential for acceptance of rat islet xenografts in mice

2000 • 147 citations

T regulatory cells and their counterparts: masters of immune regulation

2009 • 147 citations

Depletion of IL-10- and TGF-beta-producing regulatory gamma delta T cells by administering a daunomycin-conjugated specific monoclonal antibody in early tumor lesions augments the activity of CTLs and NK cells.

1999 • 144 citations

CD4+CD25+Foxp3+ Regulatory T Cells Depletion May Attenuate the Development of Silica-Induced Lung Fibrosis in Mice

2010 • 124 citations

CD4+ NKT Cells, But Not Conventional CD4+ T Cells, Are Required to Generate Efferent CD8+ T Regulatory Cells Following Antigen Inoculation in an Immune-Privileged Site

2003 • 124 citations

Depletion of IL-10- and TGF-β-Producing Regulatory γδ T Cells by Administering a Daunomycin-Conjugated Specific Monoclonal Antibody in Early Tumor Lesions Augments the Activity of CTLs and NK Cells

1999 • 123 citations

Feline Immunodeficiency Virus Infection Phenotypically and Functionally Activates Immunosuppressive CD4+CD25+ T Regulatory Cells

2004 • 110 citations

Activation of CD8+ Regulatory T Cells by Human Placental Trophoblasts

2005 • 108 citations

Testicular Immune Privilege Promotes Transplantation Tolerance by Altering the Balance between Memory and Regulatory T Cells

2005 • 107 citations

Differences in Tumor Regulatory T-Cell Localization and Activation Status Impact Patient Outcome

2009 • 104 citations

Specific enrichment of the suppressor T cell bearing I-J determinants: parallel functional and serological characterizations.

1977 • 103 citations

IL-2 Family of Cytokines in T Regulatory Cell Development and Homeostasis

2008 • 102 citations

Oral antigen inhibits priming of CD8+ CTL, CD4+ T cells, and antibody responses while activating CD8+ suppressor T cells.

1996 • 101 citations

Peripheral CD8+CD25+ T Lymphocytes from MHC Class II-Deficient Mice Exhibit Regulatory Activity

2005 • 98 citations

T cell epitope: Friend or Foe? Immunogenicity of biologics in context☆

2009 • 97 citations

Kinetics of Regulatory T Cells During Murine Pregnancy

2007 • 97 citations

ACUTE PSYCHOLOGICAL STRESS SIMULTANEOUSLY ALTERS HORMONE LEVELS, RECRUITMENT OF LYMPHOCYTE SUBSETS, AND PRODUCTION OF REACTIVE OXYGEN SPECIES

2002 • 96 citations

Immunohistochemical Analysis of Regulatory T Cell Markers FOXP3 and GITR on CD4⁺CD25⁺ T Cells in Normal Skin and Inflammatory Dermatoses

2007 • 93 citations

Comparison of decidual leukocytes following spontaneous vaginal delivery and elective cesarean section in uncomplicated human term pregnancy

2004 • 91 citations

Special regulatory T‐cell review: FOXP3 biochemistry in regulatory T cells – how diverse signals regulate suppression

2007 • 88 citations

Inflammation in the Intestinal Tract: Pathogenesis and Treatment

2009 • 88 citations

Harnessing Regulatory T cells to Suppress Asthma

2010 • 88 citations

Regulatory T‐cell differentiation versus clonal deletion of autoreactive thymocytes

2010 • 88 citations

Lymphocyte proliferation in immune-mediated diseases

2009 • 88 citations

Double Negative (CD4⁻CD8⁻αβ⁺) T Cells Which Promote Tolerance Induction and Regulate Autoimmunity

1996 • 88 citations

Oral Tolerance and Regulation of Immunity to Dietary Antigens

1994 • 86 citations

Malignant Tregs express low molecular splice forms of FOXP3 in Sézary syndrome

2008 • 85 citations

Activated CD1d‐restricted natural killer T cells secrete IL‐2: innate help for CD4⁺CD25⁺ regulatory T cells?

