Mutagenicity in Escherichia coli of the major DNA adduct derived from the endogenous mutagen malondialdehyde

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Instability and decay of the primary structure of DNA

1993 • 5,370 citations

Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury

1990 • 2,639 citations

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

1994 • 2,553 citations

Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.

1995 • 837 citations

Endogenous mutagens and the causes of aging and cancer

1991 • 725 citations

FIDELITY MECHANISMS IN DNA REPLICATION

1991 • 709 citations

Detection of Endogenous Malondialdehyde-Deoxyguanosine Adducts in Human Liver

1994 • 368 citations

Mutagenicity of Malonaldehyde, a Decomposition Product of Peroxidized Polyunsaturated Fatty Acids

1976 • 356 citations

Endogenous DNA adducts: Potential and paradox

1993 • 284 citations

Increased formation of oxidative DNA damage, 8-hydroxydeoxyguanosine, in human livers with chronic hepatitis.

1994 • 277 citations

Unequivocal demonstration that malondialdehyde is a mutagen

1983 • 269 citations

Increase of a type of oxidative DNA damage, 8-hydroxyguanine, and its repair activity in human leukocytes by cigarette smoking.

1996 • 253 citations

1,N⁶-Ethenodeoxyadenosine and 3,N⁴-ethenodeoxycytidine in liver DNA from humans and untreated rodents detected by immunoaffinity/³²P-postlabelling

1995 • 212 citations

Mutagenic potency of exocyclic DNA adducts: marked differences between Escherichia coli and simian kidney cells.

1994 • 202 citations

Activity of the purified mutagenesis proteins UmuC, UmuD', and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase III.

1992 • 199 citations

1,N⁶-Ethenodeoxyadenosine, a DNA Adduct Highly Mutagenic in Mammalian Cells

1996 • 178 citations

Mutagenic and genotoxic effects of three vinyl chloride-induced DNA lesions: 1,N6-ethenoadenine, 3,N4-ethenocytosine, and 4-amino-5-(imidazol-2-yl)imidazole

1993 • 174 citations

Determination of DNA adducts of malonaldehyde in humans: effects of dietary fatty acid composition

1996 • 132 citations

Mutagenicity and cytotoxicity of malonaldehyde in mammalian cells

1979 • 129 citations

Analysis of the Malondialdehyde−2‘- Deoxyguanosine Adduct Pyrimidopurinone in Human Leukocyte DNA by Gas Chromatography/Electron Capture/Negative Chemical Ionization/Mass Spectrometry

1997 • 110 citations

The Role of Cyclic Nucleic Acid Adducts in Carcinogenesis and Mutagenesis

1987 • 106 citations

Repair of Propanodeoxyguanosine by Nucleotide Excision Repair in Vivo and in Vitro

1997 • 91 citations

Induction of mutations by replication of malondialdehyde modified M13 DNA in Escherichia coil: determination of the extent of DNA modification, genetic requirements for mutagenesis, and types of mutations induced

1995 • 91 citations

7-Methylguanine levels in DNA of smokers' and non-smokers' total white blood cells, granulocytes and lymphocytes

1992 • 78 citations

³²P-Postlabelling determination of DNA adducts of malonadlehyde in humans: total white blood cells and breast tissue

1995 • 67 citations

Dose-response relationships for carcinogens

1995 • 66 citations

Mechanisms of mutagenesis by exocyclic DNA adducts. Transfection of M13 viral DNA bearing a site-specific adduct shows that ethenocytosine is a highly efficient RecA-independent mutagenic noninstructional lesion

1991 • 63 citations

Characterization of endogenous DNA adducts by liquid chromatography/electrospray ionization tandem mass spectrometry

1995 • 60 citations

Quantitative multiplex sequence analysis of mutational hot spots. Frequency and specificity of mutations induced by a site-specific ethenocytosine in M13 viral DNA

1993 • 55 citations

Site-specific frameshift mutagenesis by a propanodeoxyguanosine adduct positioned in the (CpG)4 hot-spot of Salmonella typhimurium hisD3052 carried on an M13 vector.

1992 • 55 citations

Site-specific mutagenesis by a propanodeoxyguanosine adduct carried on an M13 genome.

1994 • 53 citations

Temperature-Dependent Formation of a Conjugate between Tris(hydroxymethyl)aminomethane Buffer and the Malondialdehyde−DNA Adduct Pyrimidopurinone

1997 • 33 citations

Sequence-dependent Induction of Base Pair Substitutions and Frameshifts by Propanodeoxyguanosine during in Vitro DNA Replication

1996 • 31 citations

Synthesis of an Oligodeoxyribonucleotide Containing the Alkaline Labile Malondialdehyde-Deoxyguanosine Adduct Pyrimido[1,2-a]purin-10(3H)-one

1995 • 20 citations

Relative Contribution of Cytosine Deamination and Error-Prone Replication to the Induction of Propanodeoxyguanosine → Deoxyadenosine Mutations in Escherichia coli

1996 • 14 citations

Construction of a vector for site-specific frameshift mutagenesis containing the mutable hotspot of Salmonella typhimurium TA98 on an M13 bacteriophage

1993 • 9 citations