Th17 Response and Inflammatory Autoimmune Diseases

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

2006 • 4,815 citations

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

2005 • 4,573 citations

IL-17 and Th17 Cells

2009 • 4,491 citations

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

2005 • 4,165 citations

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

2005 • 3,961 citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

2006 • 2,903 citations

Interleukin-17 Family Members and Inflammation

2004 • 2,340 citations

Development, cytokine profile and function of human interleukin 17–producing helper T cells

2007 • 1,962 citations

Phenotypic and functional features of human Th17 cells

2007 • 1,832 citations

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

2009 • 1,826 citations

IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages

2007 • 1,809 citations

IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

2007 • 1,808 citations

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

2008 • 1,788 citations

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

2008 • 1,653 citations

Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

2003 • 1,652 citations

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

2010 • 1,474 citations

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

2009 • 1,447 citations

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

2007 • 1,446 citations

Structure and signalling in the IL-17 receptor family

2009 • 1,328 citations

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

2010 • 1,304 citations

Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

2009 • 1,296 citations

Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice

2003 • 1,280 citations

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

2009 • 1,144 citations

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

2011 • 1,093 citations

Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells

2008 • 1,020 citations

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

2011 • 999 citations

Differential Roles of Interleukin-17A and -17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses

2009 • 976 citations

Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system

2006 • 947 citations

Phagocytosis of Apoptotic Neutrophils Regulates Granulopoiesis via IL-23 and IL-17

2005 • 895 citations

IL-21 and TGF-β are required for differentiation of human TH17 cells

2008 • 882 citations

Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation

2011 • 834 citations

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

2003 • 822 citations

IL-18: A TH1 -inducing, proinflammatory cytokine and new member of the IL-1 family

1999 • 806 citations

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

2008 • 762 citations

Still's disease in the adult.

1971 • 735 citations

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

2009 • 729 citations

Regulation of inflammatory responses by IL-17F

2008 • 729 citations

Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines

2010 • 638 citations

Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial

2009 • 574 citations

Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3− and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner

2011 • 568 citations

Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells

2007 • 540 citations

Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction

2008 • 530 citations

Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: Implications for Th17-mediated inflammation in auto-immunity

2008 • 528 citations

Preferential recruitment of interferon‐γ–expressing T_H17 cells in multiple sclerosis

2009 • 507 citations

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

2011 • 504 citations

Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

2008 • 504 citations

Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus

2000 • 472 citations

The roles of IL‐17A in inflammatory immune responses and host defense against pathogens

2008 • 472 citations

Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice

2003 • 470 citations

T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis

2007 • 469 citations

Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

2008 • 461 citations

LY2439821, a humanized anti–interleukin‐17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double‐blind, placebo‐controlled, proof‐of‐concept study

2010 • 452 citations

Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

2009 • 452 citations

Enhancing Effect of IL-17 on IL-1-Induced IL-6 and Leukemia Inhibitory Factor Production by Rheumatoid Arthritis Synoviocytes and Its Regulation by Th2 Cytokines

1998 • 451 citations

Th17 and natural Treg cell population dynamics in systemic lupus erythematosus

2009 • 438 citations

RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F

2008 • 425 citations

A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice

2005 • 423 citations

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

2009 • 401 citations

Signals mediated by transforming growth factor-β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease

2006 • 392 citations

Halofuginone Inhibits T _H 17 Cell Differentiation by Activating the Amino Acid Starvation Response

2009 • 387 citations

Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis

2009 • 378 citations

Inhibition of Th17 Cells Regulates Autoimmune Diabetes in NOD Mice

2009 • 368 citations

Identification of the IL-17 Receptor Related Molecule IL-17RC as the Receptor for IL-17F

2007 • 333 citations

IL-17 Stimulates Granulopoiesis in Mice: Use of an Alternate, Novel Gene Therapy-Derived Method for In Vivo Evaluation of Cytokines

1998 • 320 citations

Overrepresentation of IL-17A and IL-22 Producing CD8 T Cells in Lesional Skin Suggests Their Involvement in the Pathogenesis of Psoriasis

2010 • 304 citations

Adult Still's disease: review of 228 cases from the literature.

