Phosphatidylcholine breakdown and signal transduction

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

Protein kinase C isoenzymes: divergence in signal transduction?

1993 • 1,237 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

Molecular dissection of the secretory pathway

1992 • 985 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

1993 • 900 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2

1993 • 788 citations

Regulation of inositol phospholipid-specific phospholipase C isozymes.

1992 • 740 citations

The bioactive phospholipid lysophosphatidic acid is released from activated platelets

1993 • 653 citations

NMDA receptors activate the arachidonic acid cascade system in striatal neurons

1988 • 600 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C.

1993 • 521 citations

Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.

1987 • 472 citations

Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2

1991 • 447 citations

A calcium-dependent mechanism for associating a soluble arachidonoyl-hydrolyzing phospholipase A2 with membrane in the macrophage cell line RAW 264.7.

1990 • 447 citations

Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6

1991 • 442 citations

Tissue and cellular distribution of the extended family of protein kinase C isoenzymes

1992 • 441 citations

Function of Ras as a molecular switch in signal transduction.

1992 • 425 citations

Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin

1984 • 418 citations

Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism

1988 • 413 citations

The protein kinase C family

1992 • 399 citations

ADP-ribosylation of the specific membrane protein by islet-activating protein, pertussis toxin, associated with inhibition of a chemotactic peptide-induced arachidonate release in neutrophils. A possible role of the toxin substrate in Ca2+-mobilizing biosignaling.

1984 • 389 citations

Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.

1992 • 368 citations

Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC12 pheochromocytoma cells.

1992 • 355 citations

Phosphatidylethanol Formation via Transphosphatidylation by Rat Brain Synaptosomal Phospholipase D

1987 • 342 citations

Cellular ras activity and phospholipid metabolism

1988 • 331 citations

Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts

1987 • 330 citations

Identification of neutral active phospholipase C which hydrolyzes choline glycerophospholipids and plasmalogen selective phospholipase A2 in canine myocardium.

1985 • 315 citations

Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene

1987 • 303 citations

Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate.

1992 • 296 citations

Direct activation of purified protein kinase C by unsaturated fatty acids (oleate and arachidonate) in the absence of phospholipids and Ca²⁺

1985 • 293 citations

Activation of the c-Raf protein kinase by protein kinase C phosphorylation.

1992 • 288 citations

The Effect of GTPase Activating Protein Upon Ras Is Inhibited by Mitogenically Responsive Lipids

1989 • 287 citations

Plasma membrane fractions from rat liver contain a phosphatidate phosphohydrolase distinct from that in the endoplasmic reticulum and cytosol.

1991 • 271 citations

Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin

1992 • 266 citations

Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6.

1991 • 265 citations

Lysophosphatidic acid, but not phosphatidic acid, is a potent Ca2(+)-mobilizing stimulus for fibroblasts. Evidence for an extracellular site of action.

1990 • 264 citations

Phosphatidylcholine breakdown in rat liver plasma membranes. Roles of guanine nucleotides and P2-purinergic agonists.

1987 • 253 citations

G-protein-regulated phospholipases C, D and A2-mediated signalling in neutrophils.

1992 • 252 citations

Regulation of Phospholipase D in HL-60 Granulocytes

1989 • 250 citations

Signal transduction from cell surface to nucleus in development and disease

1992 • 246 citations

Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release in 3T3 fibroblasts. Selective susceptibility to islet-activating protein, pertussis toxin.

1985 • 245 citations

Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase.

1993 • 241 citations

Three distinct forms of rat brain protein kinase C: Differential response to unsaturated fatty acids

1987 • 239 citations

Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation-independent mechanism.

1992 • 237 citations

Stimulation of specific types of Gs-stimulated adenylyl cyclases by phorbol ester treatment.

1993 • 235 citations

Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts.

1993 • 234 citations

Choline-linked Phosphoglycerides

1989 • 234 citations

Neutrophil phospholipase D is activated by a membrane-associated Rho family small molecular weight GTP-binding protein.

