Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5'-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.

1987 • 472 citations

Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils

1989 • 429 citations

Rapid formation of diacylglycerol from phosphatidylcholine: a pathway for generation of a second messenger.

1986 • 415 citations

Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes.

1988 • 307 citations

1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. A common source of platelet-activating factor and arachidonate in human polymorphonuclear leukocytes.

1984 • 296 citations

A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine.

1986 • 267 citations

Regulation of Phospholipase D in HL-60 Granulocytes

1989 • 250 citations

Choline-linked Phosphoglycerides

1989 • 234 citations

Activation of human neutrophil phospholipase D by three separable mechanisms

1990 • 220 citations

Phospholipase D

1978 • 190 citations

1-O-alkyl-linked glycerophospholipids of human neutrophils: distribution of arachidonate and other acyl residues in the ether-linked and diacyl species.

1984 • 173 citations

Phospholipase D in cell signalling and its relationship to phospholipase C

1991 • 172 citations

The phosphatidylcholine pathway of diacylglycerol formation stimulated by phorbol diesters occurs via phospholipase D activation

1988 • 156 citations

Ca2+-dependent conversion of phosphatidylinositol to phosphatidate in neutrophils stimulated with fMet-Leu-Phe or ionophore A23187

1984 • 152 citations

Partial purification and properties of a rat brain phospholipase.

1979 • 149 citations

Isolation of human eosinophil phospholipase D.

1976 • 139 citations

Stimulation of Phosphatidylcholine Hydrolysis, Diacylglycerol Release, and Arachidonic Acid Production by Oncogenic Ras Is a Consequence of Protein Kinase C Activation

1989 • 136 citations

Multiple forms of myeloperoxidase from human neutrophilic granulocytes: Evidence for differences in compartmentalization, enzymatic activity, and subunit structure

1983 • 134 citations

Ca^{2 +}‐mobilizing hormones elicit phosphatidylethanol accumulation via phospholipase D activation

1987 • 130 citations

Hormonal stimulation of diacylglycerol formation in hepatocytes.

1989 • 111 citations

Phorbol myristate acetate (PMA) augments chemoattractant-induced diglyceride generation in human neutrophils but inhibits phosphoinositide hydrolysis. Implications for the mechanism of PMA priming of the respiratory burst.

1988 • 101 citations

A neutral phospholipase D activity from rat brain synaptic plasma membranes. Identification and partial characterization.

1990 • 100 citations

Muscarinic acetylcholine receptor regulates phosphatidylcholine phospholipase D in canine brain

1989 • 96 citations

Phospholipase D in homogenates from HL-60 granulocytes: Implications of calcium and G protein control

1989 • 91 citations

Phorbol ester treatment of intact rabbit platelets greatly enhances both the basal and guanosine 5′-[γ-thio]triphosphate-stimulated phospholipase D activities of isolated platelet membranes. Physiological activation of phospholipase D may be secondary to activation of phospholipase C

1990 • 90 citations

Elevated cytosolic Ca2+ activates phospholipase D in human platelets

1991 • 90 citations

THE PHOSPHORUS-CONTAINING LIPIDES OF THE CARROT

1947 • 89 citations

Breakdown and synthesis of polyphosphoinositides in fMetLeuPhe‐stimulated neutrophils

1985 • 88 citations

Overexpression of protein kinase C beta 1 enhances phospholipase D activity and diacylglycerol formation in phorbol ester-stimulated rat fibroblasts.

1991 • 87 citations

Activation of the respiratory burst oxidase in neutrophils: On the role of membrane-derived second messengers, Ca++, and protein kinase C

1988 • 83 citations

Microsomal phospholipase D of rat brain and lung tissues

1980 • 81 citations

Phorbol diesters and dioctanoylglycerol stimulate accumulation of both diacylglycerols and alkylacylglycerols in human neutrophils.

1988 • 79 citations

12-O-tetradecanoylphorbol-13-acetate activates phosphatidylethanol and phosphatidylglycerol synthesis by phospholipase D in cell lysates

1988 • 78 citations

Differential activation by fMet‐Leu‐Phe and phorbol ester of a plasma membrane phosphatidylcholine‐specific phospholipase D in human neutrophil

1989 • 63 citations

Granulocyte phospholipase D is activated by a guanine nucleotide dependent protein factor

1991 • 62 citations

Dynamics of the Diradylglycerol Responses of Stimulated Phagocytes

1989 • 59 citations

On the Biological Occurrence and Regulation of 1-Acyl and 1-O-Alkyl-diradylglycerols in Human Neutrophils

1989 • 59 citations

Biochemical characterization of phospholipase D activity from human neutrophils

1989 • 55 citations

Inositol is the water-soluble product of acetylcholine-stimulated breakdown of phosphatidylinositol in mouse pancreas

1975 • 53 citations

Phorbol-12-myristate-13-acetate activation of phospholipase D in human neutrophils leads to the production of phosphatides and diglycerides

1990 • 48 citations

Evidence for protein kinase C independent activation of phospholipase D by phorbol esters in lymphocytes

1990 • 47 citations

Fluoride activates diradylglycerol and Superoxide generation in human neutrophils via PLD/PA phosphohydrolase-dependent and -independent pathways

1990 • 35 citations

Ether-phospholipid composition in neutrophile and platelets

1985 • 25 citations