1987 • 279 citations

CD4+CD25+Foxp3+ Regulatory T Cells Promote Th17 Cells In Vitro and Enhance Host Resistance in Mouse Candida albicans Th17 Cell Infection Model

2011 • 270 citations

Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still's disease

2001 • 267 citations

Requirement of Endogenous Stem Cell Factor and Granulocyte-Colony-Stimulating Factor for IL-17-Mediated Granulopoiesis

2000 • 266 citations

Proinflammatory cytokine profiles in sera and pathological tissues of patients with active untreated adult onset Still's disease.

2004 • 251 citations

Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection

2009 • 239 citations

Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice

2008 • 232 citations

IL-23–Mediated Psoriasis-Like Epidermal Hyperplasia Is Dependent on IL-17A

2010 • 227 citations

CCR6 is required for IL-23–induced psoriasis-like inflammation in mice

2009 • 220 citations

Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation

2009 • 216 citations

IL-23 Drives Pathogenic IL-17-Producing CD8+ T Cells

2009 • 210 citations

Signal transduction pathways and transcriptional regulation in Th17 cell differentiation

2010 • 209 citations

Serum cytokine profiles in patients with adult onset Still's disease.

2003 • 193 citations

Interleukin 17 levels are increased in juvenile idiopathic arthritis synovial fluid and induce synovial fibroblasts to produce proinflammatory cytokines and matrix metalloproteinases.

2008 • 182 citations

Distinct Roles of IL-23 and IL-17 in the Development of Psoriasis-Like Lesions in a Mouse Model

2011 • 154 citations

Leukemia Inhibitory Factor Inhibits T Helper 17 Cell Differentiation and Confers Treatment Effects of Neural Progenitor Cell Therapy in Autoimmune Disease

2011 • 150 citations

Foxp3+ Regulatory T Cells Promote T Helper 17 Cell Development In Vivo through Regulation of Interleukin-2

2011 • 144 citations

Prevalent vertebral fractures among children initiating glucocorticoid therapy for the treatment of rheumatic disorders

2010 • 143 citations

Predominance of Th1 cytokine in peripheral blood and pathological tissues of patients with active untreated adult onset Still's disease

2004 • 137 citations

CD11b+ Monocytes Abrogate Th17 CD4+ T Cell-Mediated Experimental Autoimmune Myocarditis

2008 • 133 citations

IL-27 Regulates IL-10 and IL-17 from CD4+ Cells in Nonhealing Leishmania major Infection

2009 • 127 citations

Autoimmunity induction by human T cell leukemia virus type 1 in transgenic mice that develop chronic inflammatory arthropathy resembling rheumatoid arthritis in humans.

1995 • 117 citations

IL-17RC: a partner in IL-17 signaling and beyond

2009 • 94 citations

Potential role of Th17 cells in the pathogenesis of adult-onset Still's disease

2010 • 84 citations

Interleukin-6 inhibition for treatment of rheumatoid arthritis: A review of tocilizumab therapy

2010 • 82 citations

IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-γ

2000 • 79 citations

HMGB1 blockade attenuates experimental autoimmune myocarditis and suppresses Th17‐cell expansion

2011 • 76 citations

IL-23-Mediated Epidermal Hyperplasia Is Dependent on IL-6

2011 • 65 citations

Actual status of antiinterleukin-1 therapies in rheumatic diseases

2010 • 61 citations

Alteration of IL-17 Related Protein Expressions in Experimental Autoimmune Myocarditis and Inhibition of IL-17 by IL-10-Ig Fusion Gene Transfer

2008 • 49 citations

TNF, but Not IL-6 and IL-17, Is Crucial for the Development of T Cell-Independent Psoriasis-Like Dermatitis in Il1rn−/− Mice

2010 • 42 citations

Memory CD4+CD127high T cells from patients with multiple sclerosis produce IL-17 in response to myelin antigens

2010 • 42 citations

Increased serum interleukin‐17 and peripheral Th17 cells in children with acute Henoch–Schönlein purpura

2011 • 42 citations

Comparing biological therapies in psoriasis: implications for clinical practice

2010 • 16 citations

Autoimmune hepatitis with raised alpha-fetoprotein level as the presenting symptoms of systemic lupus erythematosus: a case report

2006 • 14 citations