Tumor stress, cell death and the ensuing immune response

The Hallmarks of Cancer

2000 • 27,569 citations

Inflammation and cancer: back to Virchow?

2001 • 7,259 citations

Cancer immunoediting: from immunosurveillance to tumor escape

2002 • 4,911 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

2002 • 4,011 citations

Nuclear factor-κB in cancer development and progression

2006 • 3,334 citations

NF-κB: linking inflammation and immunity to cancer development and progression

2005 • 2,878 citations

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

2007 • 2,814 citations

Calreticulin exposure dictates the immunogenicity of cancer cell death

2006 • 2,789 citations

DAMPs, PAMPs and alarmins: all we need to know about danger

2006 • 2,668 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

1996 • 2,387 citations

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

2007 • 2,297 citations

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

2003 • 2,177 citations

Putting tumours in context

2001 • 2,145 citations

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

1998 • 2,114 citations

Regulatory T cells, tumour immunity and immunotherapy

2006 • 2,009 citations

A cytokine-mediated link between innate immunity, inflammation, and cancer

2007 • 1,867 citations

Smoldering and polarized inflammation in the initiation and promotion of malignant disease

2005 • 1,730 citations

Molecular identification of a danger signal that alerts the immune system to dying cells

2003 • 1,649 citations

Immunological aspects of cancer chemotherapy

2007 • 1,535 citations

Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma

2002 • 1,454 citations

Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

2005 • 1,330 citations

Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

2007 • 1,306 citations

Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway

2000 • 1,299 citations

Cancer despite immunosurveillance: immunoselection and immunosubversion

2006 • 1,263 citations

Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity

2003 • 1,255 citations

The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

2005 • 1,246 citations

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

2003 • 1,132 citations

Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.

2001 • 1,126 citations

The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

2005 • 1,063 citations

Gemcitabine Selectively Eliminates Splenic Gr-1+/CD11b+ Myeloid Suppressor Cells in Tumor-Bearing Animals and Enhances Antitumor Immune Activity

2005 • 1,010 citations

Stromal Effects on Mammary Gland Development and Breast Cancer

2002 • 902 citations

CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent manner

2005 • 889 citations

CD4⁺CD25⁺ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative

2004 • 854 citations

Overexpression of Cyclooxygenase-2 Is Sufficient to Induce Tumorigenesis in Transgenic Mice

2001 • 809 citations

The tumour microenvironment as a target for chemoprevention

2007 • 790 citations

Cell death modalities: classification and pathophysiological implications

2007 • 772 citations

Cancer--A Biological Approach: I. The Processes Of Control. II. The Significance of Somatic Mutation

1957 • 732 citations

Clinical significance of defective dendritic cell differentiation in cancer.

2000 • 694 citations

Inflammation and necrosis promote tumour growth

2004 • 646 citations

Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFNγ receptors

1994 • 619 citations

HMGB1 is an endogenous immune adjuvant released by necrotic cells

2004 • 576 citations

Heterotypic Signaling between Epithelial Tumor Cells and Fibroblasts in Carcinoma Formation

2001 • 554 citations

Cellular and Humoral Aspects of the Hypersensitive States

1959 • 549 citations

Tregs and rethinking cancer immunotherapy

2007 • 532 citations

The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy

2007 • 531 citations

Tumor-Specific Human CD4+ Regulatory T Cells and Their Ligands

2004 • 525 citations

Friendly and dangerous signals: is the tissue in control?

2006 • 525 citations

Decreased tumor surveillance in perforin-deficient mice.

1996 • 487 citations

TLR3 Can Directly Trigger Apoptosis in Human Cancer Cells

2006 • 464 citations

High Mobility Group Box Protein 1: An Endogenous Signal for Dendritic Cell Maturation and Th1 Polarization

2004 • 435 citations

Extracellular role of HMGB1 in inflammation and sepsis

2004 • 430 citations

Regulatory T cells under scrutiny

2003 • 427 citations

Know thy neighbor: stromal cells can contribute oncogenic signals

2001 • 422 citations

Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance

2005 • 422 citations

Natural Killer Cells Activated by MHC Class ILow Targets Prime Dendritic Cells to Induce Protective CD8 T Cell Responses

2003 • 416 citations

A novel dendritic cell subset involved in tumor immunosurveillance

2006 • 407 citations

Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors.

