Identification of phosphatidylcholine-selective and phosphatidylinositol-selective phospholipases D in Madin-Darby canine kidney cells.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanol

1964 • 5,892 citations

AN ELECTRON-TRANSPORT SYSTEM ASSOCIATED WITH THE OUTER MEMBRANE OF LIVER MITOCHONDRIA

1967 • 2,311 citations

An Improved Diphenylamine Method for the Estimation of Deoxyribonucleic Acid

1965 • 1,968 citations

Quantitative analysis of phospholipids by thin-layer chromatography

1964 • 1,414 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers.

1986 • 831 citations

RECEPTORS AND PHOSPHOINOSITIDE-GENERATED SECOND MESSENGERS

1985 • 722 citations

Lipid activation of protein kinase C.

1991 • 566 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.

1987 • 472 citations

A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine.

1986 • 267 citations

A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma.

1988 • 261 citations

Regulation of Phospholipase D in HL-60 Granulocytes

1989 • 250 citations

A Glycan-Phosphatidylinositol-Specific Phospholipase D in Human Serum

1987 • 248 citations

Choline-linked Phosphoglycerides

1989 • 234 citations

1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis.

1985 • 222 citations

Phosphatidic acid may stimulate membrane receptors mediating adenylate cyclase inhibition and phospholipid breakdown in 3T3 fibroblasts.

1987 • 219 citations

Phorbol myristate acetate inhibits thrombin-stimulated Ca2+ mobilization and phosphatidylinositol 4,5-bisphosphate hydrolysis in human platelets.

1985 • 179 citations

Phorbol ester and neomycin dissociate bradykinin receptor-mediated arachidonic acid release and polyphosphoinositide hydrolysis in Madin-Darby canine kidney cells. Evidence that bradykinin mediates noninterdependent activation of phospholipases A2 and C.

1988 • 167 citations

Receptor regulation of choline phospholipid hydrolysis

1989 • 167 citations

Ca2+-dependent conversion of phosphatidylinositol to phosphatidate in neutrophils stimulated with fMet-Leu-Phe or ionophore A23187

1984 • 152 citations

Phosphatidylethanol Biosynthesis in Ethanol-exposed NG108-15 Neuroblastoma X Glioma Hybrid Cells

1989 • 151 citations

Partial purification and properties of a rat brain phospholipase.

1979 • 149 citations

Formation of diacylglycerol by a phospholipase D-phosphatidate phosphatase pathway specific for phosphatidylcholine in endothelial cells

1988 • 149 citations

Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver

1991 • 142 citations

Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5'-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol.

1991 • 134 citations

Phosphatidic acid modulates DNA synthesis, phospholipase C, and platelet-derived growth factor mRNAs in cultured mesangial cells. Role of protein kinase C.

1990 • 134 citations

Existence of cytosolic phospholipase D. Identification and comparison with membrane-bound enzyme

1991 • 120 citations

Phorbol diesters stimulate the accumulation of phosphatidate, phosphatidylethanol, and diacylglycerol in three cell types. Evidence for the indirect formation of phosphatidylcholine-derived diacylglycerol by a phospholipase D pathway and direct formation of diacylglycerol by a phospholipase C pathway.

1990 • 113 citations

Bradykinin Stimulates Phosphoinositide Hydrolysis and Mobilization of Arachidonic Acid in Dorsal Root Ganglion Neurons

1989 • 107 citations

Phosphatidylethanol formation in human platelets: Evidence for thrombin-induced activation of phospholipase D

1988 • 88 citations

Bradykinin-induced generation of inositol 1,4,5-trisphosphate in fibroblasts and neuroblastoma cells: Effect of pertussis toxin, extracellular calcium, and down-regulation of protein kinase C

1988 • 80 citations

Vasopressin, phorbol diesters and serum elicit choline glycerophospholipid hydrolysis and diacylglycerol formation in nontransformed cells: transformed derivatives do not respond

1988 • 69 citations

Synthesis of phosphatidylethanol--a potential marker for adult males at risk for alcoholism.

1988 • 65 citations

Stimulation of Phospholipase D Activity by Phorbol Esters in Cultured Astrocytes

1990 • 63 citations

Phospholipase D activity in subcellular membranes of rat ventricular myocardium

1991 • 59 citations

Phosphatidylinositol-specific phospholipase D: A pathway for generation of a second messenger

1988 • 58 citations

Biochemical characterization of phospholipase D activity from human neutrophils

1989 • 55 citations

Inositol is the water-soluble product of acetylcholine-stimulated breakdown of phosphatidylinositol in mouse pancreas

1975 • 53 citations

Bradykinin stimulates phosphodiesteratic cleavage of phosphatidylcholine in cultured endothelial cells

1988 • 52 citations

Vasopressin-induced polyphosphoinositide and phosphatidylcholine degradation in fibroblasts. Temporal relationship for formation of phospholipase C and phospholipase D hydrolysis products.

1990 • 51 citations

12-O-Tetradecanoylphorbol-13-acetate activates the synthesis of phosphatidylethanol in animal cells exposed to ethanol

1987 • 50 citations

Bradykinin Activates a Phospholipase D that Hydrolyzes Phosphatidylcholine in PC12 Cells

1991 • 39 citations

Bradykinin-induced changes in Inositol trisphosphate mass in MDCK cells

1986 • 37 citations

Activation and solubilization by triton X‐100 of membrane‐bound phospholipase D of rat brain

1991 • 36 citations

Guanine Nucleotide‐Binding Protein Regulation of Microsomal Phospholipase D Activity of Canine Cerebral Cortex

1990 • 33 citations

Phorbol esters stimulate a phospholipase D‐catalysed reaction with both ester‐ and ether‐linked phospholipids in HeLa cells

1989 • 27 citations

Bradykinin-induced changes in phosphoinositides, inositol phosphate production and intracellular free calcium in cultured bovine aortic endothelial cells

1989 • 23 citations

Membrane‐Associated Phospholipase D Activity in Rat Sciatic Nerve

1991 • 18 citations