Histamine-stimulated and GTP-binding proteins-mediated phospholipase A2 activation in rabbit platelets.

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Definition and Antagonism of Histamine H2-receptors

1972 • 2,284 citations

Roles of G protein subunits in transmembrane signalling

1988 • 794 citations

An ultrasensitive method for the simultaneous determination of cyclic AMP and cyclic GMP in small-volume samples from blood and tissue

1977 • 679 citations

Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets

1983 • 589 citations

Islet-activating protein, pertussis toxin: a probe for functions of the inhibitory guanine nucleotide regulatory component of adenylate cyclase

1984 • 567 citations

Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta gamma subunits of transducin and its inhibition by the alpha subunit.

1987 • 344 citations

Two guanine nucleotide-binding proteins in rat brain serving as the specific substrate of islet-activating protein, pertussis toxin. Interaction of the alpha-subunits with beta gamma-subunits in development of their biological activities.

1986 • 315 citations

Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release in 3T3 fibroblasts. Selective susceptibility to islet-activating protein, pertussis toxin.

1985 • 245 citations

Autoregulation of histamine release in brain by presynaptic H3-receptors

1985 • 245 citations

1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis.

1985 • 222 citations

Phosphatidic acid may stimulate membrane receptors mediating adenylate cyclase inhibition and phospholipid breakdown in 3T3 fibroblasts.

1987 • 219 citations

Epidermal growth factor stimulates the rapid accumulation of inositol (1,4,5)-trisphosphate and a rise in cytosolic calcium mobilized from intracellular stores in A431 cells.

1987 • 202 citations

Differential effects of phorbol ester on phenylephrine and vasopressin-induced Ca2+ mobilization in isolated hepatocytes.

1985 • 199 citations

Phorbol myristate acetate inhibits thrombin-stimulated Ca2+ mobilization and phosphatidylinositol 4,5-bisphosphate hydrolysis in human platelets.

1985 • 179 citations

Excitatory amino acids inhibit stimulation of phosphatidylinositol metabolism by aminergic agonists in hippocampus

1986 • 162 citations

Inhibitors of Na+/H+ exchange block stimulus-provoked arachidonic acid release in human platelets. Selective effects on platelet activation by epinephrine, ADP, and lower concentrations of thrombin.

1985 • 144 citations

Cellular ADP-ribosyltransferase with the same mechanism of action as diphtheria toxin and Pseudomonas toxin A.

1984 • 128 citations

Ca2+-mobilizing actions of platelet-derived growth factor differ from those of bombesin and vasopressin in Swiss 3T3 mouse cells.

1987 • 126 citations

Histamine is an Intracellular Messenger Mediating Platelet Aggregation

1989 • 108 citations

Phorbol esters inhibit alpha 1-adrenergic effects and decrease the affinity of liver cell alpha 1-adrenergic receptors for (-)-epinephrine.

1986 • 105 citations

Possible involvement of a GTP-binding protein, the substrate of islet-activating protein, in receptor-mediated signaling responsible for cell proliferation.

1987 • 85 citations

Accumulation of inositol phosphates and cyclic AMP in guinea-pig cerebral cortical preparations

1985 • 83 citations

Metabolic and functional consequences of introducing inositol 1,4,5-trisphosphate into saponin-permeabilized human platelets

1986 • 79 citations

Epidermal growth factor receptor synthesis is stimulated by phorbol ester and epidermal growth factor. Evidence for a common mechanism.

1987 • 76 citations

Three classes of histamine receptors in brain

1986 • 71 citations

Synergistic stimulation of thromboxane biosynthesis by calcium ionophore and phorbol ester or thrombin in human platelets

1985 • 70 citations

Regulation of transferrin receptor cycling by protein kinase C is independent of receptor phosphorylation at serine 24 in Swiss 3T3 fibroblasts.

1987 • 66 citations

Inositol 1,4,5-trisphosphate induces aggregation and release of 5-hydroxytryptamine from saponin-permeabilized human platelets.

1986 • 59 citations

Phorbol ester stimulates calcium sequestration in saponized human platelets.

1987 • 59 citations

Differential sensitivity of arachidonic acid release and 1,2-diacylglycerol formation to pertussis toxin, GDP βS and NaF in saponin-permeabilized human platelets: possible evidence for distinct GTP-binding proteins involving phospholipase C and A2 activation

1987 • 58 citations

Stimulations of arachidonate release and inositol-1,4,5-triphosphate formation are mediated by distinct G-proteins in human platelets

1987 • 52 citations

Guanine Nucleotides Stimulate Arachidonic Acid Release by Phospholipase A2 in Saponin-Permeabilized Human Platelets1

1987 • 49 citations

Thrombin and C-kinase activators potentiate calcium-stimulated arachidonic acid release in human platelets

1987 • 45 citations

Phorbol ester or diacylglycerol modulates somatostatin binding to its receptors on rat pancreatic acinar cell membranes.

1986 • 41 citations

Decrease of Clonidine Binding Affinity to α₂‐Adrenoceptor by ADP‐Ribosylation of 41,000‐Dalton Proteins in Rat Cerebral Cortical Membranes by Islet‐Activating Protein

1985 • 40 citations

Pertussis toxin-sensitive GTP-binding proteins may regulate phospholipase A2 in response to thrombin in rabbit platelets

1989 • 37 citations

Enhancement of adenosine A2 and prostaglandin E1 receptor-mediated cAMP generation by prior exposure of Swiss 3T3 fibroblasts to Ca2+-mobilizing receptor agonists or phorbol ester

1989 • 23 citations

Ontogenesis of α₂‐Adrenoceptor Coupling with GTP‐Binding Proteins in the Rat Telencephalon

1989 • 23 citations

Histamine H₂ Receptor‐Mediated Cyclic AMP Formation in Human Platelets

1980 • 12 citations

Biochemical and pharmacological characterization of histamine-mediated up-regulation of human platelet serotonin uptake. Evidence for a subclass of histamine H2 receptors (H2h) highly sensitive to H2 receptor antagonists

1986 • 12 citations

Modes of inhibitory action of 4β-phorbol 12-myristate 13-acetate in thrombin-stimulated arachidonic acid release in intact and permeabilized platelets

1990 • 10 citations

Possible Regulatory Role of Histamine in Human Platelet Function Examined by Thrombin‐induced Serotonin Release

1982 • 8 citations