2005 • 84 citations

Interleukin-10 in the regulation of T cell-induced colitis

2003 • 84 citations

CD4 T cells: Balancing the coming and going of autoimmune-mediated inflammation in the CNS

2008 • 83 citations

Thymic Commitment of Regulatory T Cells Is a Pathway of TCR-Dependent Selection That Isolates Repertoires Undergoing Positive or Negative Selection

2005 • 83 citations

Natural regulatory T cells in autoimmunity

2010 • 83 citations

The novel CD4+CD25+ regulatory T cell effector molecule fibrinogen-like protein 2 contributes to the outcome of murine fulminant viral hepatitis #

2008 • 82 citations

Special regulatory T cell review: The resurgence of the concept of contrasuppression in immunoregulation

2007 • 77 citations

Role of Double-Negative Regulatory T Cells in Long-Term Cardiac Xenograft Survival

2003 • 74 citations

Emerging concepts in CD8+ T regulatory cells

2008 • 74 citations

Decrease of CD4+FOXP3+ T regulatory cells in the peripheral blood of human subjects undergoing a mental stressor

2009 • 73 citations

Preferential replication of FIV in activated CD4+CD25+T cells independent of cellular proliferation

2004 • 72 citations

Role and mechanisms of CD4+CD25+ regulatory T cells in the induction and maintenance of transplantation tolerance

2006 • 72 citations

Expression and Function of PDCD1 at the Human Maternal-Fetal Interface1

2008 • 71 citations

Double-Negative T Cells, Activated by Xenoantigen, Lyse Autologous B and T Cells Using a Perforin/Granzyme-Dependent, Fas-Fas Ligand-Independent Pathway

2006 • 70 citations

Heroes or villains? T regulatory cells in malaria infection

2009 • 69 citations

Immune tolerance in allergy

2009 • 68 citations

Tremelimumab (anti-CTLA4) mediates immune responses mainly by direct activation of T effector cells rather than by affecting T regulatory cells

2010 • 67 citations

Acute psychological stress alerts the adaptive immune response: Stress-induced mobilization of effector T cells

2006 • 67 citations

Special regulatory T‐cell review: A rose by any other name: from suppressor T cells to Tregs, approbation to unbridled enthusiasm

2007 • 64 citations

Donor Lymphocyte Infusion Induces Long-Term Donor-Specific Cardiac Xenograft Survival through Activation of Recipient Double-Negative Regulatory T Cells

2005 • 64 citations

Antigens recognized by λδ T cells

1994 • 64 citations

Regulating regulatory T cells

2006 • 59 citations

T regulatory cells: an overview and intervention techniques to modulate allergy outcome

2009 • 55 citations

CD8+ suppressor T cells resurrected

2008 • 52 citations

FOXP3+ regulatory T cells: control of FOXP3 expression by pharmacological agents

2011 • 49 citations

B-cell-derived interleukin-10 in autoimmune disease: regulating the regulators

2008 • 48 citations

T regulatory cells, the evolution of targeted immunotherapy

2010 • 44 citations

Imaging the function of regulatory T cells in vivo

2006 • 41 citations

Histone deacetylase inhibitors and transplantation

2007 • 39 citations

T regulatory cells in xenotransplantation

2009 • 35 citations

Generation of HSP60-specific regulatory T cell and effect on atherosclerosis

2006 • 34 citations

Downregulation of Innate and Acquired Antitumor Immunity by Bystander gamma delta and alpha beta T Lymphocytes with Th2 or Tr1 Cytokine Profiles

1999 • 33 citations

γδ T Cells Play an Essential Role in Several Forms of Tolerance

2004 • 30 citations

Role of Regulatory and Proinflammatory T-Cell Populations in Allergic Diseases

2008 • 25 citations

CD4+CD25+ T Regulatory Cells and TGF-β in Mucosal Immune System: The Good and the Bad

2007 • 25 citations

Special regulatory T‐cell review: regulation of immune responses – examining the role of T cells

2007 • 23 citations

Mechanisms involved in the expansion of Tregs during pregnancy: role of IL-2/STAT5 signalling

2011 • 23 citations

Foxp3 as a marker of tolerance induction versus rejection

2009 • 20 citations

T-regulatory cells in tumour-specific vaccination strategies

2008 • 17 citations

Anterior Chamber-Associated Immune Deviation

2008 • 16 citations

Regulatory B cells in autoimmune diseases and mucosal immune homeostasis

2010 • 15 citations

A short course of mycophenolate immunosuppression inhibits rejection, but not tolerance, of rat liver allografts in association with inhibition of interleukin-4 and alloantibody responses

2003 • 13 citations

The role of TGF-β in digestive organ disease

2002 • 12 citations

The role of γδ TCR-bearing T cells in oral tolerance

1997 • 12 citations

Long-term acceptance of porcine pulmonary allografts without chronic rejection

2005 • 12 citations

Effect of biologic agents on regulatory T cells

2011 • 9 citations

[The influence of mycophenolate mofetil upon the maturation and allostimulatory activity of cultured dendritic cell progenitors and the effects of tolerance induction in allograft recipients].

2005 • 9 citations

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome and the scurfy mutant mouse

2002 • 8 citations

CD4+CD25+FOXP3+ regulatory T cells in nonhuman primates

2006 • 1 citations