1993 • 229 citations

The base exchange enzymes and phospholipase D of mammalian tissue

1980 • 226 citations

Phosphatidic acid may stimulate membrane receptors mediating adenylate cyclase inhibition and phospholipid breakdown in 3T3 fibroblasts.

1987 • 219 citations

Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide.

1993 • 213 citations

Kinetic analysis of 1,2-diacylglycerol mass levels in cultured fibroblasts. Comparison of stimulation by alpha-thrombin and epidermal growth factor.

1988 • 207 citations

Phospholipase D activation is functionally linked to superoxide generation in the human neutrophil

1989 • 204 citations

Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid.

1992 • 199 citations

C-protein-regulated phospholipases C, D and A2-mediated signalling in neutrophils

1992 • 198 citations

Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal.

1992 • 195 citations

Type-specific stimulation of adenylylcyclase by protein kinase C.

1993 • 187 citations

Light activation of phospholipase A2 in rod outer segments of bovine retina and its modulation by GTP-binding proteins.

1987 • 186 citations

The Many Roads That Lead to Ras

1993 • 185 citations

Activation of neutrophil leukocytes: chemoattractant receptors and respiratory burst ¹

1993 • 184 citations

Differential translocation of protein kinase C isozymes by thrombin and platelet-derived growth factor. A possible function for phosphatidylcholine-derived diacylglycerol

1993 • 182 citations

A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin

1993 • 179 citations

Purification of a high-molecular-mass form of phospholipase A2 from rat kidney activated at physiological calcium concentrations

1990 • 174 citations

Phospholipase D in cell signalling and its relationship to phospholipase C

1991 • 172 citations

Cytosolic and stored calcium antagonistically control tyrosine phosphorylation of specific platelet proteins.

1991 • 170 citations

Gonadotropin-releasing hormone activates phospholipase D in ovarian granulosa cells

1989 • 168 citations

Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effects on activation of NADPH oxidase.

1991 • 165 citations

Overexpression of protein kinase C isoenzymes alpha, beta I, gamma, and epsilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling.

1993 • 162 citations

ARF signaling: A potential role for phospholipase D in membrane traffic

1993 • 161 citations

Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil

1992 • 160 citations

Expression of four protein kinase C isoforms in rat fibroblasts. Distinct subcellular distribution and regulation by calcium and phorbol esters.

1992 • 160 citations

Different isozymes of protein kinase C mediate feedback inhibition of phospholipase C and stimulatory signals for exocytosis in rat RBL-2H3 cells.

1993 • 158 citations

Regulation of phospholipase A2 activation by phosphorylation in mouse peritoneal macrophages.

1993 • 158 citations

Raf-1: A kinase currently without a cause but not lacking in effects

1991 • 155 citations

Phosphatidic acid and not diacylglycerol generated by phospholipase D is functionally linked to the activation of the NADPH oxidase by FMLP in human neutrophils

1990 • 151 citations

Partial purification and properties of a rat brain phospholipase.

1979 • 149 citations

Thrombin and collagen induce rapid phosphorylation of a common set of cellular proteins on tyrosine in human platelets

1989 • 148 citations

Muscarinic Receptor Activation of Phosphatidylcholine Hydrolysis

1989 • 146 citations

Isolation of human eosinophil phospholipase D.

1976 • 139 citations

Peroxides of vanadate induce activation of phospholipase D in HL-60 cells. Role of tyrosine phosphorylation.

1992 • 139 citations

Activation of NADPH-dependent superoxide production in plasma membrane extracts of pig neutrophils by phosphatidic acid.

1988 • 138 citations

Stimulation of Phosphatidylcholine Hydrolysis, Diacylglycerol Release, and Arachidonic Acid Production by Oncogenic Ras Is a Consequence of Protein Kinase C Activation

1989 • 136 citations

Phosphatidic acid modulates DNA synthesis, phospholipase C, and platelet-derived growth factor mRNAs in cultured mesangial cells. Role of protein kinase C.

1990 • 134 citations

Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5'-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol.

