Initiation, establishment and maintenance of Hox gene expression patterns in the mouse.

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Homeobox genes and axial patterning

1992 • 2,688 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

1999 • 1,549 citations

The origin of pattern and polarity in the Drosophila embryo

1992 • 1,367 citations

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo

1995 • 1,175 citations

A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

1993 • 1,086 citations

Embryonic retinoic acid synthesis is essential for early mouse post-implantation development

1999 • 1,051 citations

An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

1998 • 1,048 citations

The murine and Drosophila homeobox gene complexes have common features of organization and expression

1989 • 1,021 citations

Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid

1991 • 1,007 citations

The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes.

1989 • 912 citations

Requirement for Wnt3 in vertebrate axis formation

1999 • 882 citations

Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless

1998 • 869 citations

Clonal analysis of epiblast fate during germ layer formation in the mouse embryo

1991 • 865 citations

Hox genes and the evolution of vertebrate axial morphology

1995 • 825 citations

Fossils, genes and the evolution of animal limbs

1997 • 796 citations

A mouse model of Greig cephalo–polysyndactyly syndrome: the extra–toesJ mutation contains an intragenic deletion of the Gli3 gene

1993 • 715 citations

Homeosis and intestinal tumours in Cdx2 mutant mice

1997 • 670 citations

Temporal colinearity and the phylotypic progression: a basis for the stability of a vertebrate Bauplan and the evolution of morphologies through heterochrony

1994 • 631 citations

Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation

1989 • 612 citations

Molecular Models for Vertebrate Limb Development

1997 • 592 citations

Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain

1989 • 566 citations

Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells

1990 • 524 citations

A molecular gradient in early Drosophila embryos and its role in specifying the body pattern

1986 • 504 citations

Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx

1995 • 493 citations

The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster

1998 • 481 citations

Colinearity and functional hierarchy among genes of the homeotic complexes

1994 • 450 citations

A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1

1994 • 446 citations

Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development

1997 • 428 citations

Altered control of cellular proliferation in the absence of mammalian brahma (SNF2α)

1998 • 421 citations

A group of genes controlling the spatial expression of the bithorax complex in Drosophila

1985 • 413 citations

The Trithorax-like gene encodes the Drosophila GAGA factor

1994 • 409 citations

Expression of Cdx‐2 in the mouse embryo and placenta: Possible role in patterning of the extra‐embryonic membranes

1995 • 407 citations

The Drosophila Polycomb Group Gene pleiohomeotic Encodes a DNA Binding Protein with Homology to the Transcription Factor YY1

1998 • 400 citations

The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor

1994 • 391 citations

The formation of mesodermal tissues in the mouse embryo during gastrulation and early organogenesis

1987 • 379 citations

Polycombing the Genome: PcG, trxG, and Chromatin Silencing

1998 • 352 citations

Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes

1995 • 350 citations

Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body.

1991 • 344 citations

In vivo functional analysis of the Hoxa-1 3′ retinoic acid response element (3′ RARE)

1997 • 333 citations

Homeobox gene expression correlated with the bifurcation process of limb cartilage development

1991 • 317 citations

Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch

1998 • 317 citations

Hox gene expression in teleost fins and the origin of vertebrate digits

1995 • 315 citations

Genetic interactions betweenHoxa1andHoxb1reveal new roles in regulation of early hindbrain patterning

1998 • 311 citations

Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm

1990 • 300 citations

The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation

1993 • 297 citations

MLL, a mammalian trithorax- group gene, functions as a transcriptional maintenance factor in morphogenesis

1998 • 295 citations

Shaping animal body plans in development and evolution by modulation of Hox expression patterns

1998 • 295 citations

eFGF, Xcad3 and Hox genes form a molecular pathway that establishes the anteroposterior axis in Xenopus

1996 • 285 citations

Role of a Conserved Retinoic Acid Response Element in Rhombomere Restriction of Hoxb-1

1994 • 281 citations

Initiation of Rhombomeric Hoxb4 Expression Requires Induction by Somites and a Retinoid Pathway

1998 • 275 citations

Positive cross-regulation and enhancer sharing: two mechanisms for specifying overlapping Hox expression patterns.

1997 • 272 citations

Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation.

1995 • 268 citations

Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice

1997 • 266 citations

A role for mel-18, a Polycomb group-related vertebrate gene, during the anteroposterior specification of the axial skeleton

1996 • 256 citations

Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures

1994 • 245 citations

Gene Transpositions in the HoxD Complex Reveal a Hierarchy of Regulatory Controls

1996 • 226 citations

Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos

1998 • 225 citations

PcG complexes and chromatin silencing

1997 • 218 citations

Hox9 genes and vertebrate limb specification

1997 • 214 citations

Segment-specific expression of a homoeobox-containing gene in the mouse hindbrain

1989 • 214 citations

The distribution of endogenous retinoic acid in the chick embryo: implications for developmental mechanisms

1998 • 204 citations

Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1.

