Internal hazards: baseline DNA damage by endogenous products of normal metabolism

The Metabolic and Molecular Bases of Inherited Disease

1995 • 12,086 citations

The Free Radical Theory of Aging Matures

1998 • 3,846 citations

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

1981 • 3,794 citations

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

1983 • 3,602 citations

Casarett and Doull's Toxicology: The Basic Science of Poisons

1992 • 3,276 citations

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

1997 • 1,762 citations

Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster

1994 • 1,461 citations

Glucose autoxidation and protein modification. The potential role of ‘autoxidative glycosylation’ in diabetes

1987 • 1,278 citations

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

1991 • 1,223 citations

Molecular basis of base substitution hotspots in Escherichia coli

1978 • 1,185 citations

DNA damage and mutation in human cells exposed to nitric oxide in vitro.

1992 • 980 citations

Functional role of estrogen metabolism in target cells: review and perspectives

1998 • 965 citations

Cancer risk and oxidative DNA damage in man

1996 • 936 citations

DNA glycosylases in the base excision repair of DNA

1997 • 840 citations

Oxidative DNA Damage in the Parkinsonian Brain: An Apparent Selective Increase in 8‐Hydroxyguanine Levels in Substantia Nigra

1997 • 822 citations

Hydroxyl radical production and autoxidative glycosylation. Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing

1988 • 787 citations

The Advanced Glycation End Product, N∊-(Carboxymethyl)lysine, Is a Product of both Lipid Peroxidation and Glycoxidation Reactions

1996 • 780 citations

Mutagenic deamination of cytosine residues in DNA

1980 • 761 citations

Molecular origin of cancer: Catechol estrogen-3,4-quinones as endogenous tumor initiators

1997 • 731 citations

Aging and resistance to oxidative damage in Caenorhabditis elegans.

1993 • 720 citations

DNA oxidation matters: The HPLC–electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine

1998 • 694 citations

The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)

1992 • 688 citations

Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome

1990 • 687 citations

The multifaceted roles of nitric oxide in cancer

1998 • 686 citations

Molecular Mechanisms of Estrogen Carcinogenesis

1996 • 659 citations

Naturally occurring carbonyl compounds are mutagens Salmonella tester strain TA104

1985 • 596 citations

Identification of Glyoxal and Arabinose as Intermediates in the Autoxidative Modification of Proteins by Glucose

1995 • 584 citations

[3] Free radical initiators as source of water- or lipid-soluble peroxyl radicals

1990 • 562 citations

Mechanisms of carcinogenesis induced by alkylating agents

1985 • 461 citations

Lethal oxidative damage and mutagenesis are generated by iron in delta fur mutants of Escherichia coli: protective role of superoxide dismutase

1995 • 438 citations

4-Hydroxylation of estrogens as marker of human mammary tumors.

1996 • 411 citations

Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction.

1982 • 398 citations

Exogenous advanced glycosylation end products induce complex vascular dysfunction in normal animals: a model for diabetic and aging complications.

1992 • 378 citations

Detection of Endogenous Malondialdehyde-Deoxyguanosine Adducts in Human Liver

1994 • 368 citations

Toward the Primary Prevention of Cancer

1991 • 361 citations

Carcinogenicity of catechol estrogens in Syrian hamsters

1986 • 360 citations

Free Radical-Mediated Lipid Peroxidation in Cells: Oxidizability Is a Function of Cell Lipid bis-Allylic Hydrogen Content

1994 • 350 citations

Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts

1996 • 345 citations

Formation of 8‐nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination

1995 • 343 citations

Functional cooperation of MutT, MutM and MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli

1995 • 332 citations

Uterine adenocarcinoma in mice following developmental treatment with estrogens: a model for hormonal carcinogenesis.

1990 • 314 citations

Oxygen-dependent mutagenesis in Escherichia coli lacking superoxide dismutase.

1986 • 314 citations

Glutathione-dependent detoxification of α-oxoaldehydes by the glyoxalase system: involvement in disease mechanisms and antiproliferative activity of glyoxalase I inhibitors

1998 • 309 citations

Oxidized, deaminated cytosines are a source of C → T transitions in vivo

1998 • 297 citations

Formation of 8-nitroguanine by the reaction of guanine with peroxynitrite in vitro

1995 • 289 citations

Quantification of malondialdehyde and 4-hydroxynonenal adducts to lysine residues in native and oxidized human low-density lipoprotein

1997 • 288 citations

An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer.

