Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferase

Molecular Cloning: A Laboratory Manual

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Experiments in molecular genetics

1972 • 28,260 citations

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1943 • 3,852 citations

The distribution of the numbers of mutants in bacterial populations

1949 • 1,471 citations

The origin of mutants

1988 • 1,029 citations

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

1969 • 949 citations

A collection of strains containing genetically linked alternating antibiotic resistance elements for genetic mapping of Escherichia coli

1989 • 762 citations

A new pathway for DNA repair in Escherichia coli

1977 • 705 citations

REGULATION AND EXPRESSION OF THE ADAPTIVE RESPONSE TO ALKYLATING AGENTS

1988 • 645 citations

Interaction of lipid peroxidation products with DNA. A review

1988 • 455 citations

A set of lacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutions.

1989 • 451 citations

Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue.

1980 • 438 citations

Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction.

1982 • 398 citations

Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine.

1990 • 292 citations

Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents

1982 • 287 citations

Adaptation to alkylation resistance involves the induction of a DNA glycosylase

1982 • 283 citations

Inducible repair of O-alkylated DNA pyrimidines in Escherichia coli.

1984 • 223 citations

The intracellular signal for induction of resistance to alkylating agents in E. coli

1986 • 222 citations

Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis.

1985 • 221 citations

Repair of O6-methylguanine in adapted Escherichia coli.

1978 • 180 citations

Characterisation and nucleotide sequence ofogt, the O⁶-alkyiguanine-DNA-alkyltransferase gene ofE.coli

1987 • 163 citations

Induction of resistance to alkylating agents in E. coli: the ada+ gene product serves both as a regulatory protein and as an enzyme for repair of mutagenic damage.

1984 • 162 citations

Nonenzymatic methylation of DNA by S-adenosylmethionine in vitro

1982 • 161 citations

Isolation and characterization of Escherichia coli K-12 mutants unable to induce the adaptive response to simple alkylating agents

1979 • 160 citations

Mutagenic potential of O4-methylthymine in vivo determined by an enzymatic approach to site-specific mutagenesis.

1986 • 143 citations

A unicorn in the garden

1988 • 140 citations

Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein ofE. coli

1985 • 139 citations

A system in mouse liver for the repair of O⁶-methylguanine lesions in methylated DNA

1981 • 137 citations

Base-pairing properties of O6-methylguanine in template DNA during in vitro DNA replication.

1984 • 133 citations

cDNA cloning and chromosomal assignment of the human O6-methylguanine-DNA methyltransferase. cDNA expression in Escherichia coli and gene expression in human cells.

1990 • 113 citations

Molecular cloning of a gene which regulates the adaptive response to alkylating agents in Escherichia coli

1983 • 110 citations

Functional domains and methyl acceptor sites of the Escherichia coli ada protein.

1988 • 107 citations

Pathways of mutagenesis and repair in Escherichia coli exposed to low levels of simple alkylating agents

1978 • 95 citations

Isolation of mutants of Escherichia coli with increased resistance to alkylating agents: Mutants deficient in thiols and mutants constitutive for the adaptive response

1980 • 95 citations

Construction of an Escherichia coli K-12 ada deletion by gene replacement in a recD strain reveals a second methyltransferase that repairs alkylated DNA

1988 • 89 citations

Induction and autoregulation of ada, a positively acting element regulating the response of Escherichia coli K-12 to methylating agents

1985 • 87 citations

Induction of specific Escherichia coli genes by sublethal treatments with alkylating agents.

1984 • 82 citations

Purification of theE.coliogt gene product to homogeneity and its rate of action onO⁶-methylguanine,O⁶-ethyiguanine andO⁴-methylthymine in dodecadeoxyribnucleotides

1989 • 81 citations

A second DNA methyltransferase repair enzyme in Escherichia coli.

1988 • 77 citations

ESCHERICHIA COLI GENE INDUCTION BY ALKYLATION TREATMENT

1986 • 74 citations

O6-methylguanine-DNA methyltransferase in wild-type and ada mutants of Escherichia coli

1982 • 70 citations

Identification and preliminary characterization of an O6-methylguanine DNA repair methyltransferase in the yeast Saccharomyces cerevisiae.

1990 • 68 citations

Efficiency of the adaptive response of Escherichia coli to alkylating agents

1980 • 61 citations

Characterization of the major DNA repair methyltransferase activity in unadapted Escherichia coli and identification of a similar activity in Salmonella typhimurium

1989 • 60 citations

Functional sites of the Ada regulatory protein of Escherichia coli

1988 • 59 citations

Phasmid vectors for identification of genes by complementation of Escherichia coli mutants

1985 • 47 citations

Expression of theogtgene in wild-type andadamutants ofE.coli

1989 • 44 citations

Mutation spectrum inEscherichia coliDNA mismatch repair deficient (mutH) strain

1987 • 44 citations

O⁶-Methylguanine DNA methyltransferase activity in liver from various fish species

1987 • 40 citations

Multiple species of Bacillus subtilis DNA alkyltransferase involved in the adaptive response to simple alkylating agents

1987 • 30 citations

Repair of alkylated DNA: Drosophila have DNA methyltransferases but not DNA glycosylases

1983 • 27 citations

N-nitrosamine formation by microorganisms isolated from human gastric juice and urine: biochemical studies on bacteria-catalysed nitrosation.

1987 • 14 citations

Adaptive response induction by bacterial catalysis of nitrosation

1990 • 13 citations

Mapping of OGT in theE. colichromosome

1989 • 9 citations

A constitutive O6-methylguanine-DNA methyltransferase of Rhizobium meliloti

1990 • 7 citations

O⁶-methylguanine in the SV40 origin of replication inhibits binding but increases unwinding by viral large T antigen

1990 • 6 citations