2003 • 401 citations

CD4+CD25+ T Regulatory Cells Suppress NK Cell-Mediated Immunotherapy of Cancer

2006 • 395 citations

Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity

2006 • 393 citations

Apoptotic Vesicles Crossprime CD8 T Cells and Protect against Tuberculosis

2006 • 392 citations

A Critical Role for Stat3 Signaling in Immune Tolerance

2003 • 388 citations

Bortezomib enhances dendritic cell (DC)–mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications

2007 • 367 citations

Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells

2007 • 351 citations

Natural Killer Cell–Mediated Lysis of Hepatoma Cells via Specific Induction of NKG2D Ligands by the Histone Deacetylase Inhibitor Sodium Valproate

2005 • 351 citations

Antitumor effect of locally produced CD95 ligand

1997 • 315 citations

Prevalent expression of the immunostimulatory MHC class I chain–related molecule is counteracted by shedding in prostate cancer

2004 • 297 citations

Cancer Cells Become Susceptible to Natural Killer Cell Killing after Exposure to Histone Deacetylase Inhibitors Due to Glycogen Synthase Kinase-3–Dependent Expression of MHC Class I–Related Chain A and B

2005 • 260 citations

Prevalent expression of the immunostimulatory MHC class I chain–related molecule is counteracted by shedding in prostate cancer

2004 • 253 citations

Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor

2003 • 241 citations

Gemcitabine exerts a selective effect on the humoral immune response: implications for combination chemo-immunotherapy.

2002 • 235 citations

How the immune system protects the host from infection

2001 • 225 citations

Tumour escape from immune surveillance through dendritic cell inactivation

2002 • 221 citations

DC-NK cell cross talk as a novel CD4+ T-cell–independent pathway for antitumor CTL induction

2005 • 221 citations

Requirement of HMGB1 and RAGE for the maturation of human plasmacytoid dendritic cells

2005 • 193 citations

Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models

2007 • 191 citations

Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling

2006 • 170 citations

Eosinophilic Granulocytes and Damage-associated Molecular Pattern Molecules (DAMPs)

2006 • 160 citations

Pivotal Advance: Eosinophil infiltration of solid tumors is an early and persistent inflammatory host response

2006 • 159 citations

Rat Spleen Dendritic Cells Express Natural Killer Cell Receptor Protein 1 (NKR-P1) and Have Cytotoxic Activity to Select Targets via a Ca2+-dependent Mechanism

1997 • 159 citations

The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis

2007 • 158 citations

Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells

2006 • 153 citations

Apoptotic Cells Deliver Processed Antigen to Dendritic Cells for Cross-Presentation

2005 • 148 citations

Natural Killer Dendritic Cells Have Both Antigen Presenting and Lytic Function and in Response to CpG Produce IFN-γ via Autocrine IL-12

2005 • 145 citations

Harnessing the immune system to treat cancer

2007 • 130 citations

Activation of Tumor-Associated Macrophages by the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid Induces an Effective CD8+ T-Cell–Mediated Antitumor Immune Response in Murine Models of Lung Cancer and Mesothelioma

2005 • 128 citations

Immune Response Against Dying Tumor Cells

2004 • 121 citations

CD11chigh Dendritic Cell Ablation Impairs Lymphopenia-Driven Proliferation of Naive and Memory CD8+ T Cells

2005 • 99 citations

Cytolytic cells induce HMGB1 release from melanoma cell lines

2006 • 94 citations

Murine CTLA4-IgG Treatment Inhibits Airway Eosinophilia and Hyperresponsiveness and Attenuates IgE Upregulation in a Murine Model of Allergic Asthma

1997 • 92 citations

Current development status of small-molecule vascular disrupting agents.

2006 • 92 citations

Recovery of CD8+ T-Cell Function During Systemic Chemotherapy in Advanced Ovarian Cancer

2005 • 82 citations

Redundant cell death mechanisms as relics and backups

2005 • 80 citations

Partial, but not Complete, Tumor-Debulking Surgery Promotes Protective Antitumor Memory when Combined with Chemotherapy and Adjuvant Immunotherapy

2005 • 73 citations

Immune suppression by tumor-specific CD4+ regulatory T-cells in cancer

2005 • 65 citations

Cutting Edge: Cross-Presentation as a Mechanism for Efficient Recruitment of Tumor-Specific CTL to the Brain

2003 • 61 citations

Links between innate and cognate tumor immunity

2007 • 58 citations

Therapy-Induced Tumor Immunosurveillance Involves IFN-Producing Killer Dendritic Cells

2007 • 35 citations

Interferon-γ is produced by another player of innate immune responses: The interferon-producing killer dendritic cell (IKDC)

2007 • 28 citations

Infiltrating neutrophils induce allospecific CTL in response to immunization with apoptotic cells via MCP-1 production

2006 • 24 citations

Toll-like receptor interference in myeloid dendritic cells through head and neck cancer.

2007 • 10 citations