DNA base modifications in chromatin of human cancerous tissues

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

Production of large amounts of hydrogen peroxide by human tumor cells.

1991 • 2,465 citations

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

1992 • 1,830 citations

The chemical basis of radiation biology

1987 • 1,788 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systems

1991 • 1,555 citations

Biological effects of the superoxide radical

1986 • 1,446 citations

Purine bases, nucleosides, and nucleotides: aqueous solution redox chemistry and transformation reactions of their radical cations and e- and OH adducts

1989 • 1,215 citations

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

1990 • 1,100 citations

Free radicals, antioxidant enzymes, and carcinogenesis

1990 • 1,090 citations

Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair

1986 • 933 citations

Role of oxygen free radicals in carcinogenesis and brain ischemia

1990 • 885 citations

Ascorbic acid protects against endogenous oxidative DNA damage in human sperm.

1991 • 784 citations

Endogenous Oxidative DNA Damage, Aging, and Cancer

1989 • 711 citations

Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome

1990 • 687 citations

Oxidative damage to DNA: relation to species metabolic rate and life span.

1988 • 587 citations

Chemical determination of free radical-induced damage to DNA

1991 • 523 citations

Thymine glycol and thymidine glycol in human and rat urine: a possible assay for oxidative DNA damage.

1984 • 365 citations

Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: The role of dna base damage

1990 • 364 citations

Site-specific mutagenesis using a gapped duplex vector: A study of translesion synthesis past 8-oxodeoxyguanosine in E. coli

1991 • 309 citations

Spontaneous cancer and its possible relationship to oxygen metabolism.

1980 • 298 citations

Increasing metastatic potential is associated with increasing genetic instability of clones isolated from murine neoplasms.

1981 • 291 citations

Major alterations in the nucleotide structure of DNA in cancer of the female breast.

1991 • 271 citations

Modification of DNA bases in mammalian chromatin by radiation-generated free radicals

1990 • 255 citations

Cigarette smoke induces DNA single-strand breaks in human cells

1985 • 248 citations

Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies.

1989 • 204 citations

Application of capillary gas chromatography-mass spectrometry to chemical characterization of radiation-induced base damage of DNA: Implications for assessing DNA repair processes

1985 • 160 citations

Cigarette smoke-induced DNA damage in cultured human lung cells: Role of hydroxyl radicals and endonuclease activation

1992 • 158 citations

The formation, identification, and significance of DNA-protein cross-links in mammalian cells.

1987 • 141 citations

Formation and repair of γ-ray induced thymine damage in Micrococcus radiodurans

1972 • 140 citations

Thymine lesions produced by ionizing radiation in double-stranded DNA

1985 • 138 citations

Nickel(II)- and cobalt(II)-dependent damage by hydrogen peroxide to the DNA bases in isolated human chromatin.

1991 • 126 citations

Chemical nature of in vivo DNA base damage in hydrogen peroxide-treated mammalian cells

1991 • 122 citations

Monoclonal antibody to DNA containing thymine glycol

1983 • 119 citations

Lymphocyte subsets in tumour of patients with undifferentiated nasopharyngeal carcinoma: presence of lymphocytes with the phenotype of activated T cells

1987 • 119 citations

A mutant protein kinase C that can transform fibroblasts

1989 • 119 citations

Ionizing radiation and tritium transmutation both cause formation of 5-hydroxymethyl-2'-deoxyuridine in cellular DNA.

1984 • 116 citations

Formation of cytosine glycol and 5,6-dihydroxycytosine in deoxyribonucleic acid on treatment with osmium tetroxide

1986 • 113 citations

Quantitative determination of the 5-(hydroxymethyl)uracil moiety in the DNA of .gamma.-irradiated cells

1985 • 108 citations

Oxidative damage in DNA

1988 • 108 citations

DNA Base Damage in Chromatin of γ-Irradiated Cultured Human Cells

1992 • 105 citations

A novel DNA lesion in neoplastic livers of feral fish: 2,6-diamino-4-hydroxy-5-formamidopyrimidine

1990 • 84 citations

Analysis of methylated and oxidized purines in urine by capillary gas chromatography-mass spectrometry

1989 • 83 citations

Structure andin vitroreplication of DNA templates containing 7,8-dihydro-8-oxoadenine

1991 • 82 citations

Genetic effects of 5-hydroxymethyl-2′-deoxyuridine, a product of ionizing radiation

1987 • 68 citations

4,6-diamino-5-formamidopyrimidine, 8-hydroxyguanine and 8-hydroxyadenine in DNA from neoplastic liver of english sole exposed to carcinogens

1990 • 64 citations

Selective excision of gamma ray damaged thymine from the DNA of cultured mammalian cells

1975 • 61 citations

[46] Gas chromatography—mass spectrometry of free radical-induced products of pyrimidines and purines in DNA

1990 • 52 citations

The etiology of cancer: hydroxyl radical-induced DNA lesions in histologically normal livers offish from a population with liver tumors

1991 • 47 citations

Radiation-induced Thymine Base Damage and Its Excision Repair in Active and Inactive Chromatin of HeLa Cells

1985 • 28 citations

Production and Repair of DNA Damage in Mammalian Cells

1990 • 19 citations