Adenosine, an endogenous anti-inflammatory agent

ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS

1979 • 1,370 citations

Subclasses of external adenosine receptors.

1980 • 1,087 citations

Turnover of adenosine in plasma of human and dog blood

1989 • 524 citations

Adenosine: a physiological modulator of superoxide anion generation by human neutrophils.

1983 • 467 citations

Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin

1984 • 418 citations

Adenosine: an endogenous inhibitor of neutrophil-mediated injury to endothelial cells.

1986 • 416 citations

Neutrophil adherence to endothelium is enhanced via adenosine A1 receptors and inhibited via adenosine A2 receptors.

1992 • 361 citations

Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells.

1991 • 336 citations

Potentiation of Mast Cell Mediator Release by Adenosine

1978 • 273 citations

The adhesion molecules of inflammation

1993 • 257 citations

Dependence of an adenosine-activated potassium current on a GTP-binding protein in mammalian central neurons

1987 • 254 citations

Pertussis toxin reverses adenosine inhibition of neuronal glutamate release

1985 • 247 citations

Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes

1985 • 229 citations

Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5′-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide

1986 • 203 citations

Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injury.

1989 • 203 citations

Cloned receptors and cardiovascular responses to adenosine

1993 • 195 citations

Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes.

1985 • 192 citations

Adenosine and a related carbocyclic nucleoside analogue selectively inhibit tumor necrosis factor-alpha production and protect mice against endotoxin challenge.

1993 • 192 citations

Chemotactic peptide activation of human neutrophils and HL-60 cells. Pertussis toxin reveals correlation between inositol trisphosphate generation, calcium ion transients, and cellular activation.

1985 • 182 citations

Adenosine inhibits and potentiates IgE-dependent histamine release from human lung mast cells by an A2-purinoceptor mediated mechanism

1984 • 179 citations

Pertussis toxin inhibits fMet-Leu-Phe- but not phorbol ester-stimulated changes in rabbit neutrophils: role of G proteins in excitation response coupling.

1985 • 175 citations

Chemoattractant-stimulated polymorphonuclear leukocytes contain two populations of actin filaments that differ in their spatial distributions and relative stabilities.

1990 • 165 citations

Inhibitory effect of prostaglandin E2, forskolin, and dibutyryl cAMP on arachidonic acid release and inositol phospholipid metabolism in guinea pig neutrophils.

1986 • 164 citations

The inhibition of neutrophil granule enzyme secretion and chemotaxis by pertussis toxin.

1985 • 155 citations

Changes in cytoskeletal proteins of polymorphonuclear leukocytes induced by chemotactic peptides

1983 • 153 citations

Heterologous desensitization of the inhibitory A1 adenosine receptor-adenylate cyclase system in rat adipocytes. Regulation of both Ns and Ni.

1987 • 149 citations

Adenosine receptor down-regulation and insulin resistance following prolonged incubation of adipocytes with an A1 adenosine receptor agonist.

1987 • 148 citations

Rapid modulation of N-formyl chemotactic peptide receptors on the surface of human granulocytes: formation of high-affinity ligand-receptor complexes in transient association with cytoskeleton.

1984 • 145 citations

Receptor-cytoskeleton interactions and membrane traffic may regulate chemoattractant-induced superoxide production in human granulocytes.

1986 • 144 citations

Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate.

1987 • 140 citations

Extraction Procedures for Use Prior to HPLC Nucleotide Analysis Using Microparticle Chemically Bonded Packings

1977 • 131 citations

Fc gamma receptor-mediated functions in neutrophils are modulated by adenosine receptor occupancy. A1 receptors are stimulatory and A2 receptors are inhibitory.

1990 • 126 citations

The control of adenosine concentration in polymorphonuclear leucocytes, cultured heart cells and isolated perfused heart from the rat

1983 • 113 citations

Inhibition by adenosine of reactive oxygen metabolite production by human polymorphonuclear leucocytes

1985 • 111 citations

Adenosine promotes neutrophil chemotaxis.

1988 • 109 citations

Inhibition of folate-dependent enzymes by non-steroidal anti-inflammatory drugs

1992 • 106 citations

Lateral segregation of neutrophil chemotactic receptors into actin- and fodrin-rich plasma membrane microdomains depleted in guanyl nucleotide regulatory proteins.

1988 • 99 citations

Bone marrow transplantation only partially restores purine metabolites to normal in adenosine deaminase-deficient patients.

1981 • 97 citations

The role of agonists that activate adenylate cyclase in the control of cAMP metabolism and enzyme release by human polymorphonuclear leukocytes.

1980 • 92 citations

Stimulus-Specific Effects of Pentoxifylline on Neutrophil CR3 Expression, Degranulation, and Superoxide Production

1990 • 87 citations

Occupancy of adenosine receptors raises cyclic AMP alone and in synergy with occupancy of chemoattractant receptors and inhibits membrane depolarization

1988 • 85 citations

A pertussis toxin-sensitive GTP-binding protein in the human neutrophil regulates multiple receptors, calcium mobilization, and lectin-induced capping.