1997 • 286 citations

Endogenous DNA adducts: Potential and paradox

1993 • 284 citations

The occurrence of hepatoma in the chronic form of hereditary tyrosinemia

1976 • 282 citations

Endogenous oxidative damage of deoxycytidine in DNA.

1992 • 280 citations

Nitric Oxide Regulation of Tissue Free Radical Injury

1996 • 278 citations

DNA base modifications in chromatin of human cancerous tissues

1992 • 278 citations

Oxidation of High Density Lipoproteins

1998 • 273 citations

Genotoxic lipid peroxidation products: their DNA damaging properties and role in formation of endogenous DNA adducts

1998 • 267 citations

Mechanisms of hypochlorite injury of target cells.

1990 • 261 citations

Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer

1994 • 243 citations

Repair of DNA containing O ⁶ ‐alkylguanine

1992 • 241 citations

Simultaneous Overexpression of Copper- and Zinc-containing Superoxide Dismutase and Catalase Retards Age-related Oxidative Damage and Increases Metabolic Potential in Drosophila melanogaster

1995 • 239 citations

Mutagenic spectrum resulting from DNA damage by oxygen radicals

1991 • 237 citations

Assay of Aldehydes from Lipid Peroxidation: Gas Chromatography–Mass Spectrometry Compared to Thiobarbituric Acid

1997 • 228 citations

The role of nitric oxide (NO·) in the carcinogenic process

1996 • 225 citations

Formation of 1,N6-Ethenoadenine and 3,N4-Ethenocytosine by Lipid Peroxidation Products and Nucleic Acid Bases

1995 • 220 citations

Detection of exocyclic 1,N2-propanodeoxyguanosine adducts as common DNA lesions in rodents and humans.

1994 • 217 citations

1,N⁶-Ethenodeoxyadenosine and 3,N⁴-ethenodeoxycytidine in liver DNA from humans and untreated rodents detected by immunoaffinity/³²P-postlabelling

1995 • 212 citations

Peroxynitrite-induced mutation spectra of pSP189 following replication in bacteria and in human cells

1996 • 212 citations

Modification of DNA by reducing sugars: a possible mechanism for nucleic acid aging and age-related dysfunction in gene expression.

1984 • 211 citations

Estradiol 16 alpha-hydroxylation in the mouse correlates with mammary tumor incidence and presence of murine mammary tumor virus: a possible model for the hormonal etiology of breast cancer in humans.

1985 • 210 citations

Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies.

1989 • 204 citations

Determination of 8-Oxoguanine in DNA by Gas Chromatography-Mass Spectrometry and HPLC-Electrochemical Detection: Overestimation of the Background Level of the Oxidized Base by the Gas Chromatography-Mass Spectrometry Assay

1995 • 204 citations

Mutagenic potency of exocyclic DNA adducts: marked differences between Escherichia coli and simian kidney cells.

1994 • 202 citations

Molecular Characteristics of Catechol Estrogen Quinones in Reactions with Deoxyribonucleosides

1996 • 200 citations

Mutation spectrum of copper-induced DNA damage.

1991 • 190 citations

Reverse chemical mutagenesis: identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA.

1994 • 189 citations

Problems in the measurement of 8-oxoguanine in human DNA. Report of a workshop, DNA oxidation, held in Aberdeen, UK, 19-21 January, 1997

1997 • 189 citations

Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferase

1991 • 187 citations

Mitochondrial mutational spectra in human cells and tissues

1997 • 181 citations

1,N⁶-Ethenodeoxyadenosine, a DNA Adduct Highly Mutagenic in Mammalian Cells

1996 • 178 citations

In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells.

