Arrest of G₁-S Progression by the p53-Inducible Gene PC3 Is Rb Dependent and Relies on the Inhibition of Cyclin D1 Transcription

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Cancer Cell Cycles

1996 • 5,379 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells

2005 • 2,216 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Cyclin/PCNA is the auxiliary protein of DNA polymerase-δ

1987 • 1,766 citations

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

1993 • 1,605 citations

Cyclin A is required at two points in the human cell cycle.

1992 • 1,380 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

1995 • 1,193 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

Functional identity of proliferating cell nuclear antigen and a DNA polymerase-δ auxiliary protein

1987 • 1,074 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes

1998 • 1,058 citations

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

1993 • 1,057 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

1992 • 1,023 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

D-type cyclins

1995 • 978 citations

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

1995 • 959 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

A family of human cdc2-related protein kinases.

1992 • 928 citations

Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2

1989 • 920 citations

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

1992 • 906 citations

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

1995 • 865 citations

Proliferating cell nuclear antigen is required for DNA excision repair

1992 • 809 citations

Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

1994 • 798 citations

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit

1993 • 778 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway.

1997 • 747 citations

Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation

1993 • 734 citations

The p53 Network

1998 • 731 citations

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

1994 • 731 citations

p21-containing cyclin kinases exist in both active and inactive states.

1994 • 646 citations

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

1994 • 617 citations

Negative Regulation of G1 in Mammalian Cells: Inhibition of Cyclin E-Dependent Kinase by TGF-β

1993 • 578 citations

TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest

1993 • 544 citations

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

1993 • 531 citations

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

1988 • 470 citations

Different Roles for Cyclins D1 and E in Regulation of the G₁-to-S Transition

1995 • 469 citations

Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F

1997 • 468 citations

Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs.

1996 • 446 citations

Induction of cellular p53 activity by DNA-damaging agents and growth arrest.

1993 • 440 citations

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells

1989 • 439 citations

The Mammalian Immediate-early TIS21 Protein and the Leukemia-associated BTG1 Protein Interact with a Protein-arginine -Methyltransferase

1996 • 435 citations

Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium

1978 • 431 citations

Identification of BTG2, an antiproliferative p53–dependent component of the DNA damage cellular response pathway

1996 • 416 citations

Identification of a growth suppression domain within the retinoblastoma gene product.

1992 • 413 citations

Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation.

1997 • 396 citations

The retinoblastoma protein pathway and the restriction point

1996 • 392 citations

Control of pRB phosphorylation

1998 • 389 citations

Cyclin E-induced S phase without activation of the pRb/E2F pathway.

1997 • 381 citations

Cyclin D1 Is Dispensable for G₁ Control in Retinoblastoma Gene-Deficient Cells Independently of cdk4 Activity

1995 • 370 citations

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

1997 • 359 citations

DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control

1994 • 323 citations

D-Type Cyclin-Dependent Kinase Activity in Mammalian Cells

1994 • 322 citations

Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc.

1996 • 319 citations

Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle.

1996 • 305 citations

Altered Cell Cycle Kinetics, Gene Expression, and G₁ Restriction Point Regulation in Rb-Deficient Fibroblasts

1996 • 301 citations

BTG1, a member of a new family of antiproliferative genes.

1992 • 298 citations

pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis.

1996 • 298 citations

Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts.

1994 • 296 citations

Induction of cyclin D1 overexpression by activated ras.

1994 • 295 citations

Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation.

1994 • 286 citations

Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression.

1994 • 280 citations

The Retinoblastoma Protein: A Master Regulator of Cell Cycle, Differentiation and Apoptosis

1997 • 250 citations

Activation of human cyclin-dependent kinases in vitro.

1992 • 242 citations

Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation.

1995 • 237 citations

Cyclin D1 expression is regulated by the retinoblastoma protein.

1994 • 235 citations

Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4.

1994 • 231 citations

CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle.

1992 • 230 citations

Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons.