1997 • 203 citations

Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila

1995 • 202 citations

Activation of posterior gap gene expression in the Drosophila blastoderm

1995 • 201 citations

Functions of mammalian Polycomb group and trithorax group related genes

1997 • 199 citations

The Polycomb-group gene eed is required for normal morphogenetic movements during gastrulation in the mouse embryo

1998 • 198 citations

Polydactyly and ectopic ZPA formation in Alx-4 mutant mice

1997 • 196 citations

Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects

1997 • 196 citations

Hoxa2 and Hoxb2 Control Dorsoventral Patterns of Neuronal Development in the Rostral Hindbrain

1999 • 195 citations

Reprogramming Hox Expression in the Vertebrate Hindbrain: Influence of Paraxial Mesoderm and Rhombomere Transposition

1996 • 193 citations

Regulation of Hox gene expression and posterior development by the Xenopus caudal homologue Xcad3

1998 • 190 citations

A duplicated zone of polarizing activity in polydactylous mouse mutants.

1995 • 189 citations

Segmental expression of Hoxa-2 in the hindbrain is directly regulated by Krox-20

1996 • 188 citations

Mouse Cdx-1 expression during gastrulation

1993 • 187 citations

The kreisler mouse: a hindbrain segmentation mutant that lacks tworhombomeres

1994 • 184 citations

Binding of Trithorax and Polycomb proteins to the bithorax complex: dynamic changes during early Drosophila embryogenesis

1998 • 179 citations

The vertebrate limb: A model system to study the Hox/hom gene network during development and evolution

1992 • 175 citations

A cell lineage analysis of segmentation in the chick embryo

1988 • 174 citations

Clonal Analysis of Cell Fate During Gastrulation and Early Neurulation in the Mouse

2007 • 172 citations

Murine Cdx-4 bears striking similarities to the Drosophila caudal gene in its homeodomain sequence and early expression pattern

1993 • 169 citations

Selectivity, sharing and competitive interactions in the regulation of Hoxb genes

1998 • 167 citations

Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt)

1992 • 164 citations

Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond.

1997 • 163 citations

Plasticity of transposed rhombomeres: Hox gene induction is correlated with phenotypic modifications

1995 • 160 citations

Vertebrate Hox gene regulation: clustering and/or colinearity?

1998 • 159 citations

Transducing positional information to the Hox genes: critical interaction of cdx gene products with position-sensitive regulatory elements

1998 • 158 citations

Limbs: a model for pattern formation within the vertebrate body plan

1996 • 155 citations

Mouse homeobox gene transcripts occupy different but overlapping domains in embryonic germ layers and organs: a comparison of Hox-3.1 and Hox-1.5

1988 • 152 citations

Breaking Colinearity in the Mouse HoxD Complex

1999 • 148 citations

Segmental regulation of Hoxb-3 by kreisler

1997 • 145 citations

An early marker of axial pattern in the chick embryo and its respecification by retinoic acid

1992 • 142 citations

Chromatin-silencing mechanisms in Drosophila maintain patterns of gene expression

1997 • 137 citations

Segmental and neuronal architecture of the hindbrain of Krox-20 mouse mutants

1997 • 137 citations

Caudal is the Hox gene that specifies the most posterior Drosophile segment

1999 • 136 citations

The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression

1996 • 135 citations

The caudal gene product is a direct activator of fushi tarazu transcription during Drosophila embryogenesis

1989 • 133 citations

Conserved and distinct roles of kreisler in regulation of the paralogous Hoxa3 and Hoxb3 genes

1999 • 121 citations

The Drosophila trithorax protein binds to specific chromosomal sites and is co-localized with Polycomb at many sites.

1995 • 118 citations

Conservation in the Hox code during morphological evolution.

1994 • 117 citations

The trithorax group gene osa encodes an ARID-domain protein that genetically interacts with the Brahma chromatin-remodeling factor to regulate transcription

1999 • 117 citations

Homeotic gene expression in the locustSchistocerca: An antibody that detects conserved epitopes in ultrabithorax and abdominal‐A proteins

1994 • 115 citations

Differential expression of bithorax complex genes in the absence of the extra sex combs and trithorax genes

1983 • 114 citations

Fins, limbs, and tails: outgrowths and axial patterning in vertebrate evolution

1998 • 112 citations

Retinoid signaling is required for the establishment of a ZPA and for the expression of Hoxb-8, a mediator of ZPA formation

1997 • 109 citations

An imprinting element from the mouse H19 locus functions as a silencer in Drosophila

