Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

Pathogen Recognition and Innate Immunity

2006 • 11,197 citations

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

2010 • 8,130 citations

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

Recognition of microorganisms and activation of the immune response

2007 • 2,700 citations

Innate immune recognition of viral infection

2006 • 1,790 citations

Immunity to fungal infections

2011 • 1,737 citations

Immune Signaling by RIG-I-like Receptors

2011 • 1,693 citations

The immune response of Drosophila

2003 • 1,463 citations

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

2011 • 1,440 citations

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

2008 • 1,280 citations

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

2008 • 1,268 citations

Intracellular Toll-like Receptors

2010 • 1,226 citations

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

2010 • 1,226 citations

Signalling through C-type lectin receptors: shaping immune responses

2009 • 1,223 citations

The SYK tyrosine kinase: a crucial player in diverse biological functions

2010 • 1,202 citations

Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

2004 • 1,109 citations

TLR3 Deficiency in Patients with Herpes Simplex Encephalitis

2007 • 1,082 citations

Cutting Edge: TLR2-Deficient and MyD88-Deficient Mice Are Highly Susceptible toStaphylococcus aureusInfection

2000 • 1,046 citations

TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein

2005 • 1,007 citations

Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

2004 • 946 citations

Toll-like receptor 3 promotes cross-priming to virus-infected cells

2005 • 902 citations

Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction

2005 • 886 citations

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

2009 • 869 citations

Autophagy-Dependent Viral Recognition by Plasmacytoid Dendritic Cells

2007 • 829 citations

TLRs and innate immunity

2008 • 800 citations

Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity

2006 • 794 citations

Pyogenic Bacterial Infections in Humans with IRAK-4 Deficiency

2003 • 789 citations

Toll-like receptor 2 controls expansion and function of regulatory T cells

2006 • 756 citations

A HomozygousCARD9Mutation in a Family with Susceptibility to Fungal Infections

2009 • 747 citations

Herpes Simplex Virus Encephalitis in Human UNC-93B Deficiency

2006 • 721 citations

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

2008 • 721 citations

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

2006 • 704 citations

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

2009 • 702 citations

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

2010 • 683 citations

A cell biological view of Toll-like receptor function: regulation through compartmentalization

2009 • 666 citations

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

2008 • 660 citations

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

2009 • 637 citations

Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin

2005 • 625 citations

Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant

2009 • 605 citations

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

2008 • 604 citations

Toll-Like Receptor 2 Suppresses Immunity against Candida albicans through Induction of IL-10 and Regulatory T Cells

2004 • 601 citations

Plasmacytoid Dendritic Cells: Recent Progress and Open Questions

2011 • 577 citations

Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling

2006 • 572 citations

An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

2009 • 551 citations

Toll‐like receptor expression in murine DC subsets: lack of TLR7 expression by CD8α⁺ DC correlates with unresponsiveness to imidazoquinolines

2003 • 544 citations

Nucleic Acid Recognition by the Innate Immune System

2011 • 541 citations

Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence

2009 • 516 citations

The Contribution of the Toll-Like/IL-1 Receptor Superfamily to Innate and Adaptive Immunity to Fungal Pathogens In Vivo

2004 • 500 citations

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

2009 • 489 citations

Detrimental Contribution of the Toll-Like Receptor (TLR)3 to Influenza A Virus–Induced Acute Pneumonia

2006 • 487 citations

Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate

2010 • 460 citations

Cutting Edge: Caspase-1 Independent IL-1β Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo

2010 • 445 citations

Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells

2006 • 436 citations

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

2009 • 430 citations

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling

2007 • 418 citations

Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

2009 • 378 citations

Alveolar Macrophages Are the Primary Interferon-α Producer in Pulmonary Infection with RNA Viruses

2007 • 374 citations

Myeloid C-type Lectin Receptors in Pathogen Recognition and Host Defense

2011 • 355 citations

Does Toll-like receptor 3 play a biological role in virus infections?

