Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts.

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Mammalian G1 cyclins

1993 • 1,990 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Cyclin/PCNA is the auxiliary protein of DNA polymerase-δ

1987 • 1,766 citations

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

1993 • 1,605 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

A novel cyclin encoded by a bcl1-linked candidate oncogene

1991 • 1,286 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

1991 • 1,190 citations

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

1989 • 1,114 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

Functional identity of proliferating cell nuclear antigen and a DNA polymerase-δ auxiliary protein

1987 • 1,074 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

1993 • 1,057 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites.

1987 • 945 citations

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

1992 • 906 citations

Association of human cyclin E with a periodic G1-S phase protein kinase

1992 • 900 citations

Cyclin a is required for the onset of DNA replication in mammalian fibroblasts

1991 • 884 citations

Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast

1991 • 846 citations

Proliferating cell nuclear antigen is required for DNA excision repair

1992 • 809 citations

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

1993 • 799 citations

Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

1994 • 798 citations

Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement

1988 • 786 citations

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit

1993 • 778 citations

Cyclin-Dependent Regulation of G ₁ in Mammalian Fibroblasts

1993 • 767 citations

Saccharomyces cerevisiae cell cycle

1974 • 747 citations

Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA) structural conservation and the detection of a nucleolar form

1990 • 736 citations

cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF

1989 • 666 citations

Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system.

1994 • 659 citations

Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family

1991 • 656 citations

TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest

1993 • 544 citations

Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation

1994 • 543 citations

Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.

1993 • 514 citations

Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes

1991 • 493 citations

The cell-cycle regulated proliferating cell nuclear antigen is required for SV40 DNA replication in vitro

1987 • 491 citations

Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts.

1989 • 481 citations

Function of a human cyclin gene as an oncogene.

1994 • 471 citations

Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system

1993 • 453 citations

Inhibition of Cellular Proliferation by Antisense Oligodeoxynucleotides to PCNA Cyclin

1988 • 425 citations

A Link Between Cyclin A Expression and Adhesion-Dependent Cell Cycle Progression

1993 • 399 citations

Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression.

1993 • 393 citations

Reversal of terminal differentiation and control of DNA replication: Cyclin A and cdk2 specifically localize at subnuclear sites of DNA replication

1993 • 389 citations

Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes.

1993 • 362 citations

Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts.

1993 • 325 citations

Pulling springs to tune transduction: Adaptation by hair cells

1994 • 323 citations

G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment

1991 • 319 citations

The cdk2 kinase is required for the G1-to-S transition in mammalian cells.

1993 • 307 citations

Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells

1992 • 298 citations

Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression.

1993 • 295 citations

Cell Cycle Control of DNA Replication by a Homologue from Human Cells of the p34 ^cdc2 Protein Kinase

1990 • 285 citations

Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression.

1994 • 280 citations

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1.

1994 • 279 citations

Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts.

1992 • 277 citations

Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes.

1993 • 277 citations

Cyclin A is required in S phase in normal epithelial cells

1992 • 273 citations

cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication.

1992 • 272 citations

A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells

1989 • 262 citations

CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.

1994 • 260 citations

Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines.

1994 • 260 citations

Studies on the activator 1 protein complex, an accessory factor for proliferating cell nuclear antigen-dependent DNA polymerase delta.

1991 • 254 citations

Changes in cyclin/proliferating cell nuclear antigen distribution during DNA repair synthesis.

1988 • 248 citations

Independent regulation of human D-type cyclin gene expression during G1 phase in primary human T lymphocytes.

1993 • 247 citations

Association of cdk2 Kinase with the Transcription Factor E2F During S Phase

1992 • 239 citations

Cyclin D and oncogenesis

1993 • 233 citations

Oncogenic activity of cyclin D1 revealed through cooperation with Ha-ras: link between cell cycle control and malignant transformation.

1994 • 219 citations

A cdc2-like protein is involved in the initiation of DNA replication in Xenopus egg extracts

1990 • 209 citations

Synthesis of DNA by DNA polymerase epsilon in vitro.

1991 • 204 citations

Both cyclin A delta 60 and B delta 97 are stable and arrest cells in M-phase, but only cyclin B delta 97 turns on cyclin destruction.

1991 • 196 citations

Cyclin (PCNA, auxiliary protein of DNA polymerase δ) is a central component of the pathway(s) leading to DNA replication and cell division

1987 • 190 citations

Increased nuclear cyclin/PCNA antigen staining of non S‐phase transformed human amnion cells engaged in nucleotide excision DNA repair

1986 • 172 citations

Human cyclin D1 encodes a labile nuclear protein whose synthesis is directly induced by growth factors and suppressed by cyclic AMP

1993 • 157 citations

Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene.

1992 • 150 citations

The ins and outs of RB: coupling gene expression to the cell cycle clock

1994 • 137 citations

Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts

1993 • 131 citations

Localization of Cyclin A at the Sites of Cellular DNA Replication

1993 • 112 citations

Performance of an automated system for capillary microinjection into living cells

1988 • 98 citations

Growth factor regulation of cyclin D1 mRNA expression through protein synthesis-dependent and -independent mechanisms.

1993 • 96 citations

Recognition of the adenovirus type 2 origin of DNA replication by the virally encoded DNA polymerase and preterminal proteins.

1992 • 93 citations

Differential effect of ionizing radiation on the expression of cyclin A and cyclin B in HeLa cells.

1993 • 88 citations

D-type cyclin-binding regions of proliferating cell nuclear antigen

1994 • 88 citations

The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2

1993 • 80 citations

Novel Mammalian Cyclins (CYL Genes) Expressed during G1

1991 • 66 citations

Down-regulation of cell cycle control genes by ionizing radiation.

1992 • 57 citations

Cell Cycle — Materials and Methods

1996 • 53 citations

Exploring the Role of Drosophila Cyclin A in the Regulation of S Phase

1991 • 47 citations

Re-expression of senescent markers in deinduced reversibly immortalized cells

1992 • 39 citations

Association of p34cdc with Replicating DNA

1991 • 30 citations

Phosphorylation of Replication Protein A: A Role for cdc2 Kinase in G1/S Regulation

1991 • 28 citations