1991 • 134 citations

Activation of the human neutrophil by calcium-mobilizing ligands. II. Correlation of calcium, diacyl glycerol, and phosphatidic acid generation with superoxide anion generation.

1988 • 133 citations

Kinetic properties of a high molecular mass arachidonoyl-hydrolyzing phospholipase A2 that exhibits lysophospholipase activity

1991 • 133 citations

Translocation of protein kinase C isozymes in thrombin-stimulated human platelets. Correlation with 1,2-diacylglycerol levels.

1992 • 130 citations

Epidermal growth factor enhances glomerular mesangial cell soluble phospholipase A2 activity.

1990 • 130 citations

Ca^{2 +}‐mobilizing hormones elicit phosphatidylethanol accumulation via phospholipase D activation

1987 • 130 citations

Tumor necrosis factor alpha priming of phospholipase D in human neutrophils

1991 • 129 citations

Properties of phospholipase C isolated from rat liver lysosomes.

1980 • 128 citations

Interleukin-1 generates transmembrane signals from phospholipids through novel pathways in cultured rat mesangial cells.

1989 • 128 citations

Protein kinase C heterogeneity in GH4C1 rat pituitary cells. Characterization of a Ca2(+)-independent phorbol ester receptor.

1990 • 126 citations

Purification of a phospholipase A2 from human monocytic leukemic U937 cells. Calcium-dependent activation and membrane association.

1990 • 125 citations

Differential regulation of protein kinase C isozymes by thyrotropin-releasing hormone in GH4C1 cells.

1991 • 124 citations

Fatty Acid Activation and Temperature Perturbation of Rat Brain Microsomal Phospholipase D

1982 • 121 citations

Existence of cytosolic phospholipase D. Identification and comparison with membrane-bound enzyme

1991 • 120 citations

Dissociation of protein kinase C activation and sn-1,2-diacylglycerol formation. Comparison of phosphatidylinositol- and phosphatidylcholine-derived diglycerides in alpha-thrombin-stimulated fibroblasts.

1991 • 120 citations

Angiotensin II stimulates protein-tyrosine phosphorylation in a calcium-dependent manner.

1990 • 118 citations

Bradykinin and bombesin rapidly stimulate tyrosine phosphorylation of a 120-kDa group of proteins in Swiss 3T3 cells.

1991 • 117 citations

Alpha 1-adrenergic receptors promote phosphatidylcholine hydrolysis in MDCK-D1 cells. A mechanism for rapid activation of protein kinase C.

1988 • 115 citations

Complement receptor-mediated phagocytosis is associated with accumulation of phosphatidylcholine-derived diglyceride in human neutrophils. Involvement of phospholipase D and direct evidence for a positive feedback signal of protein kinase.

1992 • 115 citations

Signalling properties of lysophosphatidic acid

1993 • 112 citations

v-Src increases diacylglycerol levels via a type D phospholipase-mediated hydrolysis of phosphatidylcholine.

1991 • 111 citations

Hormonal stimulation of diacylglycerol formation in hepatocytes.

1989 • 111 citations

Rapid protein kinase C-dependent activation of phospholipase D leads to delayed 1,2-diglyceride accumulation.

1990 • 110 citations

ATP stimulates the hydrolysis of phosphatidylethanolamine in NIH 3T3 cells. Potentiating effects of guanosine triphosphates and sphingosine.

1990 • 110 citations

An indirect pathway of receptor-mediated 1,2-diacylglycerol formation in mast cells. I. IgE receptor-mediated activation of phospholipase D.

1990 • 109 citations

A G Protein Mutant That Inhibits Thrombin and Purinergic Receptor Activation of Phospholipase A₂

1990 • 108 citations

Phosphatidohydrolase activity in a solubilized preparation from rat brain particulate fraction

1975 • 108 citations

The biologically active phospholipid, lysophosphatidic acid, induces phosphatidylcholine breakdown in fibroblasts via activation of phospholipase D. Comparison with the response to endothelin

1992 • 107 citations

Elevated phosphocholine concentration in ras-transformed NIH 3T3 cells arises from increased choline kinase activity, not from phosphatidylcholine breakdown.