1993 • 177 citations

Nitric Oxide-induced Deamination of Cytosine and Guanine in Deoxynucleosides and Oligonucleotides

1998 • 176 citations

Induction of Apoptotic Cell Death by Methylglyoxal and 3-Deoxyglucosone in Macrophage-Derived Cell Lines

1996 • 175 citations

Indirect mutagenesis by oxidative DNA damage: Formation of the pyrimidopurinone adduct of deoxyguanosine by base propenal

1998 • 175 citations

Peroxynitrite Mediated Oxidation of Purine Bases of Nucleosides and Isolated DNA

1996 • 174 citations

Effects of carbon dioxide/bicarbonate on induction of DNA single‐strand breaks and formation of 8‐nitroguanine, 8‐oxoguanine and base‐propenal mediated by peroxynitrite

1996 • 168 citations

Formation, Detection, and Role In Carcinogenesis of Ethenobases in Dna

1994 • 167 citations

Genotoxic properties of 4-hydroxyalkenals and analogous aldehydes

1993 • 166 citations

New biomarkers of Maillard reaction damage to proteins

1996 • 164 citations

Quantitation of 8-Oxoguanine and Strand Breaks Produced by Four Oxidizing Agents

1997 • 163 citations

Age-related changes in lipid peroxidation as measured by ethane, ethylene, butane and pentane in respired gases of rats

1980 • 162 citations

Hypochlorous Acid-Induced Base Modifications in Isolated Calf Thymus DNA

1997 • 161 citations

Effects of aminoguanidine in preventing experimental diabetic nephropathy are related to the duration of treatment

1996 • 160 citations

Identification of N2-(1-Carboxyethyl)guanine (CEG) as a Guanine Advanced Glycosylation End Product

1995 • 158 citations

Pathways of Formation of Glycoxidation Products during Glycation of Collagen

1995 • 158 citations

Base Modification and Strand Breakage in Isolated Calf Thymus DNA and in DNA from Human Skin Epidermal Keratinocytes Exposed to Peroxynitrite or 3-Morpholinosydnonimine

1996 • 156 citations

Generation of an endogenous DNA-methylating agent by nitrosation in Escherichia coli

1996 • 155 citations

Free radical generation during δ-Aminolevulinic acid autoxidation: Induction by hemoglobin and connections with porphyrinpathies

1989 • 150 citations

Mutagenicity in Escherichia coli of the major DNA adduct derived from the endogenous mutagen malondialdehyde

1997 • 149 citations

Assay of Malondialdehyde in Biological Fluids by Gas Chromatography-Mass Spectrometry

1994 • 149 citations

Escherichia coli mutants deficient in 3-methyladenine-DNA glycosylase

1980 • 146 citations

Imidazolium crosslinks derived from reaction of lysine with glyoxal and methylglyoxal are increased in serum proteins of uremic patients: evidence for increased oxidative stress in uremia

1998 • 142 citations

Induction of liver tumors in F344 rats by crotonaldehyde.

1986 • 140 citations

Acrolein initiates rat urinary bladder carcinogenesis.

1992 • 138 citations

Artifacts associated with the measurement of oxidized DNA bases.

1997 • 138 citations

New Role for Estrogen in Cancer?

1998 • 138 citations

Synthesis and characterization of estrogen 2,3- and 3,4-quinones. Comparison of DNA adducts formed by the quinones versus horseradish peroxidase-activated catechol estrogens

1992 • 134 citations

Detection and identification of mutagens and carcinogens as their adducts with guanosine derivatives

1984 • 134 citations

Molecular dosimetry of ethylene oxide: formation and persistence of N-(2-hydroxyethyl)valine in hemoglobin following repeated exposures of rats and mice.

1992 • 133 citations

Estrogen-induced endogenous DNA adduction: possible mechanism of hormonal cancer.

1986 • 132 citations

Comparison of the mutagenicities of malondialdehyde and the side products formed during its chemical synthesis.

1980 • 132 citations

Microsome-mediated 8-hydroxylation of guanine bases of DNA by steroid estrogens: correlation of DNA damage by free radicals with metabolic activation to quinones

1995 • 131 citations

Activation of Endogenous Antioxidant Defenses in Neuronal Cells Prevents Free Radical‐Mediated Damage

1998 • 131 citations

8-Hydroxylation of guanine bases in kidney and liver DNA of hamsters treated with estradiol: role of free radicals in estrogen-induced carcinogenesis.

