External Beam Radiation of Tumors Alters Phenotype of Tumor Cells to Render Them Susceptible to Vaccine-Mediated T-Cell Killing

Induction of Tumor Cell Apoptosis In Vivo Increases Tumor Antigen Cross-Presentation, Cross-Priming Rather than Cross-Tolerizing Host Tumor-Specific CD8 T Cells

2003 • 441 citations

The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity

2000 • 440 citations

The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product.

1996 • 386 citations

Phase I Study in Advanced Cancer Patients of a Diversified Prime-and-Boost Vaccination Protocol Using Recombinant Vaccinia Virus and Recombinant Nonreplicating Avipox Virus to Elicit Anti–Carcinoembryonic Antigen Immune Responses

2000 • 363 citations

Workshop R: Tumor Immunology, Abstract R1 bis R30

2001 • 312 citations

A triad of costimulatory molecules synergize to amplify T-cell activation.

1999 • 293 citations

Role of Fas-mediated cell death in the regulation of immune responses

1996 • 243 citations

Diversified prime and boost protocols using recombinant vaccinia virus and recombinant non-replicating avian pox virus to enhance T-cell immunity and antitumor responses

1997 • 209 citations

The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product

1996 • 206 citations

Immune Modulation by Ionizing Radiation and its Implications for Cancer Immunotherapy

2002 • 200 citations

Definition by monoclonal antibodies of a repertoire of epitopes on carcinoembryonic antigen differentially expressed in human colon carcinomas versus normal adult tissues.

1985 • 177 citations

Enhancing Efficacy of Recombinant Anticancer Vaccines With Prime/Boost Regimens That Use Two Different Vectors

1997 • 158 citations

Transduction and expression of the human carcinoembryonic antigen gene in a murine colon carcinoma cell line.

1991 • 149 citations

Synergy of vaccine strategies to amplify antigen-specific immune responses and antitumor effects.

2001 • 137 citations

Mice transgenic for the human carcinoembryonic antigen gene maintain its spatiotemporal expression pattern.

1994 • 135 citations

RMA/S cells present endogenously synthesized cytosolic proteins to class I-restricted cytotoxic T lymphocytes.

1992 • 132 citations

Up-regulation of Fas (CD95) in human p53wild-type cancer cells treated with ionizing radiation

1997 • 128 citations

Tumor-Specific CTL Kill Murine Renal Cancer Cells Using Both Perforin and Fas Ligand-Mediated Lysis In Vitro, But Cause Tumor Regression In Vivo in the Absence of Perforin

2002 • 128 citations

Granulocyte/macrophage-colony stimulating factor produced by recombinant avian poxviruses enriches the regional lymph nodes with antigen-presenting cells and acts as an immunoadjuvant.

2001 • 126 citations

Progress in the development of immunotherapy for the treatment of patients with cancer

2001 • 124 citations

Enhanced Activation of T Cells by Dendritic Cells Engineered to Hyperexpress a Triad of Costimulatory Molecules

2000 • 97 citations

Irradiation induced expression of CD31, ICAM-1 and VCAM-1 in human microvascular endothelial cells.

2000 • 95 citations

Treatment of human colon carcinoma cell lines with anti-neoplastic agents enhances their lytic sensitivity to antigen-specific CD8 + cytotoxic T lymphocytes

2001 • 89 citations

MHC class I-restricted epitope spreading in the context of tumor rejection following vaccination with a single immunodominant CTL epitope

1999 • 86 citations

Costimulation Enhances the Active Immunotherapy Effect of Recombinant Anticancer Vaccines

1996 • 84 citations

Mechanisms of Lysis by Cytotoxic T Cells

1995 • 79 citations

IFN-γ-Dependent Delay of In Vivo Tumor Progression by Fas Overexpression on Murine Renal Cancer Cells

2000 • 72 citations

Radiation-enhanced expression of E6/E7 transforming oncogenes of human papillomavirus-16 in human cervical carcinoma

1998 • 67 citations

Peptide Modification or Blocking of CD8, Resulting in Weak TCR Signaling, Can Activate CTL for Fas- But Not Perforin-Dependent Cytotoxicity or Cytokine Production

1998 • 65 citations

The Envelope Protein of an Endogenous Murine Retrovirus Is a Tumor-Associated T-Cell Antigen for Multiple Murine Tumors

2000 • 64 citations

Effects of irradiation on the expression of major histocompatibility complex class I antigen and adhesion costimulation molecules ICAM-1 in human cervical cancer

1997 • 62 citations

Antitumor efficacy of wild-type p53-specific CD4(+) T-helper cells.

2002 • 57 citations

Potential for specific cancer therapy with immune T lymphocytes.

1984 • 48 citations

Regression of Extensive Pulmonary Metastases in Mice by Adoptive Transfer of Antigen-Specific CD8+ CTL Reactive Against Tumor Cells Expressing a Naturally Occurring Rejection Epitope

2001 • 47 citations

Identification of an interferon-gamma-inducible carcinoembryonic antigen (CEA) CD8(+) T-cell epitope, which mediates tumor killing in CEA transgenic mice.

2002 • 43 citations

Broadening of Epitope Recognition During Immune Rejection of ErbB-2-Positive Tumor Prevents Growth of ErbB-2-Negative Tumor

2003 • 42 citations

The cytotoxic T-lymphocyte response against a poorly immunogenic mammary adenocarcinoma is focused on a single immunodominant class I epitope derived from the gp70 Env product of an endogenous retrovirus.

2003 • 42 citations

Cytotoxic Lymphocytes: Two ways to kill target cells

1994 • 40 citations

Characterization of CD8 + cytotoxic T lymphocyte/tumor cell interactions reflecting recognition of an endogenously expressed murine wild-type p53 determinant

2001 • 39 citations

Effects of gemcitabine on cell proliferation and apoptosis in non-small-cell lung cancer (NSCLC) cell lines

2000 • 33 citations

Fractionated γ-irradiation renders tumour cells more responsive to apoptotic signals through CD95

1999 • 29 citations

CD80 (B7.1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T cell lysis.

1996 • 26 citations

Enhanced apoptosis of squamous cell carcinoma cells by interleukin-2-activated cytotoxic lymphocytes combined with radiation and anticancer drugs

2000 • 26 citations

A wild‐type p53 cytotoxic T cell epitope is presented by mouse hepatocarcinoma cells

1996 • 22 citations

Strategies in the development of recombinant vaccines for colon cancer.

1999 • 19 citations

Participation of Fas-mediated apoptotic pathway in KB, a human head and neck squamous cell carcinoma cell line, after irradiation

2002 • 12 citations

Cytotoxicity of Fas ligand against lymphoma cells with radiation-induced Fas antigen.

1998 • 2 citations

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