1989 • 106 citations

Synergistic activation of phospholipase D by protein kinase C- and G-protein-mediated pathways in streptolysin O-permeabilized HL60 cells

1992 • 104 citations

Evidence for a role of phosphatidylcholine-hydrolysing phospholipase C in the regulation of protein kinase C by ras and src oncogenes.

1990 • 103 citations

Identification of phosphatidylcholine-selective and phosphatidylinositol-selective phospholipases D in Madin-Darby canine kidney cells.

1992 • 103 citations

Increases in phosphatidic acid levels accompany sphingosine-stimulated proliferation of quiescent Swiss 3T3 cells.

1990 • 103 citations

Phorbol myristate acetate (PMA) augments chemoattractant-induced diglyceride generation in human neutrophils but inhibits phosphoinositide hydrolysis. Implications for the mechanism of PMA priming of the respiratory burst.

1988 • 101 citations

Phospholipid metabolism in bradykinin-stimulated human fibroblasts. II. Phosphatidylcholine breakdown by phospholipases C and D; involvement of protein kinase C

1991 • 100 citations

A neutral phospholipase D activity from rat brain synaptic plasma membranes. Identification and partial characterization.

1990 • 100 citations

Antibodies prepared to Bacillus cereus phospholipase C crossreact with a phosphatidylcholine preferring phosoholipase C in mammalian cells

1986 • 97 citations

Histamine-stimulated and GTP-binding proteins-mediated phospholipase A2 activation in rabbit platelets.

1990 • 97 citations

Multiple sources of sn-1,2-diacylglycerol in platelet-derived-growth-factor-stimulated Swiss 3T3 fibroblasts. Evidence for activation of phosphoinositidase C and phosphatidylcholine-specific phospholipase D

1991 • 97 citations

Muscarinic acetylcholine receptor regulates phosphatidylcholine phospholipase D in canine brain

1989 • 96 citations

The tyrosine kinase activity of the epidermal-growth-factor receptor is necessary for phospholipase A2 activation

1990 • 95 citations

Activation of Protein Kinase C by Naturally Occurring Ether-linked Diglycerides

1989 • 91 citations

Activation of phospholipase D in a rat mast (RBL 2H3) cell line. A possible unifying mechanism for IgE-dependent degranulation and arachidonic acid metabolite release.

1991 • 91 citations

Phospholipase D in homogenates from HL-60 granulocytes: Implications of calcium and G protein control

1989 • 91 citations

Phorbol ester treatment of intact rabbit platelets greatly enhances both the basal and guanosine 5′-[γ-thio]triphosphate-stimulated phospholipase D activities of isolated platelet membranes. Physiological activation of phospholipase D may be secondary to activation of phospholipase C

1990 • 90 citations

Elevated cytosolic Ca2+ activates phospholipase D in human platelets

1991 • 90 citations

Epidermal growth factor increases sn-1,2-diacylglycerol levels and activates phospholipase D-catalysed phosphatidylcholine breakdown in Swiss 3T3 cells in the absence of inositol-lipid hydrolysis

1992 • 88 citations

Potentiation of diacylglycerol‐induced activation of protein kinase C by lysophospholipids

1993 • 88 citations

Stimulation of phosphatidylinositol 4,5-bisphosphate phospholipase C activity by phosphatidic acid

1989 • 88 citations

Dissociation of protein kinase C redistribution from the phosphorylation of its substrates

1991 • 87 citations

Second messenger function of phosphatidic acid in platelet activation

1989 • 86 citations

Alpha 2-C10 adrenergic receptors expressed in rat 1 fibroblasts can regulate both adenylylcyclase and phospholipase D-mediated hydrolysis of phosphatidylcholine by interacting with pertussis toxin-sensitive guanine nucleotide-binding proteins.

1992 • 84 citations

Up-regulation of phospholipase D activity induced by overexpression of protein kinase C-alpha. Studies in intact Swiss/3T3 cells and in detergent-solubilized membranes in vitro

1993 • 84 citations

The sustained second phase of hormone-stimulated diacylglycerol accumulation does not activate protein kinase C in GH3 cells.

