Synergistic activation of type III protein kinase C by cis-fatty acid and diacylglycerol

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Ultrasensitive Stain for Proteins in Polyacrylamide Gels Shows Regional Variation in Cerebrospinal Fluid Proteins

1981 • 2,972 citations

Fluorometric assay of proteins in the nanogram range

1973 • 1,640 citations

Turnover of Inositol Phospholipids and Signal Transduction

1984 • 1,629 citations

Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers.

1986 • 831 citations

Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C

1990 • 829 citations

The structure, expression, and properties of additional members of the protein kinase C family.

1988 • 706 citations

Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence.

1989 • 439 citations

Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells.

1986 • 424 citations

The mechanism of protein kinase C activation

1989 • 423 citations

Isozymic forms of rat brain Ca2+-activated and phospholipid-dependent protein kinase.

1986 • 389 citations

The Family of Protein Kinase C for Signal Transduction

1989 • 383 citations

Expression and Properties of Two Types of Protein Kinase C: Alternative Splicing from a Single Gene

1987 • 317 citations

Synergistic action of diacylglycerol and unsaturated fatty acid for protein kinase C activation: its possible implications.

1991 • 316 citations

Protein kinase C activation by cis-fatty acid in the absence of Ca2+ and phospholipids.

1986 • 309 citations

Competitive inhibition by diacylglycerol of specific phorbol ester binding.

1984 • 306 citations

Direct activation of purified protein kinase C by unsaturated fatty acids (oleate and arachidonate) in the absence of phospholipids and Ca²⁺

1985 • 293 citations

Three distinct forms of rat brain protein kinase C: Differential response to unsaturated fatty acids

1987 • 239 citations

Distinct patterns of expression of different protein kinase C mRNAs in rat tissues

1987 • 227 citations

Mode of Activation and Kinetic Properties of Three Distinct Forms of Protein Kinase C from Rat Brain1

1988 • 225 citations

Identification of the structures of multiple subspecies of protein kinase C expressed in rat brain

1987 • 202 citations

Selective activation of the γ‐subspecies of protein kinase C from bovine cerebellum by arachidonic acid and its lipoxygenase metabolites

1989 • 188 citations

Preparation of metal-chelate complexes and the design of steady-state kinetic experiments involving metal nucleotide complexes.

1979 • 175 citations

Purification and characterization of three types of protein kinase C from rabbit brain cytosol.

1987 • 168 citations

Immunocytochemical localization of beta II subspecies of protein kinase C in rat brain.

1989 • 159 citations

Calcium-Independent Activation of Hypothalamic Type I Protein Kinase C by Unsaturated Fatty Acids

1988 • 120 citations

Electron microscopic localization of type I protein kinase C in rat Purkinje cells

1988 • 118 citations

Regulation of platelet protein kinase C by oleic acid. Kinetic analysis of allosteric regulation and effects on autophosphorylation, phorbol ester binding, and susceptibility to inhibition.

1990 • 116 citations

The Albert Lasker Medical Awards. The family of protein kinase C for signal transduction

1989 • 111 citations

Fatty acid stimulation of membrane phosphatidylinositol hydrolysis by brain phosphatidylinositol phosphodiesterase

1979 • 110 citations

Distinct cellular and regional localization of immunoreactive protein kinase C in rat brain.

1987 • 98 citations

Activation of protein kinase C by cis- and trans-fatty acids and its potentiation by diacylglycerol

1988 • 90 citations

Activation signals in human lymphocytes. Incorporation of polyunsaturated fatty acids into plasma membrane phospholipids regulates IL-2 synthesis via sustained activation of protein kinase C.

1989 • 79 citations

Immunocytochemical localization of the beta I subspecies of protein kinase C in rat brain.

1989 • 72 citations

Immunocytochemical localization of the alpha subspecies of protein kinase C in rat brain.

1990 • 67 citations

Phorbol esters and diacylglycerols amplify bradykinin-stimulated prostaglandin synthesis in Swiss 3T3 fibroblasts. Possible independence from protein kinase C.

1988 • 57 citations

Diacylglycerol stimulates phospholipase A₂ from Swiss 3T3 fibroblasts

1988 • 57 citations

Protein kinase C subspecies in adult rat hippocampal synaptosomes Activation by diacylglycerol and arachidonic acid

1991 • 56 citations

Properties of protein kinase c subspecies in human platelets

1988 • 54 citations

Stimulation of mitogenesis and glucose transport by 1-monooleoylglycerol in Swiss 3T3 fibroblasts.

1988 • 52 citations

Kinetic evidence that 1,2-diolein inhibits phorbol ester binding to protein kinase C via a competitive mechanism

1985 • 48 citations

Determination of free Ca ion concentrations with an ion-selective electrode in the presence of chelating agents in comparison with calculated values

1978 • 42 citations

Fatty acid activation of protein kinase C: Dependence on diacylglycerol

1988 • 39 citations

Activation of protein kinase C by cis- and trans-octadecadienoic acids in intact human platelets and its potentiation by diacylglycerol

1987 • 38 citations

Expression of protein kinase C subspecies in human leukemia‐ lymphoma cell lines

1989 • 31 citations

Localization of isoenzymes II/III of protein kinase C in the rat visual cortex (area 17), hippocampus and dentate gyrus

1988 • 30 citations

Linoleic acid is a potent activator of protein kinase C type III- α isoform in pancreatic acinar cells; its role in amylase secretion

1988 • 29 citations

Membrane surface pressure can account for differential activities of membrane-penetrating molecules.

1988 • 26 citations