Modulation of phospholipase A2 activity by epidermal growth factor (EGF) in CHO cells transfected with human EGF receptor. Role of receptor cytoplasmic subdomain

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Epidermal Growth Factor and a New Derivative

1972 • 1,225 citations

Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.

1980 • 798 citations

The importance of phospholipase-A2 in prostaglandin biosynthesis

1976 • 647 citations

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

1987 • 609 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

The regulation of lipomodulin, a phospholipase inhibitory protein, in rabbit neutrophils by phosphorylation.

1981 • 424 citations

Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells.

1986 • 424 citations

Isolation of a calcium-dependent 35-kilodalton substrate for the epidermal growth factor receptor/kinase from A-431 cells.

1984 • 366 citations

Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation

1989 • 356 citations

Epidermal growth factor-dependent phosphorylation of lipocortin

1986 • 303 citations

Phospholipase A2 and phospholipase C activities of platelets. Differential substrate specificity, Ca2+ requirement, pH dependence, and cellular localization.

1980 • 287 citations

Epidermal growth factor stimulates prostaglandin production and bone resorption in cultured mouse calvaria

1978 • 271 citations

Self-phosphorylation enhances the protein-tyrosine kinase activity of the epidermal growth factor receptor.

1985 • 232 citations

Evidence of protein kinase C involvement in phorbol diester-stimulated arachidonic acid release and prostaglandin synthesis.

1987 • 232 citations

Facilitation of phospholipase A2 activity by mastoparans, a new class of mast cell degranulating peptides from wasp venom.

1983 • 224 citations

Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor.

1990 • 188 citations

Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization.

1988 • 186 citations

Activation of high levels of endogenous phospholipase A2 in cultured cells.

1979 • 174 citations

Activation of alpha 1-adrenoceptors, protein kinase C, or treatment with intracellular free Ca2+ elevating agents increases pineal phospholipase A2 activity. Evidence that protein kinase C may participate in Ca2+-dependent alpha 1-adrenergic stimulation of pineal phospholipase A2 activity.

1987 • 140 citations

Epidermal growth factor stimulation of prostaglandin E2 biosynthesis in amnion cells. Induction of prostaglandin H2 synthase.

1988 • 135 citations

Epidermal growth factor stimulates prostaglandin biosynthesis by canine kidney (MDCK) cells

1977 • 133 citations

Regulation of epidermal growth factor-stimulated formation of inositol phosphates in A-431 cells by calcium and protein kinase C.

1988 • 131 citations

Mitogenic signaling by epidermal growth factor (EGF), but not platelet-derived growth factor, requires arachidonic acid metabolism in BALB/c 3T3 cells. Modulation of EGF-dependent c-myc expression by prostaglandins.

1990 • 130 citations

Epidermal growth factor enhances glomerular mesangial cell soluble phospholipase A2 activity.

1990 • 130 citations

Alpha 1-adrenergic receptor-mediated phosphoinositide hydrolysis and prostaglandin E2 formation in Madin-Darby canine kidney cells. Possible parallel activation of phospholipase C and phospholipase A2.

1987 • 120 citations

Alteration of epidermal growth factor receptor activity by mutation of its primary carboxyl-terminal site of tyrosine self-phosphorylation.

1988 • 120 citations

Role of arachidonic acid metabolism in the mitogenic response of BALB/c 3T3 fibroblasts to epidermal growth factor.

1988 • 117 citations

Calcium dependency of prostaglandin E2 production in rat glomerular mesangial cells. Evidence that protein kinase C modulates the Ca2+-dependent activation of phospholipase A2.

1988 • 103 citations

Bradykinin-induced Activation of Phospholipase A2 Is Independent of the Activation of Polyphosphoinositide-hydrolyzing Phospholipase C

1989 • 86 citations

Phosphatidylcholine biosynthesis in cultured glioma cells: evidence for channeling of intermediates

1989 • 80 citations

Ca2+.Calmodulin-dependent release of arachidonic acid for renal medullary prostaglandin synthesis. Evidence for involvement of phospholipases A2 and C.

1983 • 77 citations

Epidermal growth factor is synergistic with phorbol esters and vasopressin in stimulating arachidonate release and prostaglandin production in renal glomerular mesangial cells

1988 • 71 citations

Synergistic release of arachidonic acid from platelets by activators of protein kinase C and calcium ionophores. Evidence for the role of protein phosphorylation in the activation of phospholipase A2 and independence from the sodium/hydrogen ion exchanger

1989 • 71 citations

Effect of 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) on the growth inhibitory and increased phosphatidylinositol (PI) responses induced by epidermal growth factor (EGF) in A431 cells

1983 • 71 citations

Diacylglycerol stimulates phospholipase A₂ from Swiss 3T3 fibroblasts

1988 • 57 citations

Stimulation of arachidonic acid release by guanine nucleotide in saponin-permeabilized neutrophils: Evidence for involvement of GTP-binding protein in phospholipase A2 activation

1988 • 56 citations

Effects of DNA and prostaglandin synthesis inhibitors on the stimulation of bone resorption by epidermal growth factor in fetal rat long-bone cultures.

1986 • 52 citations

Transforming growth factor beta modulates epidermal growth factor-induced phosphoinositide metabolism and intracellular calcium levels.

1988 • 49 citations

Phosphatidylcholine metabolism in cultured cells: catabolism via glycerophosphocholine

1988 • 47 citations

Lysophosphatidylcholine as an intermediate in phosphatidylcholine metabolism and glycerophosphocholine synthesis in cultured cells: an evaluation of the roles of 1-acyl- and 2-acyl-lysophosphatidylcholine

1989 • 44 citations

Translocation of phospholipase A2 from cytosol to membranes induced by 1-oleoyl-2-acetyl-glycerol in serum-free cultured macrophages

1987 • 42 citations

Tyrosine Kinase Activity Is Essential for the Association of Phospholipase C-γ with the Epidermal Growth Factor Receptor

1990 • 41 citations

Epidermal growth factor stimulates phospholipase A2 in vasopressin-treated rat glomerular mesangial cells

1988 • 41 citations

Alterations in distribution of cardiac output in experimental diabetes in rats

1989 • 39 citations

A phospholipase D-like mechanism in pancreatic islet cells: Stimulation by calcium ionophore, phorbol ester and sodium fluoride

1989 • 36 citations

No direct correlation between Ca2+ mobilization and dissociation of Gi during platelet phospholipase A2 activation

1988 • 30 citations

Epidermal Growth Factor Stimulates Release of Arachidonic Acid in Pig Epidermis

1985 • 28 citations

Loss of three major auto phosphorylation sites in the EGF receptor does not block the mitogenic action of EGF

1988 • 25 citations

Epidermal-growth-factor-stimulated phosphorylation of calpactin II in membrane vesicles shed from cultured A-431 cells

1989 • 20 citations

Calcium-dependent binding of calmodulin to phospholipase A2 subunits induces enzymatic activation

1985 • 17 citations

Specific receptors for epidermal growth factor in human bone tumour cells and its effect on synthesis of prostaglandin E2 by cultured osteosarcoma cell line

1984 • 15 citations