2004 • 354 citations

Regulation of the Antimicrobial Response by NLR Proteins

2011 • 347 citations

Human TLRs and IL-1Rs in Host Defense: Natural Insights from Evolutionary, Epidemiological, and Clinical Genetics

2011 • 345 citations

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

2009 • 342 citations

MyD88 Mediates Neutrophil Recruitment Initiated by IL-1R but Not TLR2 Activation in Immunity against Staphylococcus aureus

2006 • 338 citations

Toll-Like Receptor 3 Has a Protective Role against West Nile Virus Infection

2008 • 335 citations

Bifurcation of Toll-Like Receptor 9 Signaling by Adaptor Protein 3

2010 • 333 citations

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells

2009 • 329 citations

Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism

2006 • 323 citations

Human TRAF3 Adaptor Molecule Deficiency Leads to Impaired Toll-like Receptor 3 Response and Susceptibility to Herpes Simplex Encephalitis

2010 • 316 citations

Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria

2006 • 314 citations

IL-1 Receptor-Mediated Signal Is an Essential Component of MyD88-Dependent Innate Response to Mycobacterium tuberculosis Infection

2007 • 312 citations

Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination

2007 • 303 citations

Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRγ–Syk–Card9–dependent innate immune activation

2009 • 302 citations

Cutting Edge: TLR9 and TLR2 Signaling Together Account for MyD88-Dependent Control of Parasitemia in Trypanosoma cruzi Infection

2006 • 292 citations

The DNA Sugar Backbone 2′ Deoxyribose Determines Toll-like Receptor 9 Activation

2008 • 289 citations

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase

2011 • 286 citations

TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system

2007 • 285 citations

Cutting Edge: Candida albicans Hyphae Formation Triggers Activation of the Nlrp3 Inflammasome

2009 • 283 citations

Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses

2011 • 268 citations

Plasmacytoid dendritic cells sense hepatitis C virus–infected cells, produce interferon, and inhibit infection

2010 • 254 citations

Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing

2009 • 240 citations

Toll-Like Receptor 4 Contributes to Efficient Control of Infection with the Protozoan ParasiteLeishmania major

2004 • 238 citations

TLR Signaling Is Required for Salmonella typhimurium Virulence

2011 • 236 citations

Plasmodium bergheiInfection in Mice Induces Liver Injury by an IL-12- and Toll-Like Receptor/Myeloid Differentiation Factor 88-Dependent Mechanism

2001 • 220 citations

Reduced Numbers and Impaired Ability of Myeloid and Plasmacytoid Dendritic Cells to Polarize T Helper Cells in Chronic Hepatitis C Virus Infection

2004 • 213 citations

Toll-Like Receptors Are Temporally Involved in Host Defense

2004 • 210 citations

A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity

2008 • 209 citations

The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes

2010 • 201 citations

Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells

2011 • 201 citations

The adaptor molecule CARD9 is essential for tuberculosis control

2010 • 194 citations

TLR2 as an essential molecule for protective immunity against Toxoplasma gondii infection

2003 • 192 citations

Cutting Edge: Tlr5−/− Mice Are More Susceptible to Escherichia coli Urinary Tract Infection

2007 • 190 citations

Pure Hemozoin Is Inflammatory In Vivo and Activates the NALP3 Inflammasome via Release of Uric Acid

2009 • 177 citations

Granulin Is a Soluble Cofactor for Toll-like Receptor 9 Signaling

2011 • 169 citations

Vaccination of mice against invasive aspergillosis with recombinant Aspergillus proteins and CpG oligodeoxynucleotides as adjuvants

2002 • 162 citations

Involvement of the NLRP3 Inflammasome in Innate and Humoral Adaptive Immune Responses to Fungal β-Glucan