1985 • 83 citations

Leukocyte adherence in rat mesenteric venules: Effects of adenosine and methotrexate

1993 • 78 citations

Adenosine receptors on mouse bone marrow-derived mast cells: functional significance and regulation by aminophylline.

1984 • 75 citations

Chemotactic Peptide Induces cAMP Elevation in Human Neutrophils by Amplification of the Adenylate Cyclase Response to Endogenously Produced Adenosine

1989 • 74 citations

The antiinflammatory effects of adenosine receptor agonists on the carrageenan-induced pleural inflammatory response in rats.

1990 • 69 citations

Regulation of chemoattractant receptor interaction with transducing proteins by organizational control in the plasma membrane of human neutrophils.

1989 • 64 citations

Effect of adenosine analogues and cAMP-raising agents on TNF-, GM-CSF–, and chemotactic peptide–induced degranulation in single adherent neutrophils

1992 • 63 citations

Adenosine regulates the respiratory burst of cytokine-triggered human neutrophils adherent to biologic surfaces.

1989 • 62 citations

Occupancy of G alpha s-linked receptors uncouples chemoattractant receptors from their stimulus-transduction mechanisms in the neutrophil

1992 • 55 citations

Attenuation of no-reflow phenomenon, neutrophil activation, and reperfusion injury in intestinal microcirculation by topical adenosine.

1989 • 55 citations

Interstitial Transudate Purines in Normoxic and Hypoxic Immature and Mature Rabbit Hearts

1990 • 53 citations

Reciprocal modulation of agonist and antagonist binding to A1 adenosine receptors by guanine nucleotides is mediated via a pertussis toxin-sensitive G protein.

1988 • 52 citations

Inhibition of Neutrophil Superoxide Production by Adenosine Released from Vascular Endothelial Cells

1991 • 50 citations

Adenosine Inhibition of the Hormonal Response in the Sertoli Cell Is Reversed by Pertussis Toxin*

1988 • 48 citations

Exposure of human neutrophils to exogenous nucleotides causes elevation in intracellular calcium, transmembrane calcium fluxes, and an alteration of a cytosolic factor resulting in enhanced superoxide production in response to FMLP and arachidonic acid

1990 • 48 citations

Selective adenosine release from human B but not T lymphoid cell line.

1990 • 45 citations

Regulation of human neutrophil functions by adenine nucleotides.

1989 • 42 citations

Rat fat-cells have three types of adenosine receptors (Ra, Ri and P). Differential effects of pertussis toxin

1985 • 41 citations

Adenosine potentiates immunological histamine release from rat mast cells by a novel cyclic AMP‐independent cell‐surface action

1985 • 40 citations

Multiple effects of dipyridamole on neutrophils and mononuclear leukocytes: adenosine-dependent and adenosine-independent mechanisms.

1991 • 35 citations

Effects of adenosine on polymorphonuclear leucocyte function, cyclic 3′:5′‐adenosine monophosphate, and intracellular calcium

1989 • 34 citations

Regulation of oxygen radical production of human polymorphonuclear leukocytes by adenosine: the role of calcium

1992 • 31 citations

Dynamics of chemotactic peptide-induced superoxide generation by human monocytes

1987 • 25 citations

Adenosine inhibits divalent cation influx across human neutrophil plasma membrane via surface adenosine A2 receptors

1992 • 24 citations

Pertussis toxin reverses adenosine receptor-mediated inhibition of renin secretion in rat renal cortical slices

1987 • 22 citations

Regulation of superoxide responses of human neutrophils by adenine compounds. Independence of requirement for cytoplasmic granules.

1989 • 19 citations

Attenuation of LPS-induced neutrophil thromboxane B2 release and chemiluminescence

1991 • 18 citations

Separate purinoceptors mediate enhancement by adenosine of concanavalin A-induced mediator release and the cyclic AMP response in rat mast cells

1986 • 18 citations

Differing calcium requirements for regulatory effects of ATP, ATPγS and adenosine on O2• responses of human neutrophils

1988 • 17 citations

Synergistic effects of calcium‐mobilizing agents and adenosine on histamine release from rat peritoneal mast cells

1989 • 12 citations

EFFECTS OF ADENOSINE AND ITS ANALOGUES ON ACTIN POLYMERIZATION IN HUMAN POLYMORPHONUCLEAR LEUCOCYTES

1993 • 11 citations

Adenosine system and cell calcium translocation: Interference of calcium channel blockers

1990 • 11 citations

Inhibition of the zymosan-induced chemiluminescence of human phagocytes by adenosine, polyadenylic acid and agents influencing adenosine metabolism.

1989 • 9 citations

Nucleoside transport inhibition and fMLP-stimulated whole blood luminescence

1991 • 9 citations

Inhibition of thyrotropin-stimulated adenosine 3',5'-monophosphate formation in rat thyroid cells by an adenosine analog. Evidence that the inhibition is mediated by the putative inhibitory guanine nucleotide regulatory protein.

1986 • 9 citations