Involvement of JunD in transcriptional activation of the orphan receptor gene nur77 by nerve growth factor and membrane depolarization in PC12 cells.

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

The regulation and function of c-fos and other immediate early genes in the nervous system

1990 • 2,392 citations

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

1990 • 1,507 citations

CREB: a Ca ²⁺ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases

1991 • 1,476 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

1991 • 1,300 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways

1993 • 1,165 citations

PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERS

1991 • 1,078 citations

Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB

1990 • 1,061 citations

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

1991 • 1,049 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

DNA binding activities of three murine Jun proteins: Stimulation by Fos

1988 • 850 citations

Stimulation of Neuronal Acetylcholine Receptors Induces Rapid Gene Transcription

1986 • 761 citations

Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB

1994 • 732 citations

PC12 Pheochromocytoma Cultures in Neurobiological Research

1982 • 728 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element

1992 • 688 citations

Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene

1988 • 661 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.

1990 • 630 citations

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1994 • 571 citations

Identification of the DNA Binding Site for NGFI-B by Genetic Selection in Yeast

1991 • 566 citations

DNA binding site of the growth factor-inducible protein Zif268.

1989 • 563 citations

cAMP response element-binding protein is activated by Ca2+/calmodulin- as well as cAMP-dependent protein kinase.

1991 • 552 citations

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77

1994 • 551 citations

c-JUN, JUN B, and JUN D differ in their binding affinities to AP-1 and CRE consensus sequences: effect of FOS proteins.

1991 • 543 citations

A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily.

1988 • 532 citations

Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction.

1989 • 502 citations

jun-D: a third member of the jun gene family.

1989 • 469 citations

Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF

1991 • 447 citations

Upstream regions of the human cardiac actin gene that modulate its transcription in muscle cells: presence of an evolutionarily conserved repeated motif.

1986 • 432 citations

Calcium and growth factor pathways of c-fos transcriptional activation require distinct upstream regulatory sequences.

1988 • 404 citations

Identification and purification of a polypeptide that binds to the c-fos serum response element.

1987 • 398 citations

Nerve growth factor-induced increase in electrical excitability and acetylcholine sensitivity of a rat pheochromocytoma cell line

1977 • 395 citations

Expression of different Jun and Fos proteins during the G0-to-G1 transition in mouse fibroblasts: in vitro and in vivo associations.

1991 • 309 citations

Regulation of the differentiation of PC12 pheochromocytoma cells.

1989 • 296 citations

The SRE: a growth factor responsive transcriptional regulator.

1990 • 287 citations

Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions.

1983 • 273 citations

Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene.

1991 • 272 citations

The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase.

1993 • 243 citations

Multiple sequence elements in the c-fos promoter mediate induction by cAMP.

1989 • 225 citations

Existence of different Fos/Jun complexes during the G0-to-G1 transition and during exponential growth in mouse fibroblasts: differential role of Fos proteins.

1992 • 198 citations

Transcriptional cross-talk: nuclear factors CREM and CREB bind to AP-1 sites and inhibit activation by Jun.

1992 • 197 citations

Asymmetrical recognition of the palindromic AP1 binding site (TRE) by Fos protein complexes.

1989 • 191 citations

Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor.

1989 • 188 citations

Dissecting the Mode of Action of a Neuronal Growth Factor

1991 • 179 citations

Molecular Aspects of Cellular Regulation

1986 • 168 citations

The NGFI-B gene, a transcriptionally inducible member of the steroid receptor gene superfamily: genomic structure and expression in rat brain after seizure induction.

1989 • 167 citations

Induction of immediate early genes by Ca2+ influx requires cAMP-dependent protein kinase in PC12 cells.

1991 • 155 citations

Endocrine and neurogenic regulation of the orphan nuclear receptors Nur77 and Nurr-1 in the adrenal glands.

1994 • 154 citations

cAMP-dependent regulation of proenkephalin by JunD and JunB: positive and negative effects of AP-1 proteins.

1991 • 151 citations

Activation of the inducible orphan receptor gene nur77 by serum growth factors: dissociation of immediate-early and delayed-early responses.

1993 • 138 citations

Functional domains and phosphorylation of the orphan receptor Nur77.

1993 • 128 citations

Nur77 Is Differentially Modified in PC12 Cells upon Membrane Depolarization and Growth Factor Treatment

1991 • 108 citations

Corticotropin-releasing factor activates c-fos, NGFI-B, and corticotropin-releasing factor gene expression within the paraventricular nucleus of the rat hypothalamus.

1993 • 104 citations

Genes induced by serum growth factors

1991 • 97 citations

Expression of the nerve growth factor-regulated NGFI-A and NGFI-B genes in the developing rat

1990 • 93 citations

Growth factor-induced gene expression: the ups and downs of c-fos regulation.

1990 • 88 citations

Two adjacent promoter elements mediate nerve growth factor activation of the c-fos gene and bind distinct nuclear complexes.

1988 • 79 citations

Transcriptional activation of the inducible nuclear receptor gene nur77 by nerve growth factor and membrane depolarization in PC12 cells.

1993 • 78 citations

Transcriptional Activation by Nur77, a Growth Factor-lnducible Member of the Steroid Hormone Receptor Superfamily

1991 • 76 citations

Trans-dominant negative mutants of Fos and Jun.

1990 • 66 citations

Primary Response Genes Induced By Growth Factors And Tumor Promoters

1991 • 61 citations

Functional analysis of an isolated fos promoter element with AP-1 site homology reveals cell type-specific transcriptional properties.

1990 • 53 citations

Corticotropin-releasing factor activates c-fos, NGFI-B, and corticotropin-releasing factor gene expression within the paraventricular nucleus of the rat hypothalamus

1993 • 53 citations

Nerve growth factor induces transcription of NGFIA through complex regulatory elements that are also sensitive to serum and phorbol 12-myristate 13-acetate.

1993 • 50 citations

Functional domains and phosphorylation of the orphan receptor Nur77

1993 • 47 citations

Inhibition of jun transformation by a mutated fos gene: design of an anti-oncogene.

1991 • 42 citations

The Orphan Nuclear Receptor NGFI-B Regulates Expression of the Gene Encoding Steroid 21-Hydroxylase

1993 • 42 citations

Signal convergence on protein kinase A as a molecular correlate of learning.

1991 • 37 citations

The NGFI-B Gene, a Transcriptionally Inducible Member of the Steroid Receptor Gene Superfamily: Genomic Structure and Expression in Rat Brain after Seizure Induction

1989 • 26 citations

Nerve growth factor induces transcription of NGFIA through complex regulatory elements that are also sensitive to serum and phorbol 12- myristate 13-acetate

1993 • 25 citations

Nerve growth factor transcriptional control of c-fos promoter transfected in cultured spinal sensory neurons.

1992 • 25 citations

Regulation of the Differentiation of PC12 Pheochromocytoma Cells

1989 • 16 citations