2009 • 160 citations

Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, ‐4 and ‐9

2008 • 159 citations

A Novel Toll-like Receptor That Recognizes Vesicular Stomatitis Virus

2010 • 159 citations

Pathological role of Toll-like receptor signaling in cerebral malaria

2006 • 156 citations

Immunogenicity of Whole-Parasite Vaccines against Plasmodium falciparum Involves Malarial Hemozoin and Host TLR9

2010 • 153 citations

Cutting Edge: Cooperation of IPS-1- and TRIF-Dependent Pathways in Poly IC-Enhanced Antibody Production and Cytotoxic T Cell Responses

2008 • 151 citations

Granuloma Formation and Host Defense in Chronic Mycobacterium tuberculosis Infection Requires PYCARD/ASC but Not NLRP3 or Caspase-1

2010 • 150 citations

Fungal Zymosan and Mannan Activate the Cryopyrin Inflammasome

2009 • 143 citations

Innate immune mechanisms for recognition and uptake of Candida species

2010 • 139 citations

TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88–independent TLR4 pathway

2009 • 133 citations

Plasmacytoid Dendritic Cells Delineate Immunogenicity of Influenza Vaccine Subtypes

2010 • 132 citations

TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin

2010 • 130 citations

Found in translation: the human equivalent of mouse CD8+ dendritic cells

2010 • 117 citations

UNC93B1 Is Essential for TLR11 Activation and IL-12-dependent Host Resistance to Toxoplasma gondii

2010 • 114 citations

Conventional Dendritic Cells Mount a Type I IFN Response againstCandidaspp. Requiring Novel Phagosomal TLR7-Mediated IFN-β Signaling

2011 • 111 citations

Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors

2010 • 110 citations

Induction and Evasion of Innate Antiviral Responses by Hepatitis C Virus

2010 • 105 citations

Cell culture-produced hepatitis C virus impairs plasmacytoid dendritic cell function

2007 • 105 citations

Intracellular Innate Immune Cascades and Interferon Defenses That Control Hepatitis C Virus

2009 • 104 citations

Fungal Recognition by TLR2 and Dectin-1

2007 • 103 citations

Nucleotide-Binding Oligomerization Domain Protein 2-Deficient Mice Control Infection with Mycobacterium tuberculosis

2007 • 103 citations

Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation

2010 • 99 citations

Malaria Parasites Require TLR9 Signaling for Immune Evasion by Activating Regulatory T Cells

2008 • 95 citations

MyD88 Signaling Is Indispensable for Primary Influenza A Virus Infection but Dispensable for Secondary Infection

2010 • 93 citations

The controversial relationship between NLRP3, alum, danger signals and the next‐generation adjuvants

2010 • 92 citations

Innate Immune Effectors in Mycobacterial Infection

2011 • 92 citations

TRIF Mediates Toll-like Receptor 5-induced Signaling in Intestinal Epithelial Cells

2010 • 91 citations

Recognition of yeast nucleic acids triggers a host‐protective type I interferon response

2011 • 88 citations

TLR5 functions as an endocytic receptor to enhance flagellin‐specific adaptive immunity

2010 • 87 citations

Regulatory molecules required for nucleotide‐sensing Toll‐like receptors

2008 • 79 citations

What is the role of Toll-like receptors in bacterial infections?

2007 • 78 citations

Regulatory role of Toll-like receptor 2 during infection with Trypanosoma cruzi

2004 • 71 citations

UNC93B1 Mediates Host Resistance to Infection with Toxoplasma gondii

2010 • 63 citations

Respective roles of TLR, RIG-I and NLRP3 in influenza virus infection and immunity: impact on vaccine design

2010 • 53 citations

The Role of Syk/CARD9-Coupled C-Type Lectin Receptors in Immunity toMycobacterium tuberculosisInfections

2010 • 48 citations

IL-1 receptor-associated kinase 1 mediates protection against Staphylococcus aureus infection

2004 • 42 citations

Deleted Work

1955 • 0 citations