Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

Membrane lipid oxidation

1990 • 389 citations

Detection of Endogenous Malondialdehyde-Deoxyguanosine Adducts in Human Liver

1994 • 368 citations

Formation of cyclic 1,N2-propanodeoxyguanosine adducts in DNA upon reaction with acrolein or crotonaldehyde.

1984 • 295 citations

The Hepatocellular Metabolism of 4-Hydroxynonenal by Alcohol Dehydrogenase, Aldehyde Dehydrogenase, and Glutathione S-Transferase

1995 • 242 citations

Metabolism of the lipid peroxidation product 4-hydroxynonenal by isolated hepatocytes and by liver cytosolic fractions

1985 • 235 citations

Formation of 1,N6-Ethenoadenine and 3,N4-Ethenocytosine by Lipid Peroxidation Products and Nucleic Acid Bases

1995 • 220 citations

Detection of exocyclic 1,N2-propanodeoxyguanosine adducts as common DNA lesions in rodents and humans.

1994 • 217 citations

1,N⁶-Ethenodeoxyadenosine and 3,N⁴-ethenodeoxycytidine in liver DNA from humans and untreated rodents detected by immunoaffinity/³²P-postlabelling

1995 • 212 citations

Mutagenic potency of exocyclic DNA adducts: marked differences between Escherichia coli and simian kidney cells.

1994 • 202 citations

Mutagenic and genotoxic effects of three vinyl chloride-induced DNA lesions: 1,N6-ethenoadenine, 3,N4-ethenocytosine, and 4-amino-5-(imidazol-2-yl)imidazole

1993 • 174 citations

Genotoxic properties of 4-hydroxyalkenals and analogous aldehydes

1993 • 166 citations

Formation of cyclic adducts of deoxyguanosine with the aldehydes trans-4-hydroxy-2-hexenal and trans-4-hydroxy-2-nonenal in vitro.

1986 • 159 citations

All four known cyclic adducts formed in DNA by the vinyl chloride metabolite chloroacetaldehyde are released by a human DNA glycosylase.

1994 • 148 citations

Mercapturic Acid Conjugates as Urinary End Metabolites of the Lipid Peroxidation Product 4-Hydroxy-2-nonenal in the Rat

1995 • 139 citations

1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal.

1988 • 129 citations

The vinyl chloride DNA derivative N2,3-ethenoguanine produces G----A transitions in Escherichia coli.

1991 • 118 citations

Etheno adducts formed in DNA of vinyl chloride-exposed rats are highly persistent in liver

1992 • 111 citations

Interactions of vinyl chloride with rat-liver DNA in vivo

1978 • 110 citations

The Role of Cyclic Nucleic Acid Adducts in Carcinogenesis and Mutagenesis

1987 • 106 citations

Vinyl chloride-induced DNA adducts II: Formating and persistence of 7-(2'oxoethyl)guanine and N² ,3 ethenoguanine in rat tissue DNA

1990 • 106 citations

Both purified human 1,N6-ethenoadenine-binding protein and purified human 3-methyladenine-DNA glycosylase act on 1,N6-ethenoadenine and 3-methyladenine.

1992 • 102 citations

Stereoselective formation of in vitro nucleic acid adducts by 2,3-epoxy-4-hydroxynonanal.

1991 • 97 citations

Copper-dependent formation of miscoding etheno-DNA adducts in the liver of Long Evans cinnamon (LEC) rats developing hereditary hepatitis and hepatocellular carcinoma.

1996 • 93 citations

Carcinogenicity of chloroethylene oxide, an ultimate reactive metabolite of vinyl chloride, and bis(chloromethyl)ether after subcutaneous administration and in initiation-promotion experiments in mice.