1990 • 82 citations

Sphingosine activation of protein kinases in Jurkat T cells. In vitro phosphorylation of endogenous protein substrates and specificity of action.

1992 • 80 citations

Phospholipase D activity in phagocytic leucocytes is synergistically regulated by G-protein- and tyrosine kinase-based mechanisms

1993 • 78 citations

Functional divergence of protein kinase C (PKC) family members. PKC gamma differs from PKC alpha and -beta II and nPKC epsilon in its competence to mediate-12-O-tetradecanoyl phorbol 13-acetate (TPA)-responsive transcriptional activation through a TPA-response element.

1993 • 76 citations

Lysophosphatidic acid: A bioactive phospholipid with growth factor-like properties

1992 • 75 citations

Regulation of phospholipase D and primary granule secretion by P2-purinergic- and chemotactic peptide-receptor agonists is induced during granulocytic differentiation of HL-60 cells.

1991 • 73 citations

Differential regulation of phosphoinositide and phosphatidylcholine hydrolysis by protein kinase C-beta 1 overexpression. Effects on stimulation by alpha-thrombin, guanosine 5'-O-(thiotriphosphate), and calcium.

1992 • 72 citations

Mastoparan, a novel mitogen for Swiss 3T3 cells, stimulates pertussis toxin-sensitive arachidonic acid release without inositol phosphate accumulation.

1991 • 72 citations

Alpha 1-adrenergic receptor-mediated activation of phospholipase D in rat cerebral cortex.

1992 • 69 citations

Effects of sphingosine, albumin and unsaturated fatty acids on the activation and translocation of phosphatidate phosphohydrolases in rat hepatocytes

1992 • 69 citations

Rapid attenuation of receptor-induced diacylglycerol and phosphatidic acid by phospholipase D-mediated transphosphatidylation: formation of bisphosphatidic acid.

1993 • 68 citations

Protein tyrosine phosphorylation in rabbit peritoneal neutrophils

1990 • 68 citations

Stimulation of the hydrolysis of phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine by endothelin, a complete mitogen for Rat-1 fibroblasts

1990 • 68 citations

Synergistic activation of type III protein kinase C by cis-fatty acid and diacylglycerol

1992 • 66 citations

fMet-Leu-Phe-induced activation of phospholipase D in human neutrophils. Dependence on changes in cytosolic free Ca2+ concentration and relation with respiratory burst activation.

1991 • 66 citations

Isolation and properties of a phosphatidylcholine-specific phospholipase C from bull seminal plasma.

1986 • 64 citations

Evidence of GTP-binding protein regulation of phospholipase A2 activity in isolated human platelet membranes

1989 • 64 citations

Kinetic evidence of a rapid activation of phosphatidylcholine hydrolysis by Ki-ras oncogene. Possible involvement in late steps of the mitogenic cascade.

1990 • 64 citations

Phospholipase D mimics platelet-derived growth factor as a competence factor in vascular smooth muscle cells.

1992 • 63 citations

Differential activation by fMet‐Leu‐Phe and phorbol ester of a plasma membrane phosphatidylcholine‐specific phospholipase D in human neutrophil

1989 • 63 citations

Influence of calcium on the subcellular distribution of protein kinase C in human neutrophils

1989 • 62 citations

Regulation of arachidonate‐mobilizing phospholipase A₂ by phosphorylation via protein kinase C in macrophages

1992 • 62 citations

The regulation of phospholipase D activity and its role in sn-1,2-diradylglycerol formation in bombesin- and phorbol 12-myristate 13-acetate-stimulated Swiss 3T3 cells

1991 • 62 citations

Guanine-nucleotide- and adenine-nucleotide-dependent regulation of phospholipase D in electropermeabilized HL-60 granulocytes

1991 • 62 citations

The role of calcium and protein kinase C in the IgE‐dependent activation of phosphatidylcholine‐specific phospholipase D in a rat mast (RBL 2H3) cell line