1994 • 130 citations

Mutagenicity and cytotoxicity of malonaldehyde in mammalian cells

1979 • 129 citations

1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal.

1988 • 129 citations

1,N2-propanodeoxyguanosine adducts: potential new biomarkers of smoking-induced DNA damage in human oral tissue.

1998 • 126 citations

Acute hepatic porphyria and hepatocellular carcinoma

1988 • 126 citations

A Chemical and Genetic Approach Together Define the Biological Consequences of 3-Methyladenine Lesions in the Mammalian Genome

1998 • 126 citations

Detection of 1, N2-propanodeoxyguanosine adducts as potential endogenous DNA lesions in rodent and human tissues.

1996 • 124 citations

Quantitative Measurement of Radiation-Induced Base Products in DNA Using Gas Chromatography-Mass Spectrometry

1989 • 123 citations

Mutagenicity of Glutathione and Cysteine in the Ames Test

1983 • 122 citations

Detection of 3-deoxyfructose and 3-deoxyglucosone in human urine and plasma: Evidence for intermediate stages of the maillard reaction in vivo

1992 • 115 citations

The Mutagenicity of the Tyrosine Metabolite, Fumarylacetoacetate, Is Enhanced by Glutathione Depletion

1997 • 114 citations

DNA single-strand breaks in kidneys of Syrian hamsters treated with steroidal estrogens: hormone-induced free radical damage preceding renal malignancy

1994 • 114 citations

The 1995 Walter Hubert Lecture - molecular epidemiology of human cancer: insights from the mutational analysis of the p53 tumour-suppressor gene

1996 • 111 citations

Analysis of the Malondialdehyde−2‘- Deoxyguanosine Adduct Pyrimidopurinone in Human Leukocyte DNA by Gas Chromatography/Electron Capture/Negative Chemical Ionization/Mass Spectrometry

1997 • 110 citations

What Structural Features Determine Repair Enzyme Specificity and Mechanism in Chemically Modified DNA?

1997 • 109 citations

Quercetin Increases the Severity of Estradiol-Induced Tumorigenesis in Hamster Kidney

1994 • 108 citations

Bicarbonate Inhibits N-Nitrosation in Oxygenated Nitric Oxide Solutions

1996 • 108 citations

Generation of active oxygen species during coupled autoxidation of oxyhemoglobin and δ-aminolevulinic acid

1986 • 106 citations

Comparison of DNA adduct levels associated with oxidative stress in human pancreas

1998 • 103 citations

Relative contributions of advanced glycation and nitric oxide synthase inhibition to aminoguanidine-mediated renoprotection in diabetic rats

1997 • 102 citations

Artifacts Associated with the Measurement of Oxidized DNA Bases

1997 • 100 citations

Measurement of oxidative DNA damage by gas chromatography–mass spectrometry: ethanethiol prevents artifactual generation of oxidized DNA bases

1998 • 99 citations

Recognition of oxidized abasic sites by repair endonucleases

1994 • 99 citations

Stereoselective formation of in vitro nucleic acid adducts by 2,3-epoxy-4-hydroxynonanal.

1991 • 97 citations

Nitrosated glycine derivatives as a potential source of O6-methylguanine in DNA.

1997 • 96 citations

Detection of DNA modifications by the 32P-postlabelling assay

1997 • 94 citations

Copper-dependent formation of miscoding etheno-DNA adducts in the liver of Long Evans cinnamon (LEC) rats developing hereditary hepatitis and hepatocellular carcinoma.

1996 • 93 citations

Induction of cell cycle arrest by the endogenous product of lipid peroxidation, malondialdehyde

1998 • 91 citations

DNA Sequence Changes Induced by Two Nitric Oxide Donor Drugs in the supF Assay

1994 • 85 citations

Modification of DNA by glucose 6-phosphate induces DNA rearrangements in an Escherichia coli plasmid.

