The gene PC3^TIS21/BTG2, prototype member of the PC3/BTG/TOB family: Regulator in control of cell growth, differentiation, and DNA repair?

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Neurotrophin signal transduction in the nervous system

2000 • 1,910 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

Cyclin/PCNA is the auxiliary protein of DNA polymerase-δ

1987 • 1,766 citations

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

1993 • 1,605 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Increasing complexity of Ras signaling

1998 • 1,069 citations

Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB

1990 • 1,061 citations

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

1993 • 1,057 citations

Hox genes and the evolution of vertebrate axial morphology

1995 • 825 citations

Proliferating cell nuclear antigen is required for DNA excision repair

1992 • 809 citations

High-frequency developmental abnormalities in p53-deficient mice

1995 • 464 citations

EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor

1994 • 455 citations

The Mammalian Immediate-early TIS21 Protein and the Leukemia-associated BTG1 Protein Interact with a Protein-arginine -Methyltransferase

1996 • 435 citations

DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis

1999 • 423 citations

Identification of BTG2, an antiproliferative p53–dependent component of the DNA damage cellular response pathway

1996 • 416 citations

Induction of Neuronal Differentiation in PC12 Cells by B-Cell Stimulatory Factor 2/Interleukin 6

1988 • 402 citations

Control of pRB phosphorylation

1998 • 389 citations

Cyclin D1 is an essential mediator of apoptotic neuronal cell death.

1996 • 383 citations

Inhibition of Ras-Induced Proliferation and Cellular Transformation by p16 ^INK4

1995 • 382 citations

Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells

1987 • 353 citations

Cyclin D1 Is Required for Transformation by Activated Neu and Is Induced through an E2F-Dependent Signaling Pathway

2000 • 346 citations

The potential tumor suppressor p73 differentially regulates cellular p53 target genes.

1998 • 324 citations

BTG1, a member of a new family of antiproliferative genes.

1992 • 298 citations

Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts.

1994 • 296 citations

Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6.

1988 • 295 citations

[18] PC12 pheochromocytoma cells: culture, nerve growth factor treatment, and experimental exploitation

1987 • 243 citations

Arrest of G₁-S Progression by the p53-Inducible Gene PC3 Is Rb Dependent and Relies on the Inhibition of Cyclin D1 Transcription

2000 • 226 citations

Multiple sequence elements in the c-fos promoter mediate induction by cAMP.

1989 • 225 citations

Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons.

1992 • 221 citations

Gene expression screening in Xenopus identifies molecular pathways, predicts gene function and provides a global view of embryonic patterning

1998 • 209 citations

The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively

1998 • 207 citations

Expression of the antiproliferative gene TIS21 at the onset of neurogenesis identifies single neuroepithelial cells that switch from proliferative to neuron-generating division

1999 • 203 citations

Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity.

1996 • 190 citations

Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization.

1991 • 185 citations

A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor

1997 • 179 citations

NGF regulates the PC12 cell cycle machinery through specific inhibition of the Cdk kinases and induction of cyclin D1

1995 • 177 citations

Cell cycle-specific action of nerve growth factor in PC12 cells: differentiation without proliferation.

1989 • 176 citations

Initiation, establishment and maintenance of Hox gene expression patterns in the mouse.

1999 • 176 citations

Suppression of nerve growth factor-directed neurite outgrowth in PC12 cells by sphingosine, an inhibitor of protein kinase C.

1988 • 172 citations

Tumor suppressor genes

2000 • 170 citations

Structure and expression of TIS21, a primary response gene induced by growth factors and tumor promoters

1991 • 166 citations

p16^INK4A Participates in a G₁ Arrest Checkpoint in Response to DNA Damage

1998 • 163 citations

Neurotrophin receptors: mediators of life and death

1998 • 161 citations

Inhibition of Cyclin D1 Kinase Activity Is Associated with E2F-Mediated Inhibition of Cyclin D1 Promoter Activity through E2F and Sp1

1998 • 160 citations

Protein methylation: a signal event in post-translational modification

1998 • 159 citations

p53, through p21 (WAF1/CIP1), induces cyclin D1 synthesis.

1995 • 155 citations

Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases

1999 • 139 citations

A timetable of events during programmed cell death induced by trophic factor withdrawal from neuronal PC12 cells

1995 • 138 citations

The Leukemia-associated Protein Btg1 and the p53-regulated Protein Btg2 Interact with the Homeoprotein Hoxb9 and Enhance Its Transcriptional Activation

2000 • 135 citations

Suppression of a new allele of the yeast RAD52 gene by overexpression of RAD51, mutations in srs2 and ccr4, or mating-type heterozygosity.

1995 • 133 citations

[21] Progressive alignment of amino acid sequences and construction of phylogenetic trees from them

1996 • 127 citations

Interaction of BTG1 and p53-regulatedBTG2 Gene Products with mCaf1, the Murine Homolog of a Component of the Yeast CCR4 Transcriptional Regulatory Complex

1998 • 125 citations

Regulation and function of the p53-related proteins: same family, different rules

2000 • 123 citations

Immediate early gene induction after neonatal hypoxia-ischemia

1993 • 121 citations

Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle

1997 • 121 citations

Loss of heterozygosity on chromosome 1q in human breast cancer.

