Ncf1 (p47phox) Is Essential for Direct Regulatory T Cell Mediated Suppression of CD4+ Effector T Cells

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

1999 • 1,223 citations

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

2007 • 887 citations

Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

2007 • 871 citations

Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine

2009 • 836 citations

Regulatory T cells: how do they suppress immune responses?

2009 • 829 citations

IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells

2007 • 579 citations

T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells

2005 • 508 citations

The p47phox mouse knock-out model of chronic granulomatous disease.

1995 • 487 citations

Discrete Generation of Superoxide and Hydrogen Peroxide by T Cell Receptor Stimulation

2002 • 447 citations

Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance.

1996 • 444 citations

T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation

2004 • 441 citations

Positional identification of Ncf1 as a gene that regulates arthritis severity in rats

2002 • 381 citations

Distinct roles of CTLA‐4 and TGF‐β in CD4⁺CD25⁺ regulatory T cell function

2004 • 377 citations

Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis

2006 • 359 citations

Cellular and molecular basis for the regulation of inflammation by TGF-

2010 • 347 citations

Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene

2004 • 346 citations

X-linked lymphoreticular disease in the scurfy (sf) mutant mouse.

1991 • 339 citations

Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease

2002 • 332 citations

NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGF 1-induced fibroblast differentiation into myofibroblasts

2010 • 305 citations

NAD(P)H Oxidase Mediates TGF-β1–Induced Activation of Kidney Myofibroblasts

2009 • 282 citations

Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation☆

2006 • 249 citations

Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species

2010 • 237 citations

Membrane protein GARP is a receptor for latent TGF‐β on the surface of activated human Treg

2009 • 236 citations

T cell surface redox levels determine T cell reactivity and arthritis susceptibility

2006 • 235 citations

Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species

2007 • 234 citations

Human Anti-Inflammatory Macrophages Induce Foxp3+GITR+CD25+ Regulatory T Cells, Which Suppress via Membrane-Bound TGFβ-1

2008 • 233 citations

Immune dysregulation in TGF-beta 1-deficient mice.

1994 • 231 citations

Chronic granulomatous disease as a risk factor for autoimmune disease

2008 • 219 citations

The inhibition by diphenyleneiodonium and its analogues of superoxide generation by macrophages

1987 • 211 citations

Naturally occurring regulatory T cells show reduced sensitivity toward oxidative stress–induced cell death

2008 • 176 citations

Divided we stand: Tracking cell proliferation with carboxyfluorescein diacetate succinimidyl ester

1999 • 159 citations

Extracellular redox modulation by regulatory T cells

2009 • 139 citations

TGF-β-Mediated Suppression by CD4+CD25+ T Cells Is Facilitated by CTLA-4 Signaling

2006 • 134 citations

Hepatitis C Virus (HCV) Proteins Induce NADPH Oxidase 4 Expression in a Transforming Growth Factor β-Dependent Manner: a New Contributor to HCV-Induced Oxidative Stress

2009 • 127 citations

Regulatory T Cells Interfere with Glutathione Metabolism in Dendritic Cells and T Cells

2010 • 111 citations

P47phox-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and dbl+

2000 • 100 citations

N-acetylcysteine inhibits alveolar epithelial-mesenchymal transition

2009 • 94 citations

Deficiency of NADPH Oxidase Components p47phox and gp91phox Caused Granulomatous Synovitis and Increased Connective Tissue Destruction in Experimental Arthritis Models

2003 • 93 citations

The Role of Low Molecular Weight Thiols in T Lymphocyte Proliferation and IL-2 Secretion

2005 • 86 citations

Endogenous TGF-β activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25-T cells

2007 • 85 citations

T cell receptor-stimulated generation of hydrogen peroxide inhibits MEK-ERK activation and lck serine phosphorylation

2003 • 79 citations

Antigen-presenting cells control T cell proliferation by regulating amino acid availability

2002 • 71 citations

N-Acetyl-l-cysteine suppresses TGF-β signaling at distinct molecular steps: The biochemical and biological efficacy of a multifunctional, antifibrotic drug

2005 • 60 citations

Gastrointestinal manifestations of chronic granulomatous disease

2006 • 59 citations

Ncf1-Associated Reduced Oxidative Burst Promotes IL-33R+ T Cell-Mediated Adjuvant-Free Arthritis in Mice

2009 • 30 citations

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