1997 • 106 citations

A caudal homologue in the short germ band beetle Tribolium shows similarities to both, the Drosophila and the vertebrate caudal expression patterns

1998 • 106 citations

Two Phases in the Establishment of HOX Expression Domains

1993 • 105 citations

Expression of the murine Hoxa4 gene requires both autoregulation and a conserved retinoic acid response element

1998 • 104 citations

The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development

1998 • 100 citations

Neuroectodermal fate of epiblast cells in the distal region of the mouse egg cylinder: implication for body plan organization during early embryogenesis

1995 • 99 citations

The chicken caudal genes establish an anterior-posterior gradient by partially overlapping temporal and spatial patterns of expression

1997 • 98 citations

Ectopic expression of homeotic genes caused by the elimination of the Polycomb gene in Drosophila imaginal epidermis

1988 • 98 citations

Polydactylous limbs in Strong’s Luxoid mice result from ectopic polarizing activity

1995 • 97 citations

Hox gene induction in the neural tube depends on three parameters: competence, signal supply and paralogue group

1997 • 92 citations

Temporal colinearity in expression of anterior hox genes in developing chick embryos

1996 • 89 citations

Genetic interactions of Hox genes in limb development: learning from compound mutants

1997 • 86 citations

Propagating memory of transcriptional states

1995 • 85 citations

Genetic interactions and dosage effects of Polycomb group genes in mice

1998 • 84 citations

Genes involved in the activation of the bithorax complex ofDrosophila

1981 • 84 citations

Zygotic caudal regulation by hunchback and its role in abdominal segment formation of the Drosophila embryo

1995 • 83 citations

Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity

1999 • 80 citations

Prospective fate map of the mouse primitive streak at 7.5 days of gestation

1994 • 78 citations

Regulation of the Tribolium homologues of caudal and hunchback in Drosophila: evidence for maternal gradient systems in a short germ embryo

1998 • 78 citations

Control of Colinearity in AbdB Genes of the Mouse HoxD Complex

1998 • 78 citations

Effects of ectopic expression of caudal during Drosophila development

1990 • 77 citations

Hoxb-2 transcriptional activation in rhombomeres 3 and 5 requires an evolutionarily conserved cis-acting element in addition to the Krox-20 binding site.

1996 • 75 citations

A molecular approach to the evolution of vertebrate paired appendages

1996 • 68 citations

Forward spreading in the establishment of a vertebrate Hox expression boundary: The expression domain separates into anterior and posterior zones, and the spread occurs across implanted glass barriers

1994 • 67 citations

The extra sex combs product contains WD40 repeats and its time of action implies a role distinct from other Polycomb group products

1995 • 66 citations

Evidence for two distinct retinoic acid response pathways for HOXB1 gene regulation.

1995 • 65 citations

The spatial and temporal distribution of polarizing activity in the flank of the pre-limb-bud stages in the chick embryo

1991 • 65 citations

Hox gene expression in a single Caenorhabditis elegans cell is regulated by a caudal homolog and intercellular signals that inhibit Wnt signaling

1999 • 64 citations

Hoxb-8 has a role in establishing early anterior-posterior polarity in chick forelimb but not hindlimb

1997 • 58 citations

HoxGene Expression in Limbs: Colinearity by Opposite Regulatory Controls

1999 • 55 citations

Elements both 5′ and 3′ to the murine Hoxd4 gene establish anterior borders of expression in mesoderm and neurectoderm

1997 • 54 citations

Altered Retinoic Acid Sensitivity and Temporal Expression of Hox Genes in Polycomb-M33-Deficient Mice

2000 • 53 citations

Hox genes and serial homology

1993 • 53 citations

Evolutionary shifts of vertebrate structures and Hox expression up and down the axial series of segments: a consideration of possible mechanisms.

2000 • 52 citations

Regulation of the Hoxb-8 Gene: Synergism between Multimerized cis-Acting Elements Increases Responsiveness to Positional Information

1995 • 49 citations

A long-range regulatory element of Hoxc8 identified by using the pClasper vector.

1996 • 49 citations

TheamnGene Product Is Required in Extraembryonic Tissues for the Generation of Middle Primitive Streak Derivatives

1998 • 48 citations

Organization and Development of Facial Motor Neurons in the Kreisler Mutant Mouse

1997 • 46 citations

Evidence that Hoxa expression domains are evolutionarily transposed in spinal ganglia, and are established by forward spreading in paraxial mesoderm

1999 • 29 citations

A 3' remote control region is a candidate to modulate Hoxb-8 expression boundaries.

1997 • 17 citations

A Proline-Rich Region in the Zeste Protein Essential for Transvection and white Repression by Zeste1

1998 • 15 citations