1992 • 60 citations

Inhibition of expression of protein kinase C alpha by antisense cDNA inhibits phorbol ester-mediated arachidonate release

1993 • 59 citations

Hydrolysis of Phosphatidylcholine Is Stimulated by Ras Proteins during Mitogenic Signal Transduction

1992 • 59 citations

GTPγS and phorbol ester act synergistically to stimulate both Ca²⁺‐independent secretion and phospholipase D activity in permeabilized human platelets

1993 • 58 citations

Activation of NADPH oxidase and phospholipase D in permeabilized human neutrophils. Correlation between oxidase activation and phosphatidic acid production.

1992 • 58 citations

Differential sensitivity of arachidonic acid release and 1,2-diacylglycerol formation to pertussis toxin, GDP βS and NaF in saponin-permeabilized human platelets: possible evidence for distinct GTP-binding proteins involving phospholipase C and A2 activation

1987 • 58 citations

Lysophosphatidic acid induces inward currents in Xenopuslaevis oocytes; evidence for an extracellular site of action

1992 • 58 citations

Characterization and identification of an epidermal-growth-factor-activated phospholipase A2

1992 • 58 citations

Platelet-activating factor-stimulated protein tyrosine phosphorylation and eicosanoid synthesis in rat Kupffer cells. Evidence for calcium-dependent and protein kinase C-dependent and -independent pathways.

1992 • 57 citations

Effect of tumour-promoting phorbol ester, thrombin and vasopressin on translocation of three distinct protein kinase C isoforms in human platelets and regulation by calcium

1992 • 57 citations

Involvement of Protein Kinase C in Platelet-activating Factor-stimulated Diacylglycerol Accumulation in Murine Peritoneal Macrophages

1989 • 57 citations

A guanine nucleotide-binding protein participates in IgE receptor-mediated activation of endogenous and reconstituted phospholipase A2 in a permeabilized cell system.

1990 • 57 citations

Neurotransmitter Release from Lysophosphatidic Acid-Stimulated PC12 Cells: Involvement of Lysophosphatidic Acid Receptors

1993 • 57 citations

Stimulation of phosphatidylcholine breakdown and diacylglycerol production by growth factors in Swiss-3T3 cells

1989 • 56 citations

Stimulation of arachidonic acid release by guanine nucleotide in saponin-permeabilized neutrophils: Evidence for involvement of GTP-binding protein in phospholipase A2 activation

1988 • 56 citations

Synaptic plasticity: on the trail of the retrograde messenger

1992 • 55 citations

Stimulations of arachidonate release and inositol-1,4,5-triphosphate formation are mediated by distinct G-proteins in human platelets

1987 • 52 citations

Hydrolysis of phosphatidylcholine by phospholipase D is a common response to mitogens which stimulate inositol lipid hydrolysis in Swiss 3T3 fibroblasts

1991 • 51 citations

Divergent effects of propranolol on neutrophil superoxide release: Involvement of phosphatidic acid and diacylglycerol as second messengers

1991 • 49 citations

A protein kinase C inhibitor, staurosporine, activates phospholipase D via a pertussis toxin-sensitive GTP-binding protein in rabbit peritoneal neutrophils.

1992 • 49 citations

Differences in the regulation of endothelin-1- and lysophosphatidic-acid-stimulated Ins(1,4,5)P3 formation in rat-1 fibroblasts

1991 • 48 citations

Stimulation of phosphatidate synthesis in endothelial cells in response to P2-receptor activation. Evidence for phospholipase C and phospholipase D involvement, phosphatidate and diacylglycerol interconversion and the role of protein kinase C

1992 • 48 citations

Fibroblast growth factor stimulates protein kinase C in quiescent 3T3 cells without Ca²⁺ mobilization or inositol phosphate accumulation

1990 • 48 citations

Phorbol ester-stimulated hydrolysis of phosphatidylcholine and phosphatidylethanolamine by phospholipase D in HeLa cells. Evidence that the basal turnover of phosphoglycerides does not involve phospholipase D.

