Cancer immunotherapy comes of age

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

2010 • 14,016 citations

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

2011 • 7,390 citations

Myeloid-derived suppressor cells as regulators of the immune system

2009 • 6,165 citations

Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

2006 • 5,923 citations

Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion

2011 • 5,649 citations

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

2010 • 5,069 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

PD-1 and Its Ligands in Tolerance and Immunity

2008 • 4,838 citations

Human mesenchymal stem cells modulate allogeneic immune cell responses

2004 • 4,360 citations

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

2011 • 4,304 citations

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

2011 • 3,283 citations

Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

2003 • 3,194 citations

Tolerogenic Dendritic Cells

2003 • 3,131 citations

Guidelines for the Evaluation of Immune Therapy Activity in Solid Tumors: Immune-Related Response Criteria

2009 • 3,044 citations

Cancer immunotherapy: moving beyond current vaccines

2004 • 2,932 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

Calreticulin exposure dictates the immunogenicity of cancer cell death

2006 • 2,789 citations

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

2002 • 2,781 citations

Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates

2010 • 2,721 citations

CTLA-4 Control over Foxp3 ⁺ Regulatory T Cell Function

2008 • 2,656 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

2011 • 2,257 citations

Ido expression by dendritic cells: tolerance and tryptophan catabolism

2004 • 2,235 citations

Dendritic Cells

2001 • 2,164 citations

Cytokine Storm in a Phase 1 Trial of the Anti-CD28 Monoclonal Antibody TGN1412

2006 • 2,010 citations

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

2010 • 1,779 citations

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 • 1,761 citations

Adoptive cell transfer: a clinical path to effective cancer immunotherapy

2008 • 1,560 citations

Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody–Cytotoxic Drug Conjugate

2008 • 1,545 citations

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

2011 • 1,515 citations

Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1

2011 • 1,511 citations

Programmed cell death 1 ligand 1 and tumor-infiltrating CD8⁺T lymphocytes are prognostic factors of human ovarian cancer

2007 • 1,317 citations

Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma

2006 • 1,254 citations

Role of LAG-3 in Regulatory T Cells

2004 • 1,198 citations

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

2011 • 1,191 citations

Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients

2006 • 1,180 citations

CELL BIOLOGY OF ANTIGEN PROCESSING IN VITRO AND IN VIVO

2005 • 1,108 citations

Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia

2009 • 1,027 citations

CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy

2001 • 964 citations

Overall Survival Analysis of a Phase II Randomized Controlled Trial of a Poxviral-Based PSA-Targeted Immunotherapy in Metastatic Castration-Resistant Prostate Cancer

2010 • 947 citations

A2A adenosine receptor protects tumors from antitumor T cells

2006 • 923 citations

Targeted Therapy With the T-Cell–Engaging Antibody Blinatumomab of Chemotherapy-Refractory Minimal Residual Disease in B-Lineage Acute Lymphoblastic Leukemia Patients Results in High Response Rate and Prolonged Leukemia-Free Survival

2011 • 855 citations

gp100 Peptide Vaccine and Interleukin-2 in Patients with Advanced Melanoma

2011 • 849 citations

Overexpression of PD-L1 Significantly Associates with Tumor Aggressiveness and Postoperative Recurrence in Human Hepatocellular Carcinoma

2009 • 770 citations

IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway

2009 • 769 citations

A listing of human tumor antigens recognized by T cells

2001 • 708 citations

Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients

2008 • 639 citations

HUMAN T CELL RESPONSES AGAINST MELANOMA

2005 • 638 citations

Immunotherapy of Hormone-Refractory Prostate Cancer With Antigen-Loaded Dendritic Cells

2000 • 627 citations

Antiangiogenic Agents Can Increase Lymphocyte Infiltration into Tumor and Enhance the Effectiveness of Adoptive Immunotherapy of Cancer

2010 • 610 citations

Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells

2008 • 597 citations

Phase II Clinical Trial of a Granulocyte-Macrophage Colony-Stimulating Factor–Encoding, Second-Generation Oncolytic Herpesvirus in Patients With Unresectable Metastatic Melanoma

2009 • 584 citations

Immune Therapy for Cancer

2008 • 581 citations

Prognostic Significance of Autoimmunity during Treatment of Melanoma with Interferon

2006 • 555 citations

Improved Endpoints for Cancer Immunotherapy Trials

2010 • 519 citations

Prognostic significance of autoimmunity during treatment of melanoma with interferon

2011 • 515 citations

Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy

2007 • 506 citations

A listing of human tumor antigens recognized by T cells: March 2004 update

2004 • 463 citations

Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu tolerized mice.

