Activation of neutrophil leukocytes: chemoattractant receptors and respiratory burst ¹

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

1989 • 2,518 citations

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

Structure and Functional Expression of a Human Interleukin-8 Receptor

1991 • 1,088 citations

Calyculin A and okadaic acid: Inhibitors of protein phosphatase activity

1989 • 1,032 citations

Cloning of Complementary DNA Encoding a Functional Human Interleukin-8 Receptor

1991 • 878 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins).

1988 • 674 citations

The chemotactic receptor for human C5a anaphylatoxin

1991 • 660 citations

The superoxide‐generating oxidase of phagocytic cells

1991 • 564 citations

Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration

1986 • 489 citations

An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues

1989 • 482 citations

Enzymic mechanisms of superoxide production

1991 • 475 citations

Structure-activity relationships of interleukin-8 determined using chemically synthesized analogs. Critical role of NH2-terminal residues and evidence for uncoupling of neutrophil chemotaxis, exocytosis, and receptor binding activities.

1991 • 425 citations

Two adjacent cysteine residues in the C‐terminal cytoplasmic fragment of bovine rhodopsin are palmitylated

1988 • 409 citations

Rhodopsin Mutants That Bind But Fail to Activate Transducin

1990 • 377 citations

Amino-terminal leucine-rich repeats in gonadotropin receptors determine hormone selectivity.

1991 • 330 citations

The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors

1990 • 323 citations

Assembly of functional rhodopsin requires a disulfide bond between cysteine residues 110 and 187.

1990 • 320 citations

Activation of human neutrophil nicotinamide adenine dinucleotide phosphate, reduced (triphosphopyridine nucleotide, reduced) oxidase by arachidonic acid in a cell-free system.

1985 • 315 citations

Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase.

1989 • 310 citations

Molecular cloning and expression of platelet-activating factor receptor from human leukocytes.

1991 • 300 citations

Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA

1990 • 254 citations

Phosphorylation of neutrophil 47-kDa cytosolic oxidase factor. Translocation to membrane is associated with distinct phosphorylation events.

1990 • 248 citations

Association of a Ras-related protein with cytochrome b of human neutrophils

1989 • 248 citations

Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils. Reversibility by albumin.

1984 • 230 citations

Role of acidic amino acids in peptide substrates of the .beta.-adrenergic receptor kinase and rhodopsin kinase

1991 • 220 citations

The role of cytokines in the pathogenesis of inflammatory eye disease

1992 • 218 citations

Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells

1991 • 218 citations

Role of extracellular disulfide-bonded cysteines in the ligand binding function of the .beta.2-adrenergic receptor

1990 • 215 citations

Relationship of protein phosphorylation to the activation of the respiratory burst in human neutrophils. Defects in the phosphorylation of a group of closely related 48-kDa proteins in two forms of chronic granulomatous disease.

1988 • 181 citations

Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effects on activation of NADPH oxidase.

1991 • 165 citations

Regulation of the superoxide-generating NADPH oxidase by a small GTP-binding protein and its stimulatory and inhibitory GDP/GTP exchange proteins.

1992 • 159 citations

Receptor class desensitization of leukocyte chemoattractant receptors.

1991 • 146 citations

Role of the intradiscal domain in rhodopsin assembly and function.

1990 • 139 citations

Activation of NADPH-dependent superoxide production in plasma membrane extracts of pig neutrophils by phosphatidic acid.

1988 • 138 citations

The onset of the respiratory burst in human neutrophils. Real-time studies of H2O2 formation reveal a rapid agonist-induced transduction process.

1987 • 117 citations

Staurosporine inhibits the respiratory burst and induces exocytosis in human neutrophils

1989 • 98 citations

Isoprenoid metabolism is required for stimulation of the respiratory burst oxidase of HL-60 cells.

1992 • 89 citations

Vanadate and molybdate increase tyrosine phosphorylation in a 50-kilodalton protein and stimulate secretion in electropermeabilized platelets

1989 • 79 citations

The interleukin-8 receptor is encoded by a neutrophil-specific cDNA clone, F3R

1991 • 79 citations

Agonist-promoted sequestration of the beta 2-adrenergic receptor requires regions involved in functional coupling with Gs.

1989 • 75 citations

Resolution of a low molecular weight G protein in neutrophil cytosol required for NADPH oxidase activation and reconstitution by recombinant Krev-1 protein

1991 • 73 citations

Diradylglycerol synergizes with an anionic amphiphile to activate superoxide generation and phosphorylation of p47phox in a cell-free system from human neutrophils.

1990 • 67 citations

Effects of antagonists of protein phosphatases on superoxide release by neutrophils.

1992 • 67 citations

Continuous phosphorylation of both the 47 and the 49 kDa proteins occurs during superoxide production by neutrophils

1990 • 66 citations

Modulation of neutrophil activation by okadaic acid, a protein phosphatase inhibitor

1992 • 61 citations

The activity of one soluble component of the cell-free NADPH:O2 oxidoreductase of human neutrophils depends on guanosine 5'-O-(3-thio)triphosphate.

1990 • 60 citations

Synergistic stimulation of neutrophils. Possible involvement of 5-hydroxy-6,8,11,14-eicosatetraenoate in superoxide release.

1988 • 57 citations

Mass determination of receptor-mediated accumulation of phosphatidate and diglycerides in human neutrophils measured by coomassie blue staining and densitometry

1989 • 56 citations

Functional expression of the human formyl peptide receptor in Xenopus oocytes requires a complementary human factor

1991 • 54 citations

Transmembrane signalling by the N-formyl peptide receptor in stably transfected fibroblasts

1991 • 48 citations

Nucleoside triphosphate requirements for superoxide generation and phosphorylation in a cell-free system from human neutrophils. Sodium dodecyl sulfate and diacylglycerol activate independently of protein kinase C.

1991 • 47 citations

Molecular basis of the autosomal recessive forms of chronic granulomatous disease.

1992 • 46 citations

Seven-helix receptors

1991 • 39 citations

Phosphorylation of both 47 and 49kDa proteins accompanies superoxide release by neutrophils

1989 • 34 citations

Neutrophil Activation: Control of Shape Change, Exocytosis, and Respiratory Burst

1992 • 21 citations

Functional expression of a human C5a receptor clone in Xenopus oocytes requires additional RNA

1991 • 15 citations