1991 • 47 citations

Evidence for coupling of bradykinin receptors to a guanine-nucleotide binding protein to stimulate arachidonate liberation in the osteoblast-like cell line, MC3T3-E1

1991 • 46 citations

Oleate stimulation of diacylglycerol formation from phosphatidylcholine through effects on phospholipase D and phosphatidate phosphohydrolase

1992 • 44 citations

Involvement of Tyrosine Phosphorylation in IgE Receptor-Mediated Phospholipase D Activation in Rat Basophilic Leukemia (RBL-2H3) Cells

1993 • 44 citations

Ca2+ inhibits guanine nucleotide-activated phospholipase D in neural-derived NG108-15 cells.

1991 • 43 citations

Differential pathways (phospholipase C and phospholipase D) of bradykinin-induced biphasic 1,2-diacylglycerol formation in non-transformed and K-ras-transformed NIH-3T3 fibroblasts. Involvement of intracellular Ca2+ oscillations in phosphatidylcholine breakdown

1992 • 43 citations

Relationship between arachidonate release and exocytosis in permeabilized human neutrophils stimulated with formylmethionyl-leucyl-phenylalanine (fMetLeuPhe), guanosine 5′-[γ-thio]triphosphate (GTP[S]) and Ca2+

1991 • 42 citations

Phosphatidic acid and lysophosphatidic acid stimulate receptor-regulated membrane currents in the Xenopus laevis oocyte

1992 • 42 citations

Epidermal growth factor stimulates phospholipase A2 in vasopressin-treated rat glomerular mesangial cells

1988 • 41 citations

Endothelin-1 activates phospholipase D and thymidine incorporation in fibroblasts overexpressing protein kinase C beta 1.

1991 • 41 citations

Endothelin stimulates phosphatidic acid formation in cultured rat mesangial cells: Role of a protein kinase C‐regulated phospholipase D

1992 • 41 citations

Rat brain cytosol contains a factor which reconstitutes guanine‐nucleotide‐binding‐protein‐regulated phospholipase‐D activation in HL60 cells previously permeabilized with streptolysin O

1993 • 41 citations

Metabolic conversion of the biologically active phospholipid, lysophosphatidic acid, in fibroblasts

1992 • 40 citations

Interleukin 3 stimulates phosphatidylcholine turnover in a mast/megakaryocyte cell line

1989 • 40 citations

Physical evidence for the presence of two forms of phosphatidate phosphohydrolase in rat liver

1992 • 39 citations

Activation of phospholipase D in rabbit neutrophils by fMet‐Leu‐Phe is mediated by a pertussis toxin‐sensitive GTP‐binding protein that may be distinct from a phospholipase C‐regulating protein

1991 • 38 citations

Differential effects of platelet-derived growth factor, serum and bombesin on phospholipase D-mediated hydrolysis of phosphatidylethanolamine in NIH 3T3 fibroblasts

1992 • 38 citations

Pertussis toxin-sensitive GTP-binding proteins may regulate phospholipase A2 in response to thrombin in rabbit platelets

1989 • 37 citations

Modulation of phospholipase A2 activity by epidermal growth factor (EGF) in CHO cells transfected with human EGF receptor. Role of receptor cytoplasmic subdomain

1991 • 37 citations

Evidence for the calcium-dependent activation of phospholipase D in thrombin-stimulated human erythroleukaemia cells

1990 • 36 citations

Direct relationship between intracellular calcium mobilization and phospholipase D activation in prostaglandin E-stimulated human erythroleukemia cells

1992 • 36 citations

Hydrolysis of phosphatidylcholine is stimulated by Ras proteins during mitogenic signal transduction.

1992 • 36 citations

Phospholipase D hydrolysis of choline phosphoglycerides is selective for the alkyl-linked subclass of Madin-Darby canine kidney cells.

1993 • 36 citations

Activation and solubilization by triton X‐100 of membrane‐bound phospholipase D of rat brain

1991 • 36 citations

Substrate specificity of neutral phospholipase D from rat brain studied by selective labeling of endogenous synaptic membrane phospholipids in vitro.