1980 • 86 citations

1,N⁶-etheno-2′ -deoxyadenosine and 3,N⁴-etheno-2′-deoxycytidine detected by monoclonal antibodies in lung and liver DNA of rats exposed to vinyl chloride

1989 • 82 citations

Alkylation of RNA by vinyl chloride metabolites in vitro and in vivo: Formation of 1-N6-etheno-adenosine

1977 • 78 citations

Formation of cyclic 1,N2--adducts by reaction of deoxyguanosine with alpha-acetoxy-N-nitrosopyrrolidine, 4-(carbethoxynitrosamino)butanal, or crotonaldehyde.

1983 • 75 citations

Release of N2,3-ethenoguanine from chloroacetaldehyde-treated DNA by Escherichia coli 3-methyladenine DNA glycosylase II.

1992 • 73 citations

The vinyl chloride-derived nucleoside, N²,3-ethenoguanosine, is a highly efficient mutagen in transcription

1987 • 68 citations

Structural characterization of adducts formed in the reaction of 2,3-epoxy-4-hydroxynonanal with deoxyguanosine

1989 • 67 citations

Dose-response relationships for carcinogens

1995 • 66 citations

2,3-Epoxy-4-hydroxynonanal as a potential tumor-initiating agent of lipid peroxidation

1993 • 64 citations

Formation of Etheno Adducts in Reactions of Enals via Autoxidation

1994 • 63 citations

Mechanisms of mutagenesis by exocyclic DNA adducts. Transfection of M13 viral DNA bearing a site-specific adduct shows that ethenocytosine is a highly efficient RecA-independent mutagenic noninstructional lesion

1991 • 63 citations

Labeled 1,N⁶-ethenoadenosine and 3,N⁴-ethenocytidine in hepatic RNA of mice given [ethyl-1,2-³H or ethyl-1-¹⁴C] ethyl carbamate (urethan)

1982 • 61 citations

Detection of cyclic 1, N²-propanodeoxyguanosine adducts in DNA of rats treated with N-nitrosopyrrolidine and mice treated with crotonaldehyde

1989 • 53 citations

Formation of 1,N2- and N2,3-ethenoguanine from 2-halooxiranes: Isotopic labeling studies and isolation of a hemiaminal derivative of N2-(2-oxoethyl)guanine

1993 • 48 citations

Application of an immunoassay for cyclic acrolein deoxyguanosine adducts to assess their formation in DNA of Salmonella typhimurium under conditions of mutation induction by acrolein

1989 • 46 citations

Detection of 1,N6-propanodeoxyadenosine in acrolein-modified polydeoxyadenylic acid and DNA by 32P postlabeling.

1990 • 45 citations

Identification and characterization of deoxyguanosine-crotonaldehyde adducts. Formation of 7,8 cyclic adducts and 1,N2,7,8-bis-cyclic adducts

1992 • 39 citations

Determination of Aldehydic Lipid Peroxidation Products With Dabsylhydrazine by High-Performance Liquid Chromatography

1995 • 37 citations

Mechanisms of Formation of Adducts from Reactions of Glycidaldehyde with 2‘-Deoxyguanosine and/or Guanosine

1996 • 37 citations

Human cells contain protein specifically binding to a single 1,N6-ethenoadenine in a DNA fragment.

1991 • 36 citations

The LEC rat : a new model for hepatitis and liver cancer

1991 • 35 citations

Ring-extended products from the reaction of epoxy carbonyl compounds and nucleic acid bases

1985 • 30 citations

Reaction of acrolein with cytosine and adenine derivatives

1988 • 29 citations

A ³²P-postlabeling method for simultaneous detection and quantification of exocyclic etheno and propano adducts in DNA

1994 • 27 citations

Elevation of the level of lipid peroxidation associated with hepatic injury in LEC mutant rat.

1992 • 26 citations

Partial purification of a human DNA glycosylase acting on the cyclic carcinogen adduct 1,N6-ethenodeoxyadenosine.

1992 • 25 citations

Reactions of nucleosides with glyoxal and acrolein.

1986 • 18 citations

The Lec Rat: A New Model for Hepatitis and Liver Cancer

1992 • 3 citations