Patterning of the mesoderm in Xenopus: dose-dependent and synergistic effects of Brachyury and Pintallavis

Appendix G: In Situ Hybridization: An Improved Whole-Mount Method for Xenopus Embryos

1991 • 2,082 citations

Functional messenger RNAs are produced by SP6in vitrotranscription of cloned cDNAs

1984 • 1,533 citations

Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos

1992 • 1,176 citations

HNF-3β is essential for node and notochord formation in mouse development

1994 • 985 citations

Expression of a xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction

1991 • 980 citations

Mesoderm induction in early Xenopus embryos by heparin-binding growth factors

1987 • 953 citations

Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early xenopus embryo

1987 • 883 citations

Cloning of the T gene required in mesoderm formation in the mouse

1990 • 847 citations

Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid

1991 • 799 citations

The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo

1994 • 786 citations

The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo

1989 • 672 citations

Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A

1990 • 660 citations

The gradient morphogen bicoid is a concentration-dependent transcriptional activator

1989 • 655 citations

no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene

1994 • 628 citations

Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures

1990 • 600 citations

Genetic Switch

2008 • 590 citations

Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development

1992 • 573 citations

Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate

1990 • 508 citations

DVR-4 (Bone Morphogenetic Protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction

1992 • 488 citations

Responses of embryonic xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm

1992 • 486 citations

Processed Vg1 protein is an axial mesoderm inducer in xenopus

1993 • 417 citations

The Brachyury gene encodes a novel DNA binding protein.

1993 • 406 citations

The LIM domain-containing homeo box gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos.

1992 • 371 citations

Mesodermal induction in early amphibian embryos by activin A (erythroid differentiation factor)

1990 • 357 citations

Cell type-specific activation of actin genes in the early amphibian embryo

1984 • 354 citations

Monoclonal antibodies identify blastemal cells derived from dedifferentiating muscle in newt limb regeneration

1984 • 353 citations

Pintallavis, a gene expressed in the organizer and midline cells of frog embryos: involvement in the development of the neural axis

1992 • 332 citations

dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo.

1992 • 309 citations

The Brachyury gene encodes a novel DNA binding protein.

1993 • 308 citations

Development of the short‐tailed mutant in the house mouse

1935 • 305 citations

Expression of zebrafish goosecoid and no tail gene products in wild-type and mutant no tail embryos

1994 • 294 citations

Polarizing activity and retinoid synthesis in the floor plate of the neural tube

1990 • 292 citations

Dorsalization and neural induction: properties of the organizer in Xenopus laevis.

1983 • 267 citations

Mesodermal patterning by an inducer gradient depends on secondary cell–cell communication

1994 • 267 citations

A novel, activin-inducible, blastopore lip-specific gene of Xenopus laevis contains a fork head DNA-binding domain.

1992 • 236 citations

Activin-like factor from a Xenopus laevis cell line responsible for mesoderm induction

1990 • 235 citations

Inducing factors in Xenopus early embryos

1994 • 234 citations

Induction of the Xenopus organizer: expression and regulation of Xnot, a novel FGF and activin-regulated homeo box gene.

1993 • 234 citations

Ectopic mesoderm formation in Xenopus embryos caused by widespread expression of a Brachyury homologue

1992 • 228 citations

The biological effects of XTC-MIF: quantitative comparison with Xenopus bFGF

1990 • 220 citations

Immunohistochemical Analysis of the Brachyury Protein in Wild-Type and Mutant Mouse Embryos

1994 • 218 citations

Differential activation of Xenopus homeo box genes by mesoderm-inducing growth factors and retinoic acid.

1990 • 199 citations

The homeobox gene goosecoid controls cell migration in Xenopus embryos

1993 • 186 citations

Regional biosynthetic markers in the early amphibian embryo

1984 • 180 citations

Secretion and mesoderm-inducing activity of the TGF-beta-related domain of Xenopus Vg1.

1993 • 177 citations

Gastrulation movements provide an early marker of mesoderm induction in Xenopus laevis

1987 • 172 citations

Mesodermal Patterning by a Gradient of the Vertebrate Homeobox Gene goosecoid

1994 • 168 citations

Altered Pax gene expression in murine notochord mutants: the notochord is required to initiate and maintain ventral identity in the somite

1993 • 121 citations

Mesoderm-inducing factors in early vertebrate development.

1993 • 120 citations

Rescue of the tail defect of Brachyury mice.

1993 • 118 citations

Activin A induced expression of a fork head related gene in posterior chordamesoderm (notochord) of Xenopus laevis embryos

1992 • 114 citations

Specification of mesodermal pattern in Xenopus laevis by interactions between Brachyury, noggin and Xwnt-8.

1994 • 97 citations

Ectopic neural expression of a floor plate marker in frog embryos injected with the midline transcription factor Pintallavis.

1993 • 87 citations

Slow emergence of a multithreshold response to activin requires cell-contact-dependent sharpening but not prepattern

1994 • 78 citations

Slow emergence of a multithreshold response to activin requires cell-contact-dependent sharpening but not prepattern

1994 • 72 citations

Morphological differences in Xenopus embryonic mesodermal cells are specified as an early response to distinct threshold concentrations of activin

1994 • 52 citations

Analysis of gastrulation: different types of gastrulation movement are induced by different mesoderm-inducing factors in Xenopus laevis

1993 • 52 citations

The antimorphic nature of the Tc allele at the mouse T locus.

1988 • 43 citations

Ventrolateral regionalization of Xenopus laevis mesoderm is characterized by the expression of α-smooth muscle actin

1992 • 40 citations

Differential induction of regulatory genes during mesoderm formation inXenopus laevis embryos

1993 • 40 citations

Does the T gene determine the anteroposterior axis of a mouse embryo?

1990 • 25 citations