Tumor suppressor genes

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1999 • 4,973 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

1999 • 3,566 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

1997 • 3,234 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1998 • 2,427 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

The regulation of E2F by pRB-family proteins

1998 • 2,297 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization

1998 • 2,096 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

1997 • 1,695 citations

E-cadherin germline mutations in familial gastric cancer

1998 • 1,629 citations

A Matter of Life and Cell Death

1998 • 1,523 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Pten is essential for embryonic development and tumour suppression

1998 • 1,507 citations

A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 -Deficient Mice

1996 • 1,488 citations

Mutations of mitotic checkpoint genes in human cancers

1998 • 1,482 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN

1998 • 1,215 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

1998 • 1,097 citations

PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs

1999 • 1,091 citations

Direct control of the Forkhead transcription factor AFX by protein kinase B

1999 • 1,080 citations

Mutation ofPten/Mmac1in mice causes neoplasia in multiple organ systems

1999 • 941 citations

The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro

1999 • 914 citations

Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis

1998 • 901 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function

1999 • 834 citations

Stabilization of wild-type p53 by hypoxia-inducible factor 1α

1998 • 818 citations

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

1998 • 796 citations

Antioncogenes and human cancer.

1993 • 772 citations

Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase

1999 • 771 citations

Cell Surface Trafficking of Fas: A Rapid Mechanism of p53-Mediated Apoptosis

1998 • 752 citations

Tumor surveillance via the ARF–p53 pathway

1998 • 735 citations

Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1

1996 • 704 citations

Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

1998 • 677 citations

Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

1993 • 664 citations

Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition

1999 • 663 citations

Signal transduction through beta-catenin and specification of cell fate during embryogenesis.

1996 • 663 citations

Roles for Nkx3.1 in prostate development and cancer

1999 • 660 citations

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1997 • 648 citations

Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes

1998 • 603 citations

Pml is essential for multiple apoptotic pathways

1998 • 564 citations

Loss-of-Function Mutations in PPARγ Associated with Human Colon Cancer

1999 • 512 citations

Impaired Fas Response and Autoimmunity in Pten ^+/− Mice

1999 • 512 citations

BRCA1 Inhibition of Estrogen Receptor Signaling in Transfected Cells

1999 • 494 citations

Apoptosis and APC in colorectal tumorigenesis.

1996 • 491 citations

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors

1993 • 465 citations

Synergy Between Tumor Suppressor APC and the β-Catenin-Tcf4 Target Tcf1

1999 • 452 citations

Ras Enhances Myc Protein Stability

1999 • 452 citations

Diverse Signaling Pathways Activated by Growth Factor Receptors Induce Broadly Overlapping, Rather Than Independent, Sets of Genes

1999 • 450 citations

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

1998 • 445 citations

Binding of APC to the Human Homolog of the Drosophila Discs Large Tumor Suppressor Protein

1996 • 430 citations

Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc

1999 • 427 citations

Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways

1998 • 421 citations

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

1999 • 388 citations

bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

1997 • 371 citations

c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

1999 • 330 citations

Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system.

1996 • 325 citations

Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency

1998 • 319 citations

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.

1994 • 290 citations

Inherited Mutations in PTEN That Are Associated with Breast Cancer, Cowden Disease, and Juvenile Polyposis

1997 • 281 citations

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/−) mice

1998 • 278 citations

Epidermal Growth Factor Protects Epithelial Cells against Fas-induced Apoptosis

1999 • 257 citations

RB Regulates the Stability and the Apoptotic Function of p53 via MDM2

1999 • 255 citations

Fas Ligand: A Sensor for DNA Damage Critical in Skin Cancer Etiology

1999 • 254 citations

The von Hippel–Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

1998 • 244 citations

Modeling stochastic gene expression: Implications for haploinsufficiency

1998 • 244 citations

The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway.

1996 • 228 citations

Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway

1998 • 219 citations

Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins.

1996 • 207 citations

Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle

1999 • 201 citations

Malignant melanoma: modern black plague and genetic black box

1998 • 198 citations

Proteolysis and the G1-S transition: the SCF connection

1998 • 156 citations

Studies of neoplasia in the Min mouse1C57BL/6J Min/+ mice are available worldwide from The Jackson Laboratory, Bar Harbor, ME 04609, USA.1

1997 • 151 citations

The caspase-RB connection in cell death

1998 • 138 citations

Critical Role Played by Cyclin D3 in the MyoD-Mediated Arrest of Cell Cycle during Myoblast Differentiation

1999 • 137 citations

Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation

1999 • 135 citations

Traps to catch unwary oncogenes

1998 • 113 citations

Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins

1997 • 103 citations

Allelic imbalance, including deletion ofPTEN/MMAC1, at the Cowden disease locus on 10q22-23, in hamartomas from patients with cowden syndrome and germlinePTEN mutation

1998 • 97 citations

pRb and E2f-1 in mouse development and tumorigenesis

1999 • 69 citations

A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in Apc ^Min /+ mice

1998 • 62 citations