1985 • 85 citations

Toxicological Significance of DNA Adducts: Summary of Discussions with an Expert Panel

1996 • 84 citations

5-Aminolevulinic Acid Induces Iron Release from Ferritin

1995 • 84 citations

Smoking-related DNA adducts: ³²P-postlabeling analysis of 7-methylguanine in human bronchial and lymphocyte DNA

1993 • 82 citations

Induction of a Wide Range of C2–12 Aldehydes and C7–12 Acyloins in the Kidney of Wistar Rats After Treatment With a Renal Carcinogen, Ferric Nitrilotriacetate

1997 • 81 citations

Mapping frequencies of endogenous oxidative damage and the kinetic response to oxidative stress in a region of rat mtDNA

1997 • 80 citations

Formation of DNA adducts in human buccal epithelial cells exposed to acetaldehyde and methylglyoxal in vitro

1998 • 80 citations

Nitrosated peptides and polyamines as endogenous mutagens in O6- alkylguanine-DNA alkyltransferase deficient cells

1997 • 79 citations

Glyoxal, a major product of DNA oxidation, induces mutations at G:C sites on a shuttle vector plasmid replicated in mammalian cells

1997 • 76 citations

Epoxidation of trans-4-Hydroxy-2-nonenal by Fatty Acid Hydroperoxides and Hydrogen Peroxide

1996 • 71 citations

The spectrum of mutations generated by passage of a hydrogen peroxide damaged shuttle vector plasmid through a mammalian host

1989 • 69 citations

Misincorporation of Nucleotides opposite Five-Membered Exocyclic Ring Guanine Derivatives by Escherichia coli Polymerases in Vitro and in Vivo: 1,N²-Ethenoguanine, 5,6,7,9-Tetrahydro-9-oxoimidazo[1,2-a]purine, and 5,6,7,9-Tetrahydro-7-hydroxy-9-oxoimidazo[1,2-a]purine

1998 • 67 citations

³²P-Postlabelling determination of DNA adducts of malonadlehyde in humans: total white blood cells and breast tissue

1995 • 67 citations

Mutagenicity of sodium hypochlorite for Salmonella typhimurium

1975 • 65 citations

DNA Alkylation by 4,5-Dioxovaleric Acid, the Final Oxidation Product of 5-Aminolevulinic Acid

1998 • 65 citations

Formation of Etheno Adducts in Reactions of Enals via Autoxidation

1994 • 63 citations

Mechanisms of mutagenesis by exocyclic DNA adducts. Transfection of M13 viral DNA bearing a site-specific adduct shows that ethenocytosine is a highly efficient RecA-independent mutagenic noninstructional lesion

1991 • 63 citations

[55] Selected-ion mass spectrometry: Assays of oxidative DNA damage

1990 • 62 citations

Substitution and deletion mutations induced by 2-hydroxyadenine in Escherichia coli: effects of sequence contexts in leading and lagging strands

1997 • 61 citations

Development of a ³²P-postlabelling method for the analysis of 2'-deoxyguanosine-3'-monophosphate and DNA adducts of methylglyoxal

1994 • 61 citations

Superoxide dismutase (sod-1) null mutants of Neurospora crassa: oxidative stress sensitivity, spontaneous mutation rate and response to mutagens.

1994 • 59 citations

Mechanisms of DNA damage by chromium(V) carcinogens

1998 • 59 citations

Mutations Induced by 2-Hydroxyadenine on a Shuttle Vector during Leading and Lagging Strand Syntheses in Mammalian Cells

1997 • 59 citations

5-Aminolevulinic acid mediates the in vivo and in vitro formation of 8-hydroxy-2'-deoxyguanosine in DNA

1994 • 57 citations

Cigarette Smoking and Urinary 3-Alkyladenine Excretion in Man

1996 • 55 citations

The Prevention of Cancer

1998 • 53 citations

Detection of O⁶-methylguanine, O⁴-methylthymine and O⁴-ethylthymine in human liver and peripheral blood leukocyte DNA

1995 • 53 citations

Site-specific mutagenesis by a propanodeoxyguanosine adduct carried on an M13 genome.

1994 • 53 citations

Combined high-performance liquid chromatography/32P-postlabeling assay of N7-methyldeoxyguanosine.

1990 • 52 citations

Genotoxic effects of the α, β-unsaturated aldehydes 2-trans-butenal,2-trans-hexenal and 2-trans, 6-cis-rmnonadienal

1995 • 51 citations

Does δ-aminolaevulinic acid induce genotoxic effects?

