Intracellular pattern recognition receptors in the host response

Innate Immune Recognition

2002 • 8,157 citations

Toll-like receptor signalling

2004 • 7,983 citations

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

2001 • 5,526 citations

The Inflammasome

2002 • 5,445 citations

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

2001 • 4,997 citations

Gout-associated uric acid crystals activate the NALP3 inflammasome

2006 • 4,851 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

Toll-like receptors and innate immunity

2001 • 4,138 citations

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

2004 • 3,745 citations

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

2006 • 3,607 citations

Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

2005 • 3,059 citations

Inflammatory Bowel Disease

2002 • 3,038 citations

Cryopyrin activates the inflammasome in response to toxins and ATP

2006 • 2,874 citations

Antiviral Actions of Interferons

2001 • 2,683 citations

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

2005 • 2,449 citations

Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection

2003 • 2,325 citations

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

2005 • 2,312 citations

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

2004 • 1,769 citations

VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling

2005 • 1,761 citations

Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract

2005 • 1,741 citations

NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

2004 • 1,663 citations

Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2

2003 • 1,651 citations

Molecular identification of a danger signal that alerts the immune system to dying cells

2003 • 1,649 citations

Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity

2005 • 1,602 citations

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

2001 • 1,593 citations

Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-κB

2001 • 1,331 citations

Cell Type-Specific Involvement of RIG-I in Antiviral Response

2005 • 1,311 citations

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

2003 • 1,265 citations

Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

2004 • 1,178 citations

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

2006 • 1,104 citations

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

2006 • 1,099 citations

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

2006 • 1,097 citations

Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF

2005 • 1,062 citations

NOD-LRR PROTEINS: Role in Host-Microbial Interactions and Inflammatory Disease

2005 • 970 citations

The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN -β promoter

2004 • 947 citations

Critical Role for NALP3/CIAS1/Cryopyrin in Innate and Adaptive Immunity through Its Regulation of Caspase-1

2006 • 947 citations

Inflammatory Caspases

2004 • 917 citations

Innate Immunity Gone Awry: Linking Microbial Infections to Chronic Inflammation and Cancer

2006 • 917 citations

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

2005 • 915 citations

An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

2003 • 907 citations

Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

2005 • 847 citations

Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity

2005 • 799 citations

Spectrum of clinical features in Muckle‐Wells syndrome and response to anakinra

2004 • 746 citations

Nod2 Mutation in Crohn's Disease Potentiates NF-κB Activity and IL-1ß Processing

2005 • 745 citations

Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.

1994 • 725 citations

Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB

1999 • 725 citations

NLRs join TLRs as innate sensors of pathogens

2005 • 663 citations

The RNA Helicase Lgp2 Inhibits TLR-Independent Sensing of Viral Replication by Retinoic Acid-Inducible Gene-I

2005 • 602 citations

The Specific and Essential Role of MAVS in Antiviral Innate Immune Responses

2006 • 588 citations

Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome

2004 • 568 citations

Inflammatory Bowel Disease

1991 • 562 citations

Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist

2004 • 547 citations

Flagellin-Deficient Legionella Mutants Evade Caspase-1- and Naip5-Mediated Macrophage Immunity

2006 • 527 citations

The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

2006 • 517 citations

Blocking IL-1 in systemic inflammation

2005 • 497 citations

Toll‐like receptor 2‐dependent bacterial sensing does not occur via peptidoglycan recognition

2004 • 492 citations

Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection

2006 • 485 citations

Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor- B activation: common genetic etiology with Blau syndrome

2004 • 473 citations

Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition

2004 • 358 citations

Does Toll-like receptor 3 play a biological role in virus infections?

2004 • 354 citations

NOD2 and Toll-Like Receptors Are Nonredundant Recognition Systems of Mycobacterium tuberculosis

2005 • 351 citations

CATERPILLER: A Novel Gene Family Important in Immunity, Cell Death, and Diseases

2004 • 351 citations

Structure of the apoptotic protease-activating factor 1 bound to ADP

2005 • 337 citations

Plant innate immunity – direct and indirect recognition of general and specific pathogen-associated molecules

2003 • 334 citations

Nucleotide-binding Oligomerization Domain Proteins Are Innate Immune Receptors for Internalized Streptococcus pneumoniae

2004 • 328 citations

Potassium-inhibited processing of IL-1 beta in human monocytes.

1995 • 282 citations

Regulation of IL-8 and IL-1 expression in Crohn's disease associated NOD2/CARD15 mutations

2004 • 264 citations

hPepT1 transports muramyl dipeptide, activating NF-κB and stimulating IL-8 secretion in human colonic Caco2/bbe cells

2004 • 224 citations

ASC is essential for LPS‐induced activation of procaspase‐1 independently of TLR‐associated signal adaptor molecules

2004 • 181 citations

Expression of interleukin 1β and interleukin 1β converting enzyme by intestinal macrophages in health and inflammatory bowel disease

1998 • 178 citations

NOD2 and Crohn’s Disease: Loss or Gain of Function?

2005 • 174 citations

P2X7 Receptors Regulate NKT Cells in Autoimmune Hepatitis

2006 • 98 citations

Increased Mature Interleukin-1β (IL-1β) Secretion from THP-1 Cells Induced by Nigericin Is a Result of Activation of p45 IL-1β-converting Enzyme Processing

1998 • 80 citations

Consequence of functional Nod2 and Tlr4 mutations on gene transcription in Crohn’s disease patients

2005 • 59 citations

Naip5/Birc1e and susceptibility to Legionella pneumophila

2005 • 54 citations

Genetic clues to understanding periodic fevers, and possible therapies

2002 • 46 citations