2001 • 454 citations

Herceptin: mechanisms of action and resistance

2005 • 429 citations

Epitope Landscape in Breast and Colorectal Cancer

2008 • 408 citations

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo

2009 • 394 citations

Disruption of E-Cadherin-Mediated Adhesion Induces a Functionally Distinct Pathway of Dendritic Cell Maturation

2007 • 348 citations

High-titer HER-2/neu protein-specific antibody can be detected in patients with early-stage breast cancer.

1997 • 347 citations

Designing Vaccines Based on Biology of Human Dendritic Cell Subsets

2010 • 320 citations

Negative Regulation of T Cell Homeostasis by Lymphocyte Activation Gene-3 (CD223)

2005 • 306 citations

PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice

2011 • 290 citations

CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers

2005 • 286 citations

IDO and tolerance to tumors

2003 • 262 citations

Principles of adoptive T cell cancer therapy

2007 • 260 citations

Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors

2006 • 257 citations

Agonist Anti-GITR Monoclonal Antibody Induces Melanoma Tumor Immunity in Mice by Altering Regulatory T Cell Stability and Intra-Tumor Accumulation

2010 • 249 citations

Timed Sequential Treatment With Cyclophosphamide, Doxorubicin, and an Allogeneic Granulocyte-Macrophage Colony-Stimulating Factor–Secreting Breast Tumor Vaccine: A Chemotherapy Dose-Ranging Factorial Study of Safety and Immune Activation

2009 • 225 citations

Overall survival and PD‐L1 expression in metastasized malignant melanoma

2010 • 220 citations

Augmented HER-2–Specific Immunity during Treatment with Trastuzumab and Chemotherapy

2007 • 206 citations

A Vascular Endothelial Growth Factor Receptor-2 Inhibitor Enhances Antitumor Immunity through an Immune-Based Mechanism

2007 • 198 citations

OX40 ligand shuts down IL-10-producing regulatory T cells

2006 • 193 citations

Effects of Vascular Endothelial Growth Factor on the Lymphocyte-Endothelium Interactions: Identification of Caveolin-1 and Nitric Oxide as Control Points of Endothelial Cell Anergy

2007 • 176 citations

Antigens for cancer immunotherapy

2008 • 166 citations

Final results of a multi-center, double-blind, randomized, placebo-controlled phase II study to assess the efficacy of MAGE-A3 immunotherapeutic as adjuvant therapy in stage IB/II non-small cell lung cancer (NSCLC)

2007 • 150 citations

Immunization with a P53 synthetic long peptide vaccine induces P53‐specific immune responses in ovarian cancer patients, a phase II trial

2009 • 139 citations

Placebo-Controlled Phase III Trial of Patient-Specific Immunotherapy With Mitumprotimut-T and Granulocyte-Macrophage Colony-Stimulating Factor After Rituximab in Patients With Follicular Lymphoma

2009 • 136 citations

IAP inhibitors enhance co-stimulation to promote tumor immunity

2010 • 132 citations

Dendritic cells in cancer immunotherapy

2010 • 113 citations

Cutting Edge: Rapamycin Augments Pathogen-Specific but Not Graft-Reactive CD8+ T Cell Responses

2010 • 113 citations

PD-1/PD-L1 pathway and T-cell exhaustion in chronic hepatitis virus infection

2010 • 91 citations

Towards patient‐specific tumor antigen selection for vaccination

2002 • 86 citations

Bacillus Calmette–Guérin treatment of non‐muscle invasive bladder cancer

2010 • 80 citations

Differential subcellular localization of the regulatory T‐cell protein LAG‐3 and the coreceptor CD4

2010 • 80 citations

HLA Class I Expression on Human Ovarian Carcinoma Cells Correlates with T-Cell Infiltrationin Vivoand T-Cell Expansionin Vitroin Low Concentrations of Recombinant Interleukin-2

1996 • 71 citations

A Commotion in the Blood: Life, Death, and the Immune System

1997 • 63 citations

Vascular endothelial growth factor-induced chemotaxis and IL-10 from T cells

2009 • 59 citations

Tumor-infiltrating lymphocytes: apparently good for melanoma patients. But why?

2011 • 57 citations

Whole-cell vaccines: A failure or a success waiting to happen?

2010 • 56 citations

Time-dependent cytotoxic drugs selectively cooperate with IL-18 for cancer chemo-immunotherapy

2011 • 47 citations

Regulatory T Cells

2010 • 41 citations

Clearance of hepatitis C in chimpanzees is associated with intrahepatic T-cell perforin expression during the late acute phase

2009 • 38 citations

Translational Research Working Group Developmental Pathway for Immune Response Modifiers

2008 • 36 citations