1989 • 119 citations

Targeted Mutations inHoxa-9andHoxb-9Reveal Synergistic Interactions

1997 • 118 citations

Differential regulation of cellular target genes by p53 devoid of the PXXP motifs with impaired apoptotic activity

1999 • 115 citations

ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system

1998 • 107 citations

DBF2, a cell cycle-regulated protein kinase, is physically and functionally associated with the CCR4 transcriptional regulatory complex

1997 • 106 citations

Patterning of the mesoderm in Xenopus: dose-dependent and synergistic effects of Brachyury and Pintallavis

1995 • 105 citations

6 Hox Genes and the Global Patterning of the Somitic Mesoderm

1999 • 102 citations

BTG gene expression in the p53-dependent and -independent cellular response to DNA damage

2000 • 88 citations

A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus in a t(8; 12)(q24;q22) translocation in a case of B‐cell chronic lymphocytic leukemia

1991 • 87 citations

Differential Regulation of Immediate Early Gene Expression in Preadipocyte Cells through Multiple Signaling Pathways

1999 • 86 citations

Overexpression of the nerve growth factor-inducible PC3 immediate early gene is associated with growth inhibition.

1996 • 85 citations

Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1

1998 • 84 citations

Mismatch repair in correction of replication errors and processing of DNA damage

2001 • 82 citations

TRA-1A regulates transcription of fog-3, which controls germ cell fate in C. elegans

2000 • 80 citations

Cell Cycle and Cancer: Critical Events at the G1 Restriction Point

1996 • 78 citations

A Novel Member of the Tob Family of Proteins Controls Sexual Fate in Caenorhabditis elegans Germ Cells

2000 • 77 citations

Induction of growth inhibition of 293 cells by downregulation of the cyclin E and cyclin-dependent kinase 4 proteins due to overexpression of TIS21

1998 • 72 citations

A screen for targets of the Xenopus T-box gene Xbra

2000 • 66 citations

Cloning of PC3B, a Novel Member of the PC3/BTG/TOB Family of Growth Inhibitory Genes, Highly Expressed in the Olfactory Epithelium

2000 • 66 citations

Involvement of JunD in transcriptional activation of the orphan receptor gene nur77 by nerve growth factor and membrane depolarization in PC12 cells.

1994 • 55 citations

Tumor Promoter-Inducible Genes Are Differentially Expressed in the Developing Mouse

1988 • 53 citations

BTG1: A Triiodothyronine Target Involved in the Myogenic Influence of the Hormone

1999 • 53 citations

Effect of nerve growth factor on the expression of cell cycle regulatory proteins in PC12 cells: dissection of the neurotrophic response from the anti-mitogenic response.

1996 • 53 citations

Antiproliferative gene BTG1 is highly expressed in apoptotic cells in macrophage-rich areas of advanced lesions in Watanabe heritable hyperlipidemic rabbit and human.

1998 • 50 citations

Developmental expression of PC3 gene is correlated with neuronal cell birthday

1994 • 49 citations

Stimulation of Avian Myoblast Differentiation by Triiodothyronine: Possible Involvement of the cAMP Pathway

1995 • 46 citations

Rapid dephosphorylation of p107 following UV irradiation

1999 • 46 citations

Tumor promoter-inducible genes are differentially expressed in the developing mouse.

1988 • 42 citations

Genes Induced in Programmed Cell Death of Neuronal PC12 Cells and Developing Sympathetic Neuronsin Vivo

1997 • 39 citations

Synthesis, degradation, and subcellular localization of proteins encoded by the primary response genes TIS7/PC4 and TIS21/PC3

1994 • 38 citations

PC3 overexpression affects the pattern of cell division of rat cortical precursors

2000 • 37 citations

Stage-specific expression of B cell translocation gene 1 in rat testis.

1995 • 27 citations

Cloning and characterization of the mouse tob gene

1997 • 26 citations

Identification of Genes Associated with Stromal Hyperplasia and Glandular Atrophy of the Prostate by mRNA Differential Display

1998 • 23 citations

Sequence and developmental expression ofAmphiTob, an amphioxus homolog of vertebrateTob in thePC3/BTG1/Tob family of tumor suppressor genes

1997 • 22 citations

Overexpression of the PC3/TIS21/BTG2 mRNA Is Part of the Stress Response Induced by Acute Pancreatitis in Rats

1998 • 21 citations

Induction of tetradecanoyl phorbol acetate-inducible sequence (TIS) genes by electroconvulsive shock in rat brain

1996 • 17 citations

Enhancement of B‐cell translocation gene‐1 expression by prostaglandin E₂ in macrophages and the relationship to proliferation

1997 • 16 citations

Cloning and characterization of the mouse tob2 gene

2000 • 15 citations

Enzymatic methylation of recombinant TIS21 protein‐arginine residues

1998 • 12 citations

Modulation of signal transduction in macrophages by dietary fatty acids.

1995 • 9 citations

Stage-specific expression of B cell translocation gene 1 in rat testis

1995 • 8 citations

Inhibition of Human Pancreatic Cancer Growth by the Adenovirus-Mediated Introduction of a Novel Growth Suppressing Gene, tob, In Vitro

1998 • 7 citations

[Mechanisms of BTG2 activity, a transcriptional target of p53: evidences and hypothesis].

1999 • 7 citations