1996 • 50 citations

5-Aminolevulinic acid induces single-strand breaks in plasmid pBR322 DNA in the presence of Fe2+ ions

1994 • 50 citations

Mechanism of oxidative DNA damage induced by delta-aminolevulinic acid in the presence of copper ion.

1996 • 50 citations

Intrachromosomal Probes for Mutagenesis by Alkylated DNA Bases Replicated in Mammalian Cells: A Comparison of the Mutagenicities of O⁴-Methylthymine and O⁶-Methylguanine in Cells with Different DNA Repair Backgrounds

1996 • 50 citations

Toxicokinetics of isoprene in rodents and humans

1996 • 50 citations

Determination of the lipid peroxidation product (E)-4-hydroxy-2-nonenal in clinical samples by gas chromatography-negative-ion chemical ionisation mass spectrometry of the O-pnetafluorobenzyl oxime

1997 • 48 citations

A contribution to the study of the structure-mutagenicity relationship for α-dicarbonyl compounds using the Ames test

1992 • 48 citations

Formation of a mutagen, glyoxal, from DNA treated with oxygen free radicals

1995 • 47 citations

(E)-2-Hexenal-Induced DNA Damage and Formation of Cyclic 1,N²-(1,3-Propano)-2‘-deoxyguanosine Adducts in Mammalian Cells

1996 • 47 citations

Quantification of endogenous carcinogens

1996 • 47 citations

Synthesis and ³²P-Postlabeling/High-Performance Liquid Chromatography Separation of Diastereomeric 1,N²-(1,3-Propano)-2‘-deoxyguanosine 3‘-Phosphate Adducts Formed from 4-Hydroxy-2-nonenal

1997 • 47 citations

Peroxy Radical Oxidation of Thymidine

1997 • 45 citations

Mitochondrial DNA in β-Cells Is a Sensitive Target for Damage by Nitric Oxide

1997 • 45 citations

Synthesis, Characterization, and Immunochemical Detection of O⁶-(Carboxymethyl)-2‘-deoxyguanosine: A DNA Adduct Formed by Nitrosated Glycine Derivatives

1997 • 44 citations

The Nature of Reactive Species in Systems That Produce Peroxynitrite

1998 • 42 citations

Genotoxic effects of 2-trans-hexenal in human buccal mucosa cells in vivo

1997 • 41 citations

A spectrum of mutations induced by crotonaldehyde in shuttle vector plasmids propagated in human cells

1998 • 41 citations

Comparative analysis of 8-oxo-2' -deoxyguanosine in DNA by 32P- and 33P- postlabeling and electrochemical detection

1997 • 41 citations

In vivo aging of rat skeletal muscle sarcoplasmic reticulum Ca-ATPase. Chemical analysis and quantitative simulation by exposure to low levels of peroxyl radicals

1997 • 39 citations

Volatile metabolites in sera of normal and diabetic patients

1980 • 39 citations

Enhancement of estrogen-induced renal tumorigenesis in hamsters by dietary iron

1998 • 39 citations

The in Vitro Methylation of DNA by a Minor Groove Binding Methyl Sulfonate Ester

1996 • 38 citations

Dietary· supplements of antioxidants reduce hprt mutant frequency in splenocytes of aging mice

1995 • 38 citations

Reduction of the Toxicity and Mutagenicity of Aziridine in Mammalian Cells Harboring the Escherichia Coli fpg Gene

1996 • 37 citations

High-Performance Liquid Chromatography/Electrospray Mass Spectrometry for the Analysis of Modified Bases in DNA: 7-(2-Hydroxyethyl)Guanine, the Major Ethylene Oxide−DNA Adduct

1997 • 36 citations

[32P]ATP mediates formation of 8-hydroxy-2'-deoxyguanosine from 2'- deoxyguanosine, a possible problem in the 32P-postlabeling assay

1997 • 35 citations

Mutagenesis by Peroxy Radical Is Dominated by Transversions at Deoxyguanosine: Evidence for the Lack of Involvement of 8-oxo-dG¹ and/or Abasic Site Formation

