Oxidized, deaminated cytosines are a source of C → T transitions in vivo

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

[2] New M13 vectors for cloning

1983 • 5,402 citations

DNA cloning : a practical approach

1985 • 2,302 citations

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

1991 • 2,172 citations

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

1992 • 1,830 citations

Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome

1990 • 687 citations

Persistence of O 6-Ethylguanine in Rat-Brain DNA: Correlation with Nervous System-Specific Carcinogenesis by Ethylnitrosourea

1974 • 495 citations

New substrates for old enzymes. 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2'-deoxyuridine is a substrate for uracil DNA N-glycosylase.

1994 • 337 citations

Mechanisms of spontaneous mutagenesis: An analysis of the spectrum of spontaneous mutation in the Escherichia coli lacI gene

1986 • 305 citations

Genetic studies of the lac repressor

1977 • 293 citations

Endogenous oxidative damage of deoxycytidine in DNA.

1992 • 280 citations

Substrate specificity of the Escherichia coli endonuclease III: Excision of thymine- and cytosine-derived lesions in DNA produced by radiation-generated free radicals

1993 • 277 citations

Repair of products of oxidative DNA base damage in human cells

1996 • 269 citations

The thymine-thymine pyrimidine-pyrimidone(6-4) ultraviolet light photoproduct is highly mutagenic and specifically induces 3' thymine-to-cytosine transitions in Escherichia coli.

1991 • 208 citations

A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase

1996 • 208 citations

Mutagenic potency of exocyclic DNA adducts: marked differences between Escherichia coli and simian kidney cells.

1994 • 202 citations

Spontaneous mutation in the Escherichia coli lacI gene.

1991 • 200 citations

In vitro correction of G o T mispairs to G o C pairs in nuclear extracts from human cells

1989 • 191 citations

Mutation spectrum of copper-induced DNA damage.

1991 • 190 citations

Reverse chemical mutagenesis: identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA.

1994 • 189 citations

Isolation and Characterization of Endonuclease VIII from Escherichia coli

1994 • 167 citations

Mutational properties of the primary aflatoxin B1-DNA adduct.

1996 • 164 citations

Major oxidative products of cytosine, 5-hydroxycytosine and 5-hydroxyuracil, exhibit sequence context-dependent mispairingin vitro

1994 • 159 citations

Efficient removal of uracil from G.U mispairs by themismatch-specific thymine DNA glycosylase from HeLa cells.

1994 • 146 citations

Mutagenesis by hydrogen peroxide treatment of mammalian cells: a molecular analysis

1990 • 120 citations

Formation of cytosine glycol and 5,6-dihydroxycytosine in deoxyribonucleic acid on treatment with osmium tetroxide

1986 • 113 citations

Molecular analysis of O6-substituted guanine-induced mutagenesis of ras oncogenes.

1989 • 103 citations

SOS-dependent replication past a single trans-syn T-T cyclobutane dimer gives a different mutation spectrum and increased error rate compared with replication past this lesion in uninduced cells

1990 • 98 citations

5-Hydroxypyrimidine deoxynucleoside triphosphates are more efficiently incorporated into DNA by exonuclease-free Klenow fragment than 8-oxopurine deoxynucleoside triphosphates

1994 • 73 citations

Excision of Oxidative Cytosine Modifications from γ-Irradiated DNA byEscherichia coliEndonuclease III and Human Whole-Cell Extracts

1996 • 43 citations

Specificity of mutagenesis by 4-aminobiphenyl. A possible role for N-(deoxyadenosin-8-yl)-4-aminobiphenyl as a premutational lesion.

1988 • 38 citations

Kinetics of Oxidized Cytosine Repair by Endonuclease III of Escherichia coli

1997 • 32 citations

Synthesis of Oligonucleotides Containing Two Putatively Mutagenic DNA Lesions: 5-Hydroxy-2‘-deoxyuridine and 5-Hydroxy-2‘-deoxycytidine

1997 • 20 citations

A Viral Genome Containing an Unstable Aflatoxin B1-N7-Guanine DNA Adduct Situated at a Unique Site

1996 • 15 citations

Studies on the effect of triphosphates of 5-aminouridine and 5-hydroxydeoxyuridine on ribonucleic acid and deoxyribonucleic acid polymerases

1970 • 10 citations