1992 • 35 citations

Long-term phorbol ester treatment dissociates phospholipase D activation from phosphoinositide hydrolysis and prostacyclin synthesis in endothelial cells stimulated with bradykinin

1989 • 35 citations

Guanine Nucleotide‐Binding Protein Regulation of Microsomal Phospholipase D Activity of Canine Cerebral Cortex

1990 • 33 citations

The roles of phospholipase D and a GTP-binding protein in guanosine 5′-[γ-thio]triphosphate-stimulated hydrolysis of phosphatidylcholine in rat liver plasma membranes

1990 • 32 citations

Tumor necrosis factor cytotoxicity is associated with phospholipase D activation

1993 • 32 citations

Human neutrophil phospholipase D activation by N-formylmethionyl-leucylphenylalanine reveals a two-step process for the control of phosphatidylcholine breakdown and oxidative burst

1992 • 32 citations

Effects of Phosphatidic Acid on Islet Cell Phosphoinositide Hydrolysis, Ca2+, and Adenylate Cyclase

1989 • 30 citations

Pertussis Toxin‐Insensitive G Protein Mediates Carbachol Activation of Phospholipase D in Rat Pheochromocytoma PC12 Cells

1992 • 30 citations

Thrombin Ca2+-dependently stimulates protein tyrosine phosphorylation in BC3H1 muscle cells

1993 • 28 citations

Activation of a phosphatidylcholine-specific phospholipase C by colony stimulating factor 1 receptor requires tyrosine phosphorylation and a guanine nucleotide-binding protein.

1991 • 26 citations

ADP-ribosylation factors, 20,000 Mr guanine nucleotide-binding protein activators of cholera toxin and components of intracellular vesicular transport systems

1993 • 26 citations

IFN-gamma potentiates the accumulation of diacylglycerol in murine macrophages.

1990 • 25 citations

Stimulatory Effects of a Short Chain Phosphatidate on Superoxide Anion Production in Guinea Pig Polymorphonuclear Leukocytes1

1989 • 24 citations

Phospholipase D activity of human amnion cells stimulated with phorbol ester and bradykinin

1993 • 23 citations

Bis(monoacylglycero) phosphate from PC12 cells, a phospholipid that can comigrate with phosphatidic acid: molecular species analysis by fast atom bombardment mass spectrometry

1992 • 21 citations

Chemotactic peptide stimulation of arachidonic acid release in HL60 cells, an interaction between G protein and phospholipase C mediated signal transduction

1991 • 21 citations

Calcium-activated phosphatidylcholine-specific phospholipase C and D in MDCK epithelial cells

1992 • 21 citations

Possible involvement of different GTP-binding proteins in noradrenaline- and thrombin-stimulated release of arachidonic acid in rabbit platelets

1990 • 20 citations

Identification and Partial Characterization of Phospholipase D in the Human Amniotic Membrane

1993 • 19 citations

Phosphatidylcholine and phosphatidylinositol‐specific phospholipases C of bull and rabbit spermatozoa

1992 • 16 citations

v-Src Induces elevated levels of diglyceride by stimulation of phosphatidylcholine hydrolysis

1992 • 14 citations

Activation of phosphorylase kinase through autophosphorylation by membrane component phospholipids

1986 • 11 citations

Deposition of cyclopropenoids in the tissue lipids of rainbow trout fed methyl sterculate

1971 • 10 citations

Activation of phospholipase D following perturbation of the human T lymphocyte antigen receptor/CD3 complex is dependent upon protein kinase C

1993 • 9 citations

Effects of phosphatidic acid on islet cell phosphoinositide hydrolysis, Ca2+, and adenylate cyclase

1989 • 9 citations

Inositol lipids and phosphatidic acid inhibit cell-free activation of neutrophil NADPH oxidase

1989 • 7 citations

Eicosanoids as essential mediators of tissue repair, defence and tumor development in skin

1993 • 1 citations