Comparison of mutagenesis by O6-methyl- and O6-ethylguanine and O4- methylthymine in Escherichia coli using double-stranded and gapped plasmids

In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome.

1984 • 437 citations

Site-specifically modified oligodeoxynucleotides as probes for the structural and biological effects of DNA-damaging agents

1988 • 177 citations

O-alkyl pyrimidines in mutagenesis and carcinogenesis: occurrence and significance.

1986 • 153 citations

Site-specific mutagenesis: retrospective and prospective

1991 • 149 citations

Mutagenic potential of O4-methylthymine in vivo determined by an enzymatic approach to site-specific mutagenesis.

1986 • 143 citations

Site-specific mutagenesis in vivo by single methylated or deaminated purine bases

1986 • 118 citations

THE OCCURRENCE OF A GENETIC TRANSPOSITION IN A STRAIN OF ESCHERICHIA COLI

1962 • 113 citations

Purification of theE.coliogt gene product to homogeneity and its rate of action onO⁶-methylguanine,O⁶-ethyiguanine andO⁴-methylthymine in dodecadeoxyribnucleotides

1989 • 81 citations

The in vivo mutagenic frequency and specificity of O6-methylguanine in phi X174 replicative form DNA.

1986 • 76 citations

Repair of O⁶-methylguanine, O⁶-ethylguanine, O⁶-isopropylguanine, and O⁴-methylthymine in synthetic oligodeoxynucleotides by Escherichia coli ada gene O⁶-alkylguanine-DNA-alkyltransferase

1989 • 71 citations

Specific strand loss in N-2-acetylaminofluorene-modified DNA

1987 • 66 citations

uvrA and recA mutations inhibit a site-specific transition produced by a single O6-methylguanine in gene G of bacteriophage phi X174.

1985 • 58 citations

Comparison of the relative mutagenicities of O-alkylthymines site-specifically incorporated into phi X174 DNA.

1987 • 55 citations

Comparative mutagenesis of O6-methylguanine and O4-methylthymine in Escherichia coli

1991 • 51 citations

Excision repair of O⁶-methylguanine synthesized at the rat H-ras N-methyl-N-nitrosourea activation site and introduced into Escherichia coli

1989 • 47 citations

Response of Repair-Competent and Repair-Deficient Escherichia coli to Three O6-Substituted Guanines and Involvement of Methyl-Directed Mismatch Repair in the Processing of O6-Methylguanine Residues

1994 • 38 citations

Synthesis and properties of H-ras DNA sequences containing O6-substituted 2'-deoxyguanosine residues at the first, second, or both positions of codon 12

1988 • 30 citations

Mutagenesis in Escherichia coli by Three O6-Substituted Guanines in Double-Stranded or Gapped Plasmids

1995 • 27 citations

In vivo effect of DNA repair on the transition frequency produced from a single O6-methyl-or O6-n-butyl-guanine in a T:G base pair

1988 • 19 citations

A sectored colony assay for monitoring mutagenesis by specific carcinogen-DNA adducts in Escherichia coli

1991 • 13 citations

Site-specific mutagenesis in cells with normal DNA repair systems: transitions produced from DNA carrying a single O6-alkylguanine

1991 • 12 citations

Mutagenic frequencies of site-specifically located O6-methylguanine in wild-type Escherichia coli and in a strain deficient in ada-methyltransferase

1991 • 10 citations

Site-directed mutagenesis in single cells: Transitions produced by DNA carrying a single O6-alkylguanine residue

1993 • 5 citations

Workshop report from the Division of Research Grants, National Institutes of Health. Site-specific mutagenesis--a Chemical Pathology Study Section Workshop.

1989 • 4 citations