1992 • 221 citations

Identification of G₁ Kinase Activity for cdk6, a Novel Cyclin D Partner

1994 • 213 citations

The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively

1998 • 207 citations

Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins

1997 • 206 citations

The Retinoblastoma Protein: More than a Tumor Suppressor

1994 • 205 citations

Expression of the antiproliferative gene TIS21 at the onset of neurogenesis identifies single neuroepithelial cells that switch from proliferative to neuron-generating division

1999 • 203 citations

A Predictive Scale for Evaluating Cyclin-dependent Kinase Substrates

1996 • 201 citations

Cloning and characterization of murine p16INK4a and p15INK4b genes.

1995 • 197 citations

Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity.

1996 • 190 citations

Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization.

1991 • 185 citations

A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor

1997 • 179 citations

Cell cycle-specific action of nerve growth factor in PC12 cells: differentiation without proliferation.

1989 • 176 citations

Structure and expression of TIS21, a primary response gene induced by growth factors and tumor promoters

1991 • 166 citations

p16^INK4A Participates in a G₁ Arrest Checkpoint in Response to DNA Damage

1998 • 163 citations

Inhibition of Cyclin D1 Kinase Activity Is Associated with E2F-Mediated Inhibition of Cyclin D1 Promoter Activity through E2F and Sp1

1998 • 160 citations

Nerve Growth Factor Induces Transcription of the p21 WAF1/CIP1 and Cyclin D1 Genes in PC12 Cells by Activating the Sp1 Transcription Factor

1997 • 156 citations

p53, through p21 (WAF1/CIP1), induces cyclin D1 synthesis.

1995 • 155 citations

Interaction of adenoviral proteins with pRB and p53

1993 • 134 citations

Suppression of a new allele of the yeast RAD52 gene by overexpression of RAD51, mutations in srs2 and ccr4, or mating-type heterozygosity.

1995 • 133 citations

Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein

1997 • 131 citations

Interaction of BTG1 and p53-regulatedBTG2 Gene Products with mCaf1, the Murine Homolog of a Component of the Yeast CCR4 Transcriptional Regulatory Complex

1998 • 125 citations

Subtractive Cloning and Characterization of DRAL, a Novel LIM-Domain Protein Down-Regulated in Rhabdomyosarcoma

1997 • 120 citations

ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system

1998 • 107 citations

DBF2, a cell cycle-regulated protein kinase, is physically and functionally associated with the CCR4 transcriptional regulatory complex

1997 • 106 citations

Early gene regulation by nerve growth factor in PC12 cells: induction of an interferon-related gene.

1989 • 103 citations

The analysis and interpretation of DNA distributions measured by flow cytometry

1982 • 98 citations

A procedure to standardize CAT reporter gene assay

1992 • 88 citations

Overexpression of the nerve growth factor-inducible PC3 immediate early gene is associated with growth inhibition.

1996 • 85 citations

Regulation of MyoD gene transcription and protein function by the transforming domains of the adenovirus E1A oncoprotein.

1993 • 83 citations

Cell Cycle and Cancer: Critical Events at the G1 Restriction Point

1996 • 78 citations

Induction of growth inhibition of 293 cells by downregulation of the cyclin E and cyclin-dependent kinase 4 proteins due to overexpression of TIS21

1998 • 72 citations

Analysis of two cDNA clones encoding the B lymphocyte antigen CD20 (B1, Bp35), a type III integral membrane protein.

1988 • 70 citations

Transcriptional control by the retinoblastoma protein

1995 • 69 citations

A novel expression assay to study transcriptional activators

1990 • 68 citations

Cyclin D1 and p21/waf1 are both involved in p53 growth suppression.

1996 • 68 citations

Transcriptional control of the cell cycle

1996 • 59 citations

Developmental expression of PC3 gene is correlated with neuronal cell birthday

1994 • 49 citations

Nerve growth factor regulates the subcellular localization of the nerve growth factor‐inducible protein PC4 in PC12 cells

1994 • 23 citations