1998 • 34 citations

Comparison of mutagenesis by O6-methyl- and O6-ethylguanine and O4- methylthymine in Escherichia coli using double-stranded and gapped plasmids

1998 • 33 citations

Identification and characterization of deoxyguanosine adducts of mutagenic .beta.-alkyl-substituted acrolein congeners

1993 • 33 citations

Mutation Induced by Deoxyxanthosine in Codon 12 of A Synthetic c-Ha-ras Gene

1992 • 31 citations

Mutagenesis in Escherichia coli lacking catalase

1990 • 31 citations

Oxidative DNA damage induced by homogentisic acid, a tyrosine metabolite

1998 • 30 citations

Types of mutations induced by glyoxal, a major oxidative DNA-damage product, in Salmonella typhimurium

1997 • 30 citations

Endogenous mutagens derived from amino acids

1990 • 28 citations

Measurement of 5-aminolaevulinic acid by reversed phase HPLC and fluorescence detection

1986 • 28 citations

Direct detection of radical generation in rat liver nuclei on treatment with tumour-promoting hydroperoxides and related compounds

1994 • 27 citations

The influence of DNA glycosylases on spontaneous mutation

1998 • 27 citations

Endogenous Production of DNA Adducts

1996 • 27 citations

Mutations Induced in the supF Gene of pSP189 by Hydroxyl Radical and Singlet Oxygen: Relevance to Peroxynitrite Mutagenesis

1998 • 26 citations

Modification of the Amino Group of Guanosine by Methylglyoxal and Other .ALPHA.-Ketoaldehydes in the Presence of Hydrogen Peroxide.

1993 • 26 citations

Estrogen-nucleic acid adducts: guanine is major site for interaction between 3,4-estrone quinone and COIII gene

1997 • 25 citations

Validation of Malondialdehyde and 4-Hydroxy-2-trans-Nonenal Measurement in Plasma by NICI-GC-MS

1998 • 25 citations

Selectivity of Alkylation and Aralkylation of Nucleic Acid Components

1982 • 23 citations

Estrogen−Nucleic Acid Adducts: Reaction of 3,4-Estrone o-Quinone with Nucleic Acid Bases

1997 • 21 citations

Quantitation of homogentisic acid in normal human plasma

1996 • 20 citations

Measurement of copper-dependent oxidative DNA damage by HOCl and H2O2 with the ethidium-binding assay

1996 • 19 citations

Mutations at G:C base pairs predominate after replication of peroxyl radical-damaged pSP189 plasmids in human cells

1999 • 16 citations

Peroxynitrite Uncloaked?

1998 • 16 citations

Formation of Novel C1-Oxidised Abasic Sites in Alkylperoxyl Radical-Damaged Plasmid DNA

1997 • 15 citations

Methylglyoxal Production in Human Blood

1979 • 15 citations

Molecular spectrum of mutations induced by 5-hydroxymethyl-2′-deoxyuridine in (CHO)-PL61 cells

1997 • 14 citations

Formation of Carbonyls during Attack on Insulin by Submolar Amounts of Hypochlorite

1998 • 14 citations

Mitochondrial DNA in beta-cells is a sensitive target for damage by nitric oxide

1997 • 14 citations

Role of G→T Transversions in the Mutagenicity of Alkylperoxyl Radicals: Induction of Alkali-Labile Sites in Bacteriophage M13mp19

1997 • 11 citations

Mutagenic Specificity of Model Estrogen−DNA Adducts in Mammalian Cells

1998 • 11 citations

Mutagenic frequencies of site-specifically located O6-methylguanine in wild-type Escherichia coli and in a strain deficient in ada-methyltransferase

1991 • 10 citations

Position- and base pair-specific comparison of p53 mutation spectra in human tumors: elucidation of relationships between organs for cancer etiology.

1998 • 7 citations

Miscoding Properties of Model Estrogen−DNA Adducts in Reactions Catalyzed by Mammalian and Escherichia coli DNA Polymerases^,

1997 • 6 citations

Reaction of Adenine with 6-Hydroxyestrogen 6-Sulfates: Model Compounds to Demonstrate Carcinogenesis by Estrogen.

1996 • 4 citations