NGF regulates the PC12 cell cycle machinery through specific inhibition of the Cdk kinases and induction of cyclin D1

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Nerve growth factor.

1968 • 2,025 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1994 • 1,669 citations

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

1993 • 1,605 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Cyclin A is required at two points in the human cell cycle.

1992 • 1,380 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

1991 • 1,190 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

Functional identity of proliferating cell nuclear antigen and a DNA polymerase-δ auxiliary protein

1987 • 1,074 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

1992 • 1,023 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites.

1987 • 945 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2

1989 • 920 citations

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

1992 • 906 citations

Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells.

1985 • 888 citations

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.

1991 • 858 citations

Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

1994 • 798 citations

Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement

1988 • 786 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit

1993 • 778 citations

Cyclin activation of p34cdc2

1990 • 690 citations

Analysis of cell cycle-related gene expression in postmitotic neurons: Selective induction of cyclin D1 during programmed cell death

1994 • 576 citations

TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest

1993 • 544 citations

Dorsal Root Ganglion Neurons Are Destroyed by Exposure in Utero to Maternal Antibody to Nerve Growth Factor

1980 • 500 citations

EUKARYOTIC DNA POLYMERASES

1991 • 493 citations

The cell-cycle regulated proliferating cell nuclear antigen is required for SV40 DNA replication in vitro

1987 • 491 citations

Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase

1991 • 475 citations

Joining the complex: Cyclin-dependent kinase inhibitory proteins and the cell cycle

1994 • 460 citations

Cell Cycle-Dependent Regulation of Phosphorylation of the Human Retinoblastoma Gene Product

1989 • 457 citations

Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system

1993 • 453 citations

Cyclins and cyclin-dependent kinases: take your partners

1993 • 441 citations

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells

1989 • 439 citations

Sequential initiation of lagging and leading strand synthesis by two different polymerase complexes at the SV40 DNA replication origin

1990 • 430 citations

Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme.

1994 • 415 citations

Coordinated leading and lagging strand synthesis during SV40 DNA replication in vitro requires PCNA

1988 • 395 citations

Growth factor signaling: Where is the specificity?

1992 • 341 citations

Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A.

1992 • 331 citations

D-Type Cyclin-Dependent Kinase Activity in Mammalian Cells

1994 • 322 citations

Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation

1992 • 321 citations

The cdk2 kinase is required for the G1-to-S transition in mammalian cells.

1993 • 307 citations

Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase.

1991 • 304 citations

Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase.

1994 • 299 citations

Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts.

1994 • 296 citations

Alterations in the surface properties of cells responsive to nerve growth factor

1978 • 279 citations

Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts.

1992 • 277 citations

Nerve growth factor-induced alteration in the response of PC12 pheochromocytoma cells to epidermal growth factor

1981 • 262 citations

CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.

1994 • 260 citations

Nerve growth factor regulates tyrosine hydroxylase gene transcription through a nucleoprotein complex that contains c-Fos.

1990 • 247 citations

Purification and characterization of a novel proline-directed protein kinase from bovine brain.

1992 • 238 citations

Inhibition of granulocyte differentiation by G1 cyclins D2 and D3 but not D1.

1993 • 233 citations

A nerve growth factor-regulated messenger RNA encodes a new intermediate filament protein.

1988 • 232 citations

CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle.

1992 • 230 citations

Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2.

1992 • 230 citations

Phosphorylation of the retinoblastoma protein by cdk2.

1992 • 217 citations

The Nerve Growth Factor: Its Role in Growth, Differentiation and Function of the Sympathetic Adrenergic Neuron

1976 • 185 citations

Nerve growth factor induces protein-tyrosine phosphorylation.

1988 • 184 citations

Cell cycle-specific action of nerve growth factor in PC12 cells: differentiation without proliferation.

1989 • 176 citations

SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells.

1993 • 170 citations

Human cyclin D1 encodes a labile nuclear protein whose synthesis is directly induced by growth factors and suppressed by cyclic AMP

1993 • 157 citations

RB and Cdc2 expression in brain: correlations with 3H-thymidine incorporation and neurogenesis

1993 • 141 citations

Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides.

1991 • 131 citations

Nerve growth factor has both mitogenic and antimitogenic activity

1982 • 103 citations

Regulation of Cyclin D-Dependent Kinase 4 (cdk4) by cdk4-activating kinase

1994 • 96 citations

Characterization of intermediate filaments in PC12 cells

1987 • 92 citations

The expression of the neuronal intermediate filament protein peripherin in the rat embryo

1990 • 91 citations

Nerve growth factor-induced differentiation of PC12 cells: evaluation of changes in RNA and DNA metabolism

1981 • 86 citations

Downregulation of CDC2 upon terminal differentiation of neurons.

1991 • 86 citations

Nerve growth factor-induced reduction in epidermal growth factor responsiveness and epidermal growth factor receptors in PC12 cells: An aspect of cell differentiation

1979 • 84 citations

Activation of the p34 CDC2 protein kinase at the start of S phase in the human cell cycle.

1992 • 71 citations

Relationship Between the Nerve Growth Factor‐Regulated Clone 73 Gene Product and the 58‐Kilodalton Neuronal Intermediate Filament Protein (Peripherin)

1988 • 57 citations

Nerve growth factor-treated, neurite-bearing PC12 cells continue to synthesize DNA

1985 • 54 citations

Adenovirus 5 E1A proteins disrupt the neuronal phenotype and growth factor responsiveness of PC12 cells by a conserved region 1-dependent mechanism.

1993 • 48 citations

Differential expression of D type cyclins during neuronal maturation

1994 • 39 citations

SNT, a Differentiation-Specific Target of Neurotrophic Factor-Induced Tyrosine Kinase Activity in Neurons and PC12 Cells

1993 • 36 citations

MN20, a D2 cyclin found in brain, is implicated in neural differentiation

1994 • 36 citations

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport

1992 • 31 citations

Domains of E1A that bind p105Rb, p130, and p300 are required to block nerve growth factor-induced neurite growth in PC12 cells.

1993 • 22 citations

Eukaryotic DNA Polymerases

1991 • 21 citations

Increment of the Cyclin D1 mRNA Level in TPA-Treated Three Human Myeloid Leukemia Cell Lines: HEL, CMK, and